http://www.medications.com/effect/view/37393 I hav been taking lisonopril now for four weeks. I feel very depressed--everyone keeps telling me that it is not the medicine, but nothing else has changed in my life. Mon, 13 Jul 2009 11:17:19 -0400 http://www.medications.com/effect/view/37393?item=21462 Are you sleeping well? I started waking up after 4 or 5 hours of sleep, wide awake. I knew this was not normal for me, and I was not ready to chalk it up to "aging" as doctors often try to do. I also had significant weight gain in abdomen / trunk area. http://www.medications.com/effect/view/37393?item=21462