Doxycycline Hyclate and panic attack

I started taking Doxycycline Hyclate 100mg on oct 25,2009. I have had anxiety, its been something i have been battling with up until 2 years ago and since then i have had no anxiety attacks. When i started taking the doxycycline, i started to become anxious and starting having anxiety once again. I have also become very shaky, i have a hard time swallowing pills so i brake the capsule open and put it my cup, put just a little bit of water in there and mix it around. could this affect the way the medicine is suppose to work. i have no other option because i have to take it to clear my infection, but i don't want it to harm me. please email me at ****** if you can help.

Within 12 hours of my first dose, I started experiencing irritability, racing of thoughts, rapid heart beat, shortness of breath, nausea, sweating, and then ultimately, a panic attack. I have history of successfully treated depression from several years ago, yet this med brought forth all those painful old feelings of angst. I am discontinuing doxy immediately. I wish that one of the warning labels on the Rx bottle read, "Do not take if there is a history of depression." It sounds like that would have save a lot of people a lot of grief. Best wishes to all for good health.

Until yesterday, I took 14 days of a 4 week prescription of 100 mg twice a day doxycycline for a tick bite rash. I rarely take any medication. The first week I just had mild side affects. Late in the second week I started to notice that I was becoming increasing anxious for no apparent reason. Even after hard exercise the anxiety seemed to be persistent as if an impending panic attack. Yet, I had no external reason to explain the anxiety.

After two additional days the anxiety seemed to keep ramping up and I began to get very dizzy when I moved suddenly or bent down to pick up items from the floor. The pressure behind my eyes also feel like it was increasing. I was afraid my blood pressure was spiking but in actuality it was probably either cranial pressure or simply an fight or flight anxiety response. I also experience some pretty vivid dreams.

I finally searched online and found no official symptom of anxiety for doxycycline but found people complaining about it unofficially. I spoke with my pharmacist who also said she had no listing of anxiety as a known symptom for the drug. She suggested I stop taking it and see if my symptom subside.

It has been 24 hours since my last dose and the anxiety has reduced substantially but not completely. I feel like I have a hang over today but otherwise I do feel an immediate improvement. I am still a little dizzy but not like yesterday.

Like all drugs, you should be very cognizant of how the drug affects your body - even if a physician tells you otherwise because only you can really tell and everyone has different bio-chemistry which reacts in different ways to different drug compounds.

started this 7 days ago for a prostate infection... I thought i've been going crazy this week until i saw this post..im having a horrible reaction to this stuff..although it does seem to help my prostate...it leaves the rest of me in bad shape. First off ive been getting lightheaded like every other day to the point as i think im have a panic attack but heart isn't racing...I've gotten diarrhea 3-5 times a day i go now...i had a bagel the other day for breakfast..it was the hardest thing to eat as i felt sick to my stomach and knew i had to eat something so forced it in..today i had a banana and some grapes and 15 minutes later was throwing it all up. I just called my doctor and asked for a change in antibiotics as this thing has lead me to believe there was something wrong with me although my doctor seems to think these side effects don't generally happen...i come here and see they happen EXACTLY how i have been feeling and just hope this doesn't last much longer in my system!

me too. I am glad to hear I'm not alone. everyone else thinks i'm nuts. MY anxiety has been through the roof on this stuff ( i almost went to the er last night thinking I was having a heart attack, but decided it was a panic attack) I have been extremely light headed, dizzy and very jittery, my chest hurts. Im done with this crap.

Please can anyone who has suffered anxiety/panic/depression/suicide on Doxy tell me how long after stopping taking it this went away???

DO NOT TAKE DOXYCYCLINE IF YOU HAVE ANY HISTORY OF DEPRESSION!!!

I do and doxy has sent me over the edge for about a month AFTER i stopped taking it.

I was given doxy by my doctor for a sinus infection for a week and stopped taking it just under a month ago. This past month has been absolute hell for me.

The day I stopped taking it I went from feeling fine into a 5 hour crying fit with suicidal thoughts in less than 30 minutes. During the fit I became convinced that this was how my life always is, that I was depressed, that I had always been depressed and that I needed anti depressant as I spend all my time crying. That was on 2nd Feb.

