Obviously Lupron isn't right for everyone, but I have a positive experience with it to report. Initial (normal and expected) moodiness for approximately one week after each injection. Hot Flashes (treated with Premarin). Insomnia (again, treated with Premarin). Slight weight gain (6 pounds). Decreased libido with vaginal dryness. I've been receiving Lupron injections since Dec. 2001 (it's now Feb. 2003) to treat my severe PMS. The quality of my life has improved significantly and I'd rather deal with the few side effects from Lupron than the PMS. Unfortunately, this cannot be a continued long-term treatment and I'm currently faced with having to make a decision - total hysterectomy or ?