Crestor side effects

I recently lost my brother Marty to ALS. Marty asked me to tell everyone about his experience and I promised I would. Marty began taking statin drugs in his early 40's. He took them off and on at the suggestion of his PCP. It began with Lipitor and progressed to Crestor. In Dec of 06 tests revealed elevated muscle enzymes, he was also having pain in his left leg. His PCP called and told him to discontinue the Crestor, which he did. The pain continued and other symptoms began to materialize. Symptoms included muscle weakness, toe drop, fasciculations and continued pain in his leg. In June 07 after many tests he received the diagnosis of ALS. He passed away in August 08 at age 52. He believed as I do that statins caused this most horrible disease in him. He also believed that cholesterol is a symptom not the causal agent of heart disease. Now you must decide.

Took 1 dose. Within hours, I awoke with a very dry mouth and severe heartburn. Went to the kitchen for water and nearly passed out. Nausea, so I made it to the bathroom. Cold sweats, then chills. Felt like I had the flu. Every time I stood up, I nearly passed out and kept having same symptoms most of the night. Next day, at work, I had to be taken to the nurse, who figured out that my already low blood pressure was dropping dramatically when I stood up (as well as my pulse rate increasing). I threw up all over the doctor's bathroom. Still feel awful 3 days later. Dr. pretty much indicated that blood pressure drop couldn't have been from the Crestor, although my father has had same thing happen with EVERY statin they've put him on. Now, my leg aches and my urine is dark

Over 6 years ago, the following Petition was submitted to the FDA, I would encourage every patient being treated with statins to read it and bring it to the immediate attention of their physician:

CITIZEN PETITION TO CHANGE THE LABELING FOR
ALL STATIN DRUGS (MEVACOR, LESCOL, PRAVACHOL, ZOCOR, LIPITOR, AND ADVICOR) RECOMMENDING USE OF
100-200mg PER DAY OF SUPPLEMENTAL CO-ENZYME Q10 TO REDUCE THE RISK OF STATIN-INDUCED MYOPATHIES (INCLUDING
CARDIOMYOPATHY AND CONGESTIVE HEART FAILURE). http://www.fda.gov/OHRMS/DOCKETS/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf
May 24, 2002
Petitioner:
Dr. Julian M. Whitaker, M.D.

This Petition is based in part on the clinical findings of Dr Peter H. Langsjoen, MD, FAAC,

Over 6 years ago, the following Petition was submitted to the FDA, I would encourage every patient being treated with statins to read it and bring it to the immediate attention of their physician:

CITIZEN PETITION TO CHANGE THE LABELING FOR
ALL STATIN DRUGS (MEVACOR, LESCOL, PRAVACHOL, ZOCOR, LIPITOR, AND ADVICOR) RECOMMENDING USE OF
100-200mg PER DAY OF SUPPLEMENTAL CO-ENZYME Q10 TO REDUCE THE RISK OF STATIN-INDUCED MYOPATHIES (INCLUDING
CARDIOMYOPATHY AND CONGESTIVE HEART FAILURE). http://www.fda.gov/OHRMS/DOCKETS/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf
May 24, 2002
Petitioner:
Dr. Julian M. Whitaker, M.D.

This Petition is based in part on the clinical findings and safety concerns of Dr Peter H. Langsjoen, MD, FAAC

Statins kill people - lots of people - and they wound many, many more. All patients taking statins become depleted in Coenzyme Q10 (CoQ10), eventually - those patients who start with a relatively low CoQ10 levels (the elderly and patients with heart failure) begin to manifest signs/symptoms of CoQ10 deficiency relatively rapidly - in 6 to 12 months. Younger, healthier people who's only "illness" is the non-illness "hypercholesterolemia" can tolerate statins for several years before getting into trouble with fatigue, muscle weakness and soreness (usually with normal muscle enzyme CPK tests) and most ominously - heart failure. In my practice of 17 years in Tyler, Texas, I have seen a frightening increase in heart failure secondary to statin usage, "statin cardiomyopathy". Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.

Hello, I have been taking Crestor over a year it is causing so many problems now! I have clots of blood passing & terrible burning when urinating. I went for pap smear, pelvic examine this week told everything is good. Heart doctor took blood test said great keep doing what you are doing. I read on line that Crestor should be taken off the market. Also causing tearing and damaging the lining of the bladder which doesn't show with urine test, or my blood test.
Crestor causes eye damage, twitching, depression and a list as long as my leg and I have very long legs!!!! BEWARE of CRESTOR!!!
I am seeing my heart doctor this coming week and trying to get away from it.
I want Centrum Cario vitamin supplement!!

