http://www.medications.com/effect/view/21574 I have confusion.Difficulty speaking certain words.Memory seems altered.I have been using the tablets of estradiol for almost a year My problems seem to be increasing in severity. I use this medication due to hysterectomy. I am 47 years old.I also wake up a Mon, 19 May 2008 18:09:08 -0400 http://www.medications.com/effect/view/21574?item=8430 I have had the same experience with estradiol and other similar HRT meds. I have also had a lot of swelling in my calves too. I also found out the hard way that these medications can cause gallbladder disease. I had mine removed in Dec after three years on http://www.medications.com/effect/view/21574?item=8430