http://www.medications.com/effect/view/32196 Big weight gain in the past 6 months (40 pounds), sleeplessness at night, mental and physical fatigue, hand joint pain, feet pain. I was taking a low-dose anti-depressant, which I stopped taking. All symptoms remained. So, I'm going to stop taking 25mg HCTZ Sun, 01 Nov 2009 17:23:21 -0500 http://www.medications.com/effect/view/32196?item=24085 I was having similar symptoms and I quit taking the drug after reading this post and all the symptoms went away after a few days. http://www.medications.com/effect/view/32196?item=24085