http://www.medications.com/effect/view/33778 I had always been 160 lbs since 8th grade, which was a fine weight for me bacause I'm tall and muscular. When I was 25 I gained 20 lbs over 3 months with no change in diet or activity. So I went to the doctor because hypothyroidism is very prevelent in my Sat, 18 Oct 2008 23:10:13 -0400 http://www.medications.com/effect/view/33778?item=13598 I think there is a connection between weight gain and synthroid. I have gained about 18 pounds in three months and that includes the 3 weeks I was in Africa where (as an avid traveller I know) I should have lost weight. I'm going to quit my 50mcg and go http://www.medications.com/effect/view/33778?item=13598 Sat, 18 Oct 2008 23:11:01 -0400 http://www.medications.com/effect/view/33778?item=13599 I too think there is a connection to weight gain and synthroid. I'm going off my 50mcg tomorrow. Let you know the outcome. http://www.medications.com/effect/view/33778?item=13599