I have been on Advair 500/50 for 2 years taking 1 puff twice daily. I have had these side effects:
weight gain
dry skin
itchy skin
pain in muscles and joints, mostly legs
thin skin on arms
bleeding problems/ clotting disorder
rapid heart beat
thinning hair
difficulty sleeping
thirsty throughout the night
dental problems
water retention
heartburn
I hate taking this drug but it does help keep my COPD(emphysema) under control. I get depressed at times due the side effects of this drug and the impact it has on my life and how I feel about myself. I often think of just stopping the drug and seeing how I feel but I am afraid to.