I was initially put on the 250 and thought it was wonderful because I could breathe again ! After about 4 months though I began to have episodes of my knees and ankles collapsing with no notice. I was hurting in all of my joints and went through a whole series of tests for rheumatoid arthritis which came out negative. My doctor reduced the Advair to 100 since I was breathing so well and these problems with my joints got somewhat better. I did not put it together with the reduction in Advair dosage. THen about 6 months later, my asthma became worse and he upped me to the 250 again. Well, I can breathe but I am unable to walk very well. My knees, ankles, elbows and shoulders all ache constantly. I am afraid of falling as my knees and ankles give out several times a day. It is really frightening. I have told my doctor that I think there is a connection, but he dismisses my theory. I think he thinks I am a hypochondriac !!! I am upset because I really think there is a connection and I know this was a new drug and now I am worried that if I get off of it my ashtma will be worse than before.