Guaifenex Yikes!!!! I just started taking Guaifenex last night, 1/2 a pill twice a day, and was looking on the Internet about the drug when I saw this website. I don't know whether to continue or not. I was prescribed Guaifenex for severe sinus headaches that I have had for the last 3 weeks. Last night a few hours after taking it, I felt some relief. So even though a lot of the comments here are negative, I think I will give it a try for a few more day. I'll let you know if anything drastic happens.