I am in so much pain....i have to have a knee replacement but i am not yet 50 so the doctor would like to wait...right now my knee is bone on bone...i have severe osteoarthritis in my feet and both my knees...i have tried ArthroTec, Vioxx, Celebrex, Mobic and now Bextra...nothing has taken the pain off....i am tired of dealing with pain....so i will try this Ultracet...i will post any side affects if there are any...