http://www.medications.com/effect/view/37137 I HAD BEEN TAKING LOTREL FOR OVER A YEAR AND DIDN'T KNOW THE SIDE AFFECTS. MY LEGS BECAME SO SWOLLEN THAT THEY STARTED TO WEEP WATER WHICH EVEN RAN DOWN MY LEGS INTO MY SHOES. MY DOCTOR NEVER EVEN THOUGHT TO APPLY THIS SIDE AFFECT TO THE LOTREL. I GAINED