http://www.medications.com/effect/view/4877 I have been gradually been put on Effexor XR. 1st week 1x37.5mg for 7 days then 2x37.5 mg 7 days or 2nd week then 3x 37.5 for 7 days and now 4x 37.5 or 150 mg. I have noticed a decrease in appetite as a matter of fact I've lost 14 lbs. in a month. I did hav