http://www.medications.com/effect/view/23599 Prednisone is a catabolic steroid, not anabolic which increases muscle, so people should know that continued use over time will literally break down and destroy muscle tissue. Without muscle, a person has no way of even standing more than a few seconds an Wed, 19 Sep 2007 18:35:15 -0400 http://www.medications.com/effect/view/23599?item=1913 this has also happened to my husband. He has been on prednisone since February and has lost 25 pounds. His muscles are so weak. He looks like a skeleton. Most of the doctors just blow it off and say that prednisone causes weight gain, not weight loss, so http://www.medications.com/effect/view/23599?item=1913