Lisinopril I wanted to find out if others had the same EXTREME fatigue when taking Lisinopril. I was relieved to find that my tireness had more to do with Lisinopril than my overall health. I've noticed that when I stop taking Lisinopril my energy level returns to a high rate and I am happier and more agreeable (my normal self). With Lisinopril, I was almost like in a depression state. I have an appointment with my PCP in a week to discuss the alternatives. Thanks to everyone who has shared their story to keep us all healthy and happy.