I'm Bipolar Mixed, OCD and I've been taking 50 mg. Topamax daily for about 3 months now and I have noticed fatigue, mild depression, decreased libido, and impotence since using this drug. I also take Paxil 20 mg. and Wellbutrin 150 mg. to try and combat the impotence. I don't know if I will have to discontinue Topamax, increase Wellbutrin or add Viagra; these meds are getting expensive. The Topamax calms my mood and helps with the appetite increase from Paxil though. Also, I noticed an increase in the decrease of libido once i started Topamax in addition to Paxil's contributing impotence. Any input would be helpful.