Doxycycline Hyclate Side Effects: taking this drug for acne and have gained approx 15lbs has anybod http://www.medications.com/effect/view/33676 taking this drug for acne and have gained approx 15lbs has anybody else had this problem Doxcycline 100mg capsules. It happened to me. I got off it and about 3 weeks later im happy Mon, 08 Dec 2008 17:03:12 -0500 http://www.medications.com/effect/view/33676?item=15123 It happened to me. I got off it and about 3 weeks later im happy to report i lost the 11 pounds i gained :) http://www.medications.com/effect/view/33676?item=15123