Amoxicillin and sinus infections

I am a male in my 30s and I am predisposed to situational anxiety hypersensitivity and phase of life triggered depression. 90% of the year I am fine with no problems with depression or anxiety. I have had 6 treatments of amoxicillin over the last 2 years for sinus infections and wisdom tooth extractions. In each case, within 72 hours of the start of treatment, I experience constant depressed mood and hopeless and experience evening crying spells as a release from severe depression all day. In all 6 cases, within 48 hours of the last dose of amoxicillin, the depression subsides and my mood reaches a normal state. My doctor at the time did not attribute the depression to the antibiotic since I suspect it isn't listed in his PDR and did not show up with statistical significance in clinical trials. I don't go to that doctor any longer due to this and have a new doctor that has 20 years of experience and noted a lot of anecdotal evidence of amoxicillin triggering depression in those that might be predisposed to situational anxiety, panic attacks and/or stress/phase of life induced depression.

Both my children, girls ages 6 and 9 are currently taking 800 mg. a day of Amoxicillin for double sinus infections. My girls are normally upbeat, happy kids and I have noticed that over the last several days they seem gloomy, quiet, fatigued and frankly rather depressed. As this is unusual for them, I can't help but think it is the medication. I can't wait until they finish the dose.

Generally begin to experience relief from sinus infections after 5 doses, nearly 24 hours' worth (of 250mg 3X daily). Amoxicillin typically exacerbates viral/fungal type symptoms that occur when I have any kind of infection or lowered resistance (two or three small pimples on tip of nose, itchy scalp, mild tinea pedis between 4th and 5th toes which I never get otherwise, and slight flaring of a nearly invisible planter's wart which I've had since I was a teen. Amoxicillin also provokes a mild depression similar to pms symptoms, potential weepiness if provoked, and, in the last two years (perhaps because I may be--at 51-- approaching menopause), hot flashes. Because I can develop extremely serious sinus and/or impacted sinus infections, I'm glad for various antibiotics (1-3 times annually), but I can't say that I always like the side affects.