Glad to read some of the experiences of others. Now I don't feel so worried. I have never experienced such nasty side effects. I am now off the Prednisone and feel the come-down is as bad as being on the drug. Most of the time I feel numb in my muscles. A drunk feeling without the booze. While on the drug, I experienced terrible sleeping troubles, emoitional highs and lows and extreme hunger, 24/7. Today, I a very sore in my neck and shoulder region. The shaking and tweeking were bad too. As well as the disconnected feeling of not being able to complete sentences or thoughts. I feel as if i have been losing my mind. One bit of advise, I wouldn't work out extrememly hard while on Prednisone. Walking is fine but anything highly aerobic, like kick boxing or jogging feels like you're in cardiac arrest.