The next day I was shaky and felt very up and downy but went back to feeling normal pretty quickly and after I did some internet research on Doxycycline (the only change in my diet/lifestyle) assumed it was that. I read some pretty bad stuff on the internet about other people’s experiences which were very similar to the one I had had and I thought that must be it.

So I decided to drink lots of water and have been taking Milk Thistle to cleanse my liver.

Then this Saturday past I had exactly the same thing. I had another one of these 5 hour crying fits and more suicidal thoughts and I became convinced I was bipolar. This time was much worse in a lot of ways.

I felt it again felt like a panic attack and to me the change in my physiology was really noticeable. The noticeable dip in my mood – very sudden from feeling fine to feeling a little bit irritable and then withdrawn with some anxiety – and wanting to be reassured but also being a little aggressive in communication almost like trying to find a fight, then a change in breathing and heart rate and then plunge into dark thoughts and sobbing.

When I went to see the doctor on Monday my mood was still swinging up and down and I just felt crazy so I mentioend to him the doxy and he dismissed this without even asking a question about when or how much I'd taken.

I ask to be referred to a psychiatrist as I do get that I may have underlying issues and these mood swings were so bad and so strong and so by the time Wednesday came with my in and out moods I had convinced myself it was probably to do with my childhood and the difficult heart stuff and repressing how I really feel

Whilst I do have my fair share of childhood stuff and issues of the heart I think I’ve become so self aware and so careful with myself and I think I talk to my inner child so much and check that I am okay with things and I deal with things really well. so this has all come as a bit of nasty shock as I thought I was okay with everything. In fact I know I’m okay with everything as I write this.

But during these mood swings I am definitely not okay. I do not feel like myself. I become convinced that I have been lying to myself about being okay, that I have never been okay that I am mentally ill and that is why I am having mood swings and I start really analyzing everything and linking everything back to the past and trying to make links with things that are happening today and things that happened in the past. I haven’t had any change in my heart situation that this could be a reaction to, its remained the same for a number of months and I don’t have a problem with it but when I have this mood swing I blame that situation and my childhood together. I start wanting to blame people. I start thinking I have two personalities and I just start trying to find reasons and I have no idea what I feel, who I am or what I want, if I’m telling the truth of if I’ve ever told the truth. I start doubting everything and everyone. My head hurts, I get in a state of confusion and I become a little mean to people. I start trying to blame events and situations, anything I can find. It’s an absolute nightmare. Then I get confused about what I have and haven’t said and agitated that I need to say more to make myself understood. I might be stable for hours or even a day but it happens very suddenly and it’s a really physical sensation, first the dip in mood, the irritability, the breathing will change, I will feel anxious and can really feel my heart beating, like when you are really scared about something – that fight or flight feelings. I then get a really strong sense of insecurity and nervousness and will become really awkward at communication and almost aggressive and rude in my communications and then rueful.

The crazy thing is my mood is just absolutely all over the place in a way it has never ever been before, even in my days of deepest darkest moments when everything in life sucked and people were horrid to me. I don’t understand why I would, after all my years of learning how to deal with this and cope with this be even worse when my situation is so much better. It just doesn’t feel like its actually real. I don’t feel like anything I’ve said when I’ve been in these moods is actually a true reflection of how I feel when I am out of the swing.

Then I come back to feeling more like a version of myself but not quite and then I swing again very quickly and go from very hyper and laughing to almost the polar opposite in a very short space of time.

This is the first time in a week that I’ve felt like I am completely normal again. Right now I feel very calm and grounded and rational like I have been feeling for a very long time and I feel very clear in my head that I am completely fine and this is a reaction to some chemicals in my body affecting my mood rather than a psychological issue.

I am fully prepared for another full scale attack of mood swings and totally losing the plot again though.

I am lucky in that I have a good friend who called a doctor friend of his in the US and the first thing the doctor friend said when asked about Doxycline was 'don't tell me, you know someone who's had anxiety attacks and suicidal reactions'. According to this doctor this is VERY common and very well documented. There should be no lasting effects or permanent damage and now the doxy is out of my system I should not be experiencing these moods swings.

HOWEVER - he thins that because I have a history of depression due to my childhood issues the doxy has basically destabilised me and driven me to the edge again.

I did some really lengthy research because I really feel like this is a brain chemistry issue rather than a psychology issue and knowing I've dealt with everything and I just don't get why these issues would re-arise. I'm going to go get some therapy no matter what but I just wanted to know the brain chemistry.

