Pramocaine (INN and BAN, also known as pramoxine) is a topical anesthetic used as an antipruritic.

The popular itch cream Gold Bond uses pramocaine hydrochloride to numb sensitive skin. The hydrochloride salt form of pramocaine is water-soluble, and therefore more easily absorbed into the skin.

Topical anesthetics are used to relieve pain and itching caused by conditions such as sunburn or other minor burns, insect bites or stings, poison ivy, poison oak, poison sumac, and minor cuts and scratches. Pramocaine and dibucaine are also common ingredients in over the counter hemorrhoid preparations.