http://www.medications.com/effect/view/22822 I've been on TOPROL-XL( 50 mg) for about 18 months now. Gained 25 lbs. Lack of interest (consistently) in getting much done. I had an aortic valve replacement 12 years ago and they were recently concerned about an enlargement of the aorta-so they wanted t Fri, 10 Aug 2007 18:18:17 -0400 http://www.medications.com/effect/view/22822?item=1151 Same here re the weight gain. Then I read "You on a Diet" by Dr. Oz and found out why. Page 318 Appendix A, I quote: "Beta-blockers (which Toprol is), ... have been shown to cause weight gain AND decrease metabolic rate by 10%. " I too have an aorta proble http://www.medications.com/effect/view/22822?item=1151