I am 42 years old and been taking crestor 10 mg for about 18 months to 2 years.. Recently been feeling tired with heavy legs.. told my doctor did a blood test everything was normal.. doctor advised to get off crestor its been 3 week and still feeling tired in legs.. am pretty active, workout , lift weights.. walk and play golf lately 18 holes carrying bag are becoming difficult.. will stay off crestor for a while and see if leg pain and tiredness goes away.. Anyone experienced similar systems... What did you do... My cholesterol on crestor had dropped to 160.. last test while on crestor was 238 hdl 133 and ldl 64.... not sure what to do but till i don't feel normal do not plan to take crestor as that is the only medication was taking....

April 27, 2008 9:21 PM
My dad has been taking Crestor for a few months now & he has complained of his left arm being numb for about a month now. It does not seem to get any better and now his legs are giving out on him. He says he can't hardly lift them to walk--like the are really heavy. I'm thinking this is side effects from the Crestor but the Dr. says it wouldn't cause that. They haven't ran any tests on him. After reading from several websites on Crestor I am convinced it is the culprit.

After taking 10 mg of Crestor for a short time, i experienced shortness of breath and was very tired. This continued even thou the doctor said it was not a problem. I finally got in to see him and they had me immediately quit the drug and I was sent for a echo/stress test. My heart rate had dropped so low and my breathing so labored, that I was considering suicide, there was no way I was going to go on living if all that I could do was to wake up and get dressed and be so tired , that I was unable to function at all.

I began taking 10mg per day of Crestor on 19th May this year. I received the documentation regarding side effects and read it. After two days I had tingling pains in my legs and I was checked for further cardiovascular problems, and cleared. I enquired if Crestor may be the problem but I was assured it was not.
I had a CT scan and then subsequently an MRI of my lower back looking for restricted blood flow but after seeing a neurosurgeon this was ruled out as the cause of the tingling. There was some degeneration of the back but not serious blood flow restriction. At about this time the Crestor dosage was increased to 20mg. At this stage I had back pain but it was not thought to be related. I enquired again if it might be Crestor but was assured it most unlikely.
Pain in my back increased dramatically one night shortly after and was so intense not only could I not sleep, I simply could not get myself to think of anything else despite intense mental energy to try to do so. I was on the verge of calling an ambulance, but walking around and applying heat seemed to relieve it slightly and I lasted until morning. Doctor thought it was a locked facet joint and sent me to a physio. She helped considerably and I assumed this was the problem. However, the next day it returned. Upper body strength was fine but from the middle down was just plain sore. The physio worked on my back again, and suggested I get a back brace which I did and I struggled on with that as a help.
The pain shifted from my back to the top of my hip and I went back to the doctor to check my hip. He assured me the pain was on the top of the hip, not the groin area and was unlikely to be my hip. I began taking over the counter pain killers for the pain which was hitting about 8 out of 10 spasmodically. The physio was mystified and suggested it may be kidney stones, and so I went back to the doctor to check that out. He had already taken a urine sample which had no blood at all. The pain shifted to the hip and upper right leg. By the time I was able to see him, the pain was quite severe and I was sure it was my hip. He was not sure, but prescribed Panadine Forte for the pain and sent me for an Xray of the hips.
I was very distressed about this, as it appeared I would not be able to continue working. The hip Xray showed perfectly normal hips but the pain was even worse, by this stage in the right thigh. In desparation I saw the doctor again and agreed to try and “tough it out for a few days” using pain killers, another round with the physio, and as much rest as possible. The physio was so convinced it was not muscular but rather a possible kidney stone she sent me back to the doctor. While waiting to get to see him I began looking at the side effects of Crestor on the internet and after checking with the doctor I stopped taking it on Aug 1st to see what happened. Within a day I began to improve but I still thought it might be kidney stones (possibly a big one blocking a tube completely and therefore no blood) and my doctor ordered a CT scan of the bladder area which confirmed that both kidneys were working just fine.
Slowly over a week and a half the pain is completely gone, the back is fine, the hips are fine, the groin is fine and I feel so much more like living. I am now absolutely certain it is Crestor that has caused the whole problem. The docotrs have now prescribed Lipitor in it’s place, and I have the tablets but as yet I have not begun taking them. I am a bit fearful of doing so, but I will begin in a few days time. However, if I get any repeat of the muscular problems I have had I will stop immediately.
I decided to document this as I realise this is important feedback concerning a relatively new drug. I don’t know how this is conveyed to a national data base, but it seems to me this is a serious side effect that has very nasty consequences. Was it that my kidneys were objecting violently to the drug? I don’t know. But it caused me great distress and this is surely a concern.