http://www.medications.com/effect/view/4684 insidious weight gain - started taking Zoloft in 1997 (7 years ago) - weighed 123 lbs. Now 7 years later I weigh 143 pounds. It happened approximately every time I increased the dosage - 25, 50, 75. 100. 150, 200 mg - weight jumped to 128, 132, 135, 138,