I have been taking Lopressor for 25 YEARS! Yes as with all drugs there are side effects, but this drug is VERY safe and long term use is VERY beneficial. Takes about a month for your body to adjust then you should be fine. Is in the older-class of drugs and is very safe. I take 50mg twice a day. No problems here, and its one of the less expensive drugs for high blood pressure and heart medicines around. Good luck! Im a advocate of Lopressor.