Estradiol side effects

i was on estratest for years, and recently my pcp switched me to estradiol. i am experiencing itching, weight gain, and hot flashes.

I have confusion.Difficulty speaking certain words.Memory seems altered.I have been using the tablets of estradiol for almost a year My problems seem to be increasing in severity. I use this medication due to hysterectomy. I am 47 years old.I also wake up at night with horrible itching on legs.,ankles,knees.What do you think.Possible reaction?.

When I skip a dose or two - like on the weekends when my schedule is out of whack - I get a bad headache.

When I use the tanning bed, I start to itch all over and several people have told me that it may be the estradiol pills that I take on a daily basis for hystorectomy three years ago. Is this the cause of the itching or could it be from something else?