http://www.medications.com/effect/view/21813 I have been taking 1g Niaspan for about 2 years for cholesterol. Here are the things that I have found that increase or decrease side effects: 1. Taking an 81mg asprin 30 min before reduces flush. 350mg doesn't do any better than 81mg. 2. Energetic ex Thu, 27 Sep 2007 19:55:02 -0400 http://www.medications.com/effect/view/21813?item=2093 Wash down with one ALKA-SELTZER in a small glass of water. Best & oldest system for most people. http://www.medications.com/effect/view/21813?item=2093