http://www.medications.com/effect/view/27239 I took a zpak for bronchitis and a sinus infection. (lovely to have both at the same time...) I still had a fever three days into the five day cycle. After I finished the whole five day cycle I felt a LITTLE better, but a week later I developed fever and Wed, 27 Feb 2008 18:05:22 -0500 http://www.medications.com/effect/view/27239?item=5165 i too had a reaction to z-pack. started feeling very fatigued. urine became very dark. then headaches, then vomiting. blood pressure shot up. went to doc who ran blood work. liver enzimes very high. went to ER after about 4 days of not eating, sleep http://www.medications.com/effect/view/27239?item=5165