Obviously if my GP doesnt even recognise that doxy can have this affect there is going to be no interest in helping me figure this out so I will figure it out myself.

From what I can understand Doxy decreases some amino acids in the brain which is important as simply put, amino acids get converted into neurotransmitters which play a critical role in your brain. Neurotransmitters are the chemicals which help your brain cells 'talk' to each other. Low levels of certain neurotransmitters have been associated with depression and anxiety.

I feel like I am 'back' from the Doxy but to be honest, I have no idea what it has done to my brain and I doubt there has been that much research into it...if so why on earth would they prescribe a drug that does this to people?
Particularly people who have a history of depression.

I am going to try taking amino acids to see if that helps - it can't hurt.

If anyone else is going through the same thing please get in touch and let me know!
This site totally helped me!! Thank you everyone who has posted on it. It really makes a huge difference to know that there are other people out there going through the same thing. I have felt like I am absolutely crazy! Thank you so much :-)

February 22nd
2009
My side effects (Charles Clark)
3:00pm

It started with diarrhea after a couple days treatment. Then my hand muscles starting to contract on there own. Then I started having high blood pressure up to 212/118 and high heart rate and anxiety beginning to set in. My wife wanted to take me to the hospital but I refused to go (I wish I had. They might have taken me off Doxy then, but no, I was still taking it). I then started having problems breathing (like something was stopping me. Not like hyperventilating). My wife called the doctor and she said to stop the Doxy and come in. At the visit, she gave me meds for high blood pressure and ordered a heart monitor and stress test as she believed my problem was more likely with my heart. I didn't start the blood pressure medications as I needed to have the tests done in a week and a half. I had a panic attack before the stress test. There was a patient there who stated her granddaughter had developed panic attacks after she had taken Doxy for Lymes disease. What a coincidence. That weekend my blood pressure and anxiety increased and my wife called the doctor. They convinced me to start the blood pressure medicine as all of this might be caused by High Blood Pressure. I returned to the doctor 4 days later and she took more blood work as well as tested for Lymes disease again. Everything was normal and NO lymes disease. So what was causing all of these problems. That night when I came home from the Doctors I started feeling like someone just sprayed me like you spray a wasp/bee. I started to shake and twitch inside like I was dying I could feel my stomach convulsing and getting cold. Now at this point I had been off Doxycycline for a few days. My wife called the doctors emergency line and they called in a prescription for Xanex. I took it and it put be out. I woke up the next day feeling like I was on a bad rollercoaster ride going over the edge and trying to climbing out of my skin. I was unable to even take care of myself at this point. I started getting muscle twitches all over my body. I could not control my thoughts and had a hard time talking; my skin was so hypersensitive to the touch or movement. The only way I could deal with it was just lay down and not move. I felt like was going to die. More symptoms came: my middle finger on my left hand went numb; I was so nauseated I had a hard time eating; depression set in with sever panic attacks/anxiety, ears ringing, slight pain in my chest like I was having a heart attack and was becoming bed ridden and afraid of everything at this point. That next week I returned to the doctor and she noted how it seemed a struggle for me to walk into the office. She felt that I should begin meds to decrease the anxiety that was paralyzing me. She suggested seeing a psychiatrist and stated that if I got worse my wife should take me to the emergency and be admitted to the mental health program. So I began to take Paxil as well (I hate medications, but I was desperate). I was terrified that I might have side affects from these meds and I couldn't be alone and I was afraid to go anywhere, afraid I would have an attack or worse, stop breathing all together. I was terrified and my family was getting very worried about me and unsure what to do. Thanks to my best friend, my wife, and my family for taking care of me. If it were not for them, I would not know what to do. My dear mom even came in from Virginia to help take care of me. I can not express my thanks enough to my family! I have been off the drug now for almost seven weeks now and all my side effects are slowly, very slowly, dissipating. How come the Doctors don't know about this? Thank GOD for this site and the ones that took the time to post there experience with this drug! THANKS EVERYONE GOD BLESS YOU!

P.S. please reply on what you did to get rid of the side effects, how long did it take for them to go away and did your Doctor believe that the Doxycycline caused them. because I can't find a Doctor that thinks the Doxycycline can have these side effects.

