Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Lisinopril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Lisinopril lowers blood pressure and also relieves symptoms of fluid retention.
The combination of hydrochlorothiazide and lisinopril is used to treat hypertension (high blood pressure).
Hydrochlorothiazide and lisinopril may also be used for other purposes not listed in this medication guide.
Do not use this medication if you are unable to urinate. You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), moexipril (Univasc), perindopril (Aceon), quinapril (Accupril), ramipril (Altace), or trandolapril (Mavik).
Before taking hydrochlorothiazide and lisinopril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs.
Lisinopril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and lisinopril without telling your doctor if you are pregnant or planning a pregnancy. Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and lisinopril, unless your doctor has told you to.
Some things can cause your blood pressure to get too low. This includes vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking other diuretics (water pills). Follow your doctor’s instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and lisinopril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
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