http://www.medications.com/effect/view/39062 I have always had and currently have the side of effect of extreme fatigue associated with the use of synthroid and now Armour thyroid replacement as well. Whenever my tsh reaches normal levels I become increasingly fatigued. Now I an hardly stay out of th Thu, 13 Aug 2009 14:32:27 -0400 http://www.medications.com/effect/view/39062?item=22230 Yes, I have been on Synthroid since 2002. I had my thyroid removed due to a cold nodule. I still did not feel good, and matters got worse after a complete hysterectomy in 2004. I am now 39yrs old and struggle to maintain weight at 145 for 5'3. I was at http://www.medications.com/effect/view/39062?item=22230