http://www.medications.com/se/Osteo+Bi-Flex+Plus+MSM Recent side effects for Osteo Bi-Flex Plus MSM Sat, 08 Sep 2007 20:53:12 -0400 http://www.medications.com/effect/view/23476 After using Osteo Bi-Flex with MSM for only 2 days and not changing anything else in my life, I broke out with a rash and persistent itching around my knuckles, wrists, elbows, knees, and feet. A spot on my right wrist swelled to the size of a siler dollar http://www.medications.com/effect/view/23476