Thank God for you all that posted! :) I don't feel all alone. I'm usually a healthy, strong guy that rarely complains. I've been on a 100mg 2x a day dose of doxy. The first week was ok. just minor stomach nausea. Then i noticed chest tightness, mood changes ( and on the norm im a really passive guy, in a good mood) dizziness, very scary panic attacks(mind racing with negative thoughts), headaches.. Its my 2nd day off of it. Still feeling nausea.. sharp abdomen pains, in and out of depression. I truly hope this thing goes away asap. Never again will i take this med. Very scary times.

Thanx for this site. I took Doxy for 3 days (100mg twice a day) and i woke up with a terrible headache on my right forehead. I took ibuprofen then my left hand started shaking and my heart was beating so fast. I ended up calling 911 thinking something was more serious with me but by the time the paramedics came my pulse and heart beat were normal. Almost 48 hours later i still had the headache and now was having shortness of breath, feeling tired, back ache, panic attack and light headedness. I called my DR and she said i probably just needed some rest. No mention of some possible side effect to doxy so i used my initiative and googled this stupid doxy drug..Wow the results were very helpful and now i know its the doxy doing this to me for sure. I stopped taking it right away which is after only 3 days after but my body hasn't gone back to normal. No more shortness of breath but still have back ache, Oh and for some reason i cant sleep..its 5 am right now and am on my computer..so i think i'll add insomnia to the list of side effects..NEVER AGAIN WILL I TAKE DOXY

Thank you so much for this site and your posts. I am on my 4th day of doxy. and I had a panic attack today and anxiety--I was doing fine until now. I would consider myself a calm person so this caught me out of the blue. I called the pharmacist who thought I was nuts, I'm sure. She said it was not a side effect of the drug!! I also noticed some nerve pain over my body. But my infection is lots better so I don't want to stop, but I don't want to have panic, either or get sicker.

I also get the stomach queasiness when taking a dose and always eat a slice of bread with it. I have noticed a worsening of reflux and I make sure to sit upright for at least an hour after taking the medication.

I took this medication as a malarial prevention whilst traveling through India.
Never EVER again. My boyfriend had suffered from depression in the past and we had heard bad things about Larium in relation to anxiety and insomnia so we specifically asked our doctor for the malarial tablets with the least amount of side effects associated with that kind of stuff. He reassured us that there was no record of Doxcycline ever having caused those sorts of effects.
So off we went- we followed the instructions exactly and began our trip.
A week or so into India I began to notice shortness of breath and stomach pain- I put it down to typical India travelers upset and thought no more about it. A bit later I began to suffer moments of anxiety that were really out of character ( I've never suffered from anxiety or depression). I'm very well traveled ( I work in the travel industry and have traveled extensively in the Americas, Africa, Australasia and se Asia) and so although this was my first trip to India- i knew my anxiety had nothing to do with India itself. ( people kept telling me this but I loved India)
It came to a head on a overnight bus from Goa to Hampi- I was feeling really anxious, sweating and clammy, I couldn't sleep and my breathing was really tight. Eventually I had a full blown panic attack that was almost like a out of body experience- I couldn't see and I couldn't breath. The whole bus had to stop ( embarrassing!) at 3am in the morning. Eventually I managed to get back on and make it to the next town ( although not as far as Hampi) so we could take stock.
I was petrified and had no idea whatsoever what was going on. It never occurred to me it could be the malaria tablets as we had been so clear and our doctor so confident they didn't have these kinds of side effects.
I was worried about being on buses, trains even planes again since I didn't know what caused the attacks and I was terrified another one would happen. I had no valium or any other sort of thing that might have helped. In the end we had to cut our trip short and make it back to Mumbai - In Mumbai I suffered from another two panic attacks- one where I could see the walls closing in in our cheap hotel room. Shortness of breath, tightness all through my body, hysteria, blurry vision - it was awful! And also this ongoing pain and upset in my stomach.
I ended up cutting short a RTW trip that my boyfriend and I had been saving for for over a year and coming home to Australia 2 months early.
It was devastating and I still had no idea what was causing it. Finally a friend said her doctor had mentioned sleeplessness and anxiety as a rare side effect of this drug when she was taking it for some problems to do with vaginal bleeding and spotting. I started searching on the internet and was amazed to find loads of sights with people experiencing heaps of the side effects that I'd been told were never a problem with this drug!
Obviously Malaria is really serious but if I had been properly informed I could have made the decision to come off the drugs and look at alternate medication. For now - Im taking the risk of no malaria tablets at all for my next couple of trips (to Borneo- so not a major risk anyway) and will actually research much harder before taking anything again!

