Started on Vytorin (Zocor 20 mg/Zetia 10mg) on 12-23-04. I had previously been on 40 mg of Pravochol with 10 mg of Zetia with little side effects. However after 6 months on Vytorin my sex drive has diminished and my left ankle swells and aches after my daily 30 minute jog (have been jogging for over 25 year without any ankle problems). 3 days ago I began splitting my Vytorin 10/20 pill and have noticed the ankle pain has subsided greatly. The ankle pain has persisted for the last 6 months while on the Vytorin. My cholesterol has plummeted to 133 (which I personally think is too low). I am planning to have my doctor put me back on a lower dose (20mg) of Pravachol and Zetia as before. Anyone esle have this problem with Vytorin?