PredniSONE Hello My husband has been taking prednisone for a while. It was until this week that I read about all the horrible side effects of this medication and I realized the reason for my husband's changes in appearance and moods. Our marriage is breaking appart. There is nothing well for him. Everybody in the world is wrong for him. Paranoia, depression, bad sleep and much more is part of our daily lives. Please, I need help.We both need help!!!! He does not accept that is the medication. What can I do??? Please!!