PredniSONE I'm 18 years old and I have been taking high doses of prednisone for over 3 years for a blood disorder known as hemolytic anemia. At one point I was taking 80mg a day. I am now on 30mg a day. It is unknown whether my body will ever be able to function without the steroids and chemotherapy has even been suggested by one doctor. The difficulty of having massive amounts of weight gain (30 lbs. in 3 months) during high school was virtually unbearable. In addition to that, I now have to take 2 antidepressants to counter the mood swings and depression that the prednisone causes.