http://www.medications.com/effect/view/39672 I have been on synthyroid for at least 7 years, and I still constantly battle fatigue and mood swings. All the doctors thought it was in my head and the last one suggested anti-depressants which I wouldn't go for. I feel depressed because I wake up tired Mon, 26 Oct 2009 13:52:42 -0400 http://www.medications.com/effect/view/39672?item=23841 This is just a thought but have you had a sleep test? I know some of the clients that I take care of (I am a Case Manager for Mental Health ) were having real problems with fatigue and sleep. They had a sleep study done and it was found that they had sle http://www.medications.com/effect/view/39672?item=23841