http://www.medications.com/effect/view/32978 I started Doxycycline Hyclate several days ago (100 mg 2x daily) as part of 3 week regimen to treat Lyme Disease. I have had some stomach upset, a generally reduced appetite, and cottonmouth... but by far and large the biggest effect has been this overwhelm Sun, 17 Aug 2008 19:52:57 -0400 http://www.medications.com/effect/view/32978?item=11265 I have had similar problems. Taking Doxy for a sinus infection, but quit yesterday. I have felt stiff in my upper back and neck, instead of sweaty palms, I have sweaty feet. Go figure. I have been exhausted, when I wake up, I feel groggy like I can't fu http://www.medications.com/effect/view/32978?item=11265 Thu, 21 Aug 2008 23:24:23 -0400 http://www.medications.com/effect/view/32978?item=11452 I have experienced similiar side effects as yours. I am extremely exhausted. I went to the hospital and had multiple tests run as medical staff thought I was experiencing a heart attack, but all test results came back negative. I feel like someone has za http://www.medications.com/effect/view/32978?item=11452