http://www.medications.com/effect/view/20576 I started taking Levaquin 500mg 3 22 07 on the 3rd day My legs hurt so bad I could hardly walk. My knees also hurt, My hips & back of legs allthe way down my legs the muscles hurt so bad I cried,even when I walked the back of my ankles it would pull I would Tue, 08 Jul 2008 21:54:38 -0400 http://www.medications.com/effect/view/20576?item=9899 I started taking Levaquin 500 mg for a sinus infection. I was supposed to take the pills for 11 days. I experienced the same thing with severe muscle pain in my knees and joints. My legs would barely bent because they were so swollen.My first reaction was http://www.medications.com/effect/view/20576?item=9899