http://www.medications.com/effect/view/19495 I was on Prednisone for 3 weeks (3/daily, week 1; 2/daily week 2 and 1/daily, week 3 -- I forget the dosage) for some exzema on my hands. It took care of the exzema but made me very irritable and depressed. I've also had some intermittent weird rash/itc