The first time I was put on zoloft I had diarrhea constantly. I would go out to eat at a restaurant and before I had even left the restaurant, the entire dinner had already passed through me - mostly undigested. I couldn't sleep, but I had tons of energy. This went on for months, and I lost 30 lbs. Along with a lot of hair. I don't remember whether or not I was as twitchy before I started taking zoloft. I've had bad dry mouth, but I've found that Biotene toothpaste and mouthwash help out with that very much. The odd thing is, I had to stop taking zoloft because I changed jobs and couldn't afford it without insurance. Now that I'm back on it, my side effects are completely different. I have major headaches, fatigue, I can sleep all day, and I can't concentrate to save my life. I haven't had any diarrhea, in fact I feel constipated, and hungry. I'm gaining weight instead of losing...?