http://www.medications.com/effect/view/15291 I have been taking Doxycycline 100mg twice a day for about 10 days now. It has for some reason effected my joints. It started in my knees and seems to be moving to other joints like my wrist. I did see other posting with the same problems, but not a lot. I Tue, 24 Jun 2008 02:46:06 -0400 http://www.medications.com/effect/view/15291?item=9458 I am having the exact same thing. I don't know if it's Lyme's or the doxy, but a week after taking the Doxy, all of my fingers swelled up in a matter of minutes and became very painful..I can't even open bottles, etc. Then my knees, wrists, shoulder, hip, http://www.medications.com/effect/view/15291?item=9458