http://www.medications.com/effect/view/18534 I was taking doxycycline for about a month and one night experienced really bad indegestion (or thats what it felt like). After that it got worse. It casued me to have such bad acid reflux that it had begun to destroy my esophogus. I couldn't eat anything w Tue, 02 Dec 2008 15:54:32 -0500 http://www.medications.com/effect/view/18534?item=14960 wow im on doxycycline and i too am having bad indegestion! it brings me to nausea,headaches as well! i see my doctor in the morning and will bring up what symptoms i have! good luck http://www.medications.com/effect/view/18534?item=14960