http://www.medications.com/effect/view/42022 I am on a 6 day treatment of PredniSONE 4mg for a foot injury that caused massive swelling. The swelling was gone after the first day of the treatment, but the side effects started the second day for me. I freaked out yesterday thinking that I was having Fri, 05 Jun 2009 08:43:57 -0400 http://www.medications.com/effect/view/42022?item=20380 Welcome to the prednisone jungle!! You are right on target for what usually happens. Dr's don't know squat about this med. You will be fine but it might take a few weeks. Hang in there!! http://www.medications.com/effect/view/42022?item=20380