After three doses of omeprazole, my blood pressure went to 220/110 and I developed an itching all over my body. Emergency room personnel treated the episode as an allergic reaction, gave me an antihypertensive and Zyrtec; and my blood pressure returned to normal. Bloodwork and EKG were normal. My insurer had me switched from Aciphex (prescribed for gastro-esophogeal reflux disease) to the generic omeprazole; I am appealing since others and I have had such a bad experience with omeprazole. Physicians should prescribe omeprazole with great care; in my experience, it sucks.