I got my shot a few days before my wedding and it was the best gift ever. Before the shot I spent four years dragging myself around with lupus and chronic fatigue. Prednisone made me insane and miserable. I've felt like my old self again, for the first time in four years. I didn't have to sneak out of my own reception to take a nap. It's only been 6 weeks and I think it's wearing off. I wish it would never wear off. Reading these posts, it appears that as with other steroids, it is a trade-off. I'd gladly walk around with a dent, just to be walking around.