Effexor I have been using this drug for about 8 months and have found some of the side effects can be horrible. However i am in the process of separation and im terrified to face this without them. I know i am rather numb and at times just unconnected because of the drug but without them i would be crying constantly and i hated that. I believe i have been depressed for some time and i know for me the benefits of this drug far out way the difficulties of depression! The crying, sleeplessness, inability to get anything accomplished depression sucks. For me i have not gained or lost i am about the same. My therapist tells me to go off them slowly once things settle down i am on 300 mg of them now of which i started on 75mg to start. So i will keep you updated to my progress with getting off them!