I had a gonhorea .. i take doxy for 7 days . then i had diahrea and i feel bad , skin iritation on some body places spicialy in axilary in both arms , spasm in gastregnemuis muscle in legs and i feel vertigo , and abnormality in larynx also my tongue become white , panic attack. pain in testes and pain the the place of seminal viscal
what is this? did i have a viral disease? i made liver function thest and hepatitis and AIDS but the result was negative and normal.. and i have to wait to repait the test.

i am confused and live in panic !!

I was placed on Doxycylcine for Epididymitis, which is an inflammation or infection of the epididymis, a convoluted duct that lies on the posterior surface of the testicle. I took Doxycycline for one week. 100 mg twice daily. I ate a meal with every pill. I did not experience nausea or vomiting like I see many did. I did however have fatigue, loss of appetite, diarreha, increased anxiety (I have anxiety and panic attacks), depression, agitation, pains shooting down the back of my quadriceps, abdominal pain and some acid reflux type symptoms towards the 4 th day of taking this drug. It has been a little over a week since I finsihed this drug and I am still having pains down my right leg in in different places, when I sit or lay down is when it is most painful. The doctor can only describe it as a possible slipped disc. How? I was bed ridden for a week! The pain in my leg is not severe but very annoying! Like others here my doctor says that he does not see how Doxcycline could cause this. I will never take this drug again! I will from now on request Zithromax. I have had to use Zithromax quite a few times in my life and have had no problems with it.

am taking 100 dox 2x daily for 2 weeks after being bitten by a tick. wasn't concerned when they told me to start this medicine, didn't expect much in the way of side effects. i will also add that take thyroid meds and they were adjusted downward 3 weeks ago.

i am also being menopause. The first things i noticed were the hot and cold sweats. bone chilling deep inside you cold. menpause? Then the ringing in the ears. Waking up hungry in the middle of the night after the anorexic effect of the medicine wore off. blurred vision ans swollen face. not enough to tell the doctor, but around my eyes especially.

A couple of nights panic attacks and sleeping but not really knowing it. Next came the waking up dizzy with the bad headaches and or having neausa and stomache aches after taking it.

irritability on occasions as well as chest pains. was surprised at my low level of tolerance to noise. i'm stopping this today even though have just one day left.

Hello everyone,
First of all, let me tell you how happy I am to have found this website.
I have been prescribed Doxy for a Bronchitis and the very next day I started experiencing the temperature swings, the drowsiness, the sleeplessness, the sore throat, the mild nausea, the sound and light sensitivity, the weird pasty feeling in my leggs, the loss of appetite and most of all : the chest pressure right between the lungs that varies in severity, to the point where the doctor thought I was having an anxiety/panic attack !!!
Believe me, I am not prone to anxiety or panic attacks, I have faced very stressfull situations in the past with no such thing, yet it really felt like one.
I took this med for 6 days, the 7th day I stopped it. Almost right away most of the side effects are gone, but the chest pressure, which is persisting.
If anyone experienced this before or knows of it, how long will it take to clear up ? And is there anything to help it go away faster ? as I am getting ready to take finals and it is really distracting.

Thank you for reading and I hope you all feel better soon.

Cheers-

Took Doxycyline for possible Lyme. I am bipolar. I had tightness in the face and mild headaches. Ground my teeth a real lot. Worst was I had anxiety/panic attacks so bad I couldn't work. I lost a lot of money because I was afraid to go on a roof that I built. Doxycyline set off my manic episodes with 24 hours.

I had taken doxycycline for malaria prevention . After taking it for 3 weeks, I started feeling sick. I was getting dizzy spells and a constant cloudiness in my head. I also experienced anxiety and panic attacks. I felt it difficult to concentrate and was very sensitive to noises.There were days that I couldnt function and just wanted to sleep all the time.I stopped taking it 10 days and am starting to feel better only now. My advice to anyone taken doxycycline is to STOP it immediately. I have spent loads of money trying to find out what was wrong with me