Januvia and metformin

My husband was diagnosed with Type2 diabetes Sept. 30, 2008. He took the Janumet 50/1000 samples 2 times a day like the doctor told him to. His bs was very good (less than 110). He then switched to 50/500 about the 3rd week of October. His bs still fine. But he started having diarrhea many times a day and through the night.

He quit taking the janumet and about 5-6 days later the diarrhea changed to soft bm's. And he started to feel better, and then his bs would go up again. So he took 2 days of Janumet, diarrhea for 5-6 days(and not taking J.).

The doctor gave him separate prescriptions for januvia and metformin. My husband took 2 half pills a day of the januvia(100mg). and after 2 days, the diarrhea started again.

This is awful, just awful!

L., wife of a truck driver

November, 2008 I started Januvia about 3 months ago while also taking metformin, glimeride. I previously took Actos but was gaining a lot of weight. Actos replaced the Avandia. The first few weeks on Avandia I seemed fine and the bs was okay. Gradually it increased along with severe painful spasms in my legs, trunk and daily in my neck. Eventually my hands began cramping. I also became severely constipated which is quite unusual for me. I then developed a series of upper respiratory infections. Since I was feeling awful I decided to research Januvia and its side effects. The manufacturer mentions the infections but not the others. As an experiment, I stopped taking the Januvia and within about 5 days, the painful leg/trunk spasms began to disappear. I'm contacting my doctor this week to find me a new drug....hopefully not insulin.

I've had pancreatitis 4 times since starting Januvia, coughing up blood, nausea, vomiting, aches and pains, can't sleep at night, and a host of other symptoms. 4 days without and I'm beginning to feel normal again.

the samples from the doctor worked great! started a new bottle of another 3 months supply, and BS went to 400! a week ago, started to get hives every 3-4 days.now, every day at night, 12 hrs. after taking Januvia, hives break out on back. waist, buttocks, arms.was in ER yesterday, they said rash from Januvia unlikely, because they HAVEN'T SEEN IT BEFORE. After insulin injections, BS only got down to 295. Afraid to eat, 9 hrs. later had a tomato and cucumber sandwich, and BS went back up to 360. My doctor added Metformin to Januvia, and I am now once again with horrible diarrhea, after only one dose of 500mg Met. BS is still sky high, and the ER didn't seem too concerned. Anyone ever hear of hives from Januvia? HELP!!

Wow. I started taking this when it first came out, a couple of years ago. I had DM w/uncontrollable BS's. BS's came down significantly. But now, a couple of years later, I've been experiencing a few night terrors, when first put on insulin and Januvia, I gained 20# and can't! get them off. I also have fibromyalgia,...so I didn't even think about the Januvia possibly accelerating, increasing, or changing what was going on with the fibro.

I get violently sick anything with Metformin, and swell up like an air balloon (gained 50! lbs. on the Avandia & Actos (MD screwed up and gave me both in maximum dose--I've had leg swelling ever since.) Anyone have any leg swelling/edema? They keep trying to put me on anti-depressants..I've had "real" depression before, and I don't have that kind of feeling, just exhausted, like I can't get going...fibro...or Januvia?

After reading a

Has anyone experienced excessive weight gain using Januvia? About 13 months ago I started taking J. and I've not lost any weight since that time. I had Lap-band surgery 19 months ago lost 58 lbs the first 7 months, started the Januvia, had what I thought was Lap-band problems, gained a few pounds and the few pounds are now a plus 40. I've spoken to a pharmacist and he says there cannot be any connection to Januvia, however I've begun to question Januvia as the advertisements on TV state that Januvia has not been tested with insulin and I'm taking Lantus at night and Januvia in AM. Januvia can be used with insulin at the description of the Doctor???? I'm very concerned about myself and Januvia. Any comments 2bears

I was taking Avandia since I found out I had Diabetes in 2000 . After all the bad news that was confirmed in 2007, I switched to Metformin then to Metformin and Januvia. The first three months after taking the Januvia, my blood pressure was high and the protein level in my urine increased. I was taking the Enalipril for at least 5 years for my kidneys . I never had high blood pressure. My doctor increased the Enalipril and three months later my blood pressure was still high and protein level more than doubled. I think there is a strong connection because it started right after I stated taking the Januvia. Any one else have this happen?

I was taking Metformin(500mgs) and my sugars were very good. I told my doctor about 1 bad reading and she told me to try a new medication (Januvia). Since then I have trouble sleeping, wake up 4-5 times in 5 hrs and feel edgy all day. I take reequip for restless leg syndrome and it's been working, but now I feel like it's back and I know it's JANUVIA. I'm going to tell my doctor to switch me back to Januvia.

I hve been on Januvia for 5 weeks, after not being able to tolerate Metformin. I have noticed a great thinning of my hair. Other than that I haven't felt better. Is hair loss a side effect?

I've been taking Januvia for 8 weeks, and have experienced muscle cramps with shock-like pain running down my leg into my heel; upper and lower GI spasms; night sweats with sleep interruption; and I gained 5 pounds in the first 4 weeks which I can't attribute to anything else. I've also taking metformin and glyset for several years, and although I've experienced the night sweats, they've greatly increased in intensity.