Lamictal and brain

MAJOR loss of short-term memory and inability to concentrate.

I have been on Lamictal (for bipolar tendencies) for 3 or 4 years now. Overall it has been really great for me -- really calmed me and leveled me out like no other medication has.

Except that it has made me embarrassingly dumb. I have a graduate degree in electrical engineering, which is pretty worthless at this point because I cannot add two simple numbers in my head. My grammar and spelling skills have taken a nosedive. I took a grammar refresher class to try to boost it again, but I couldn't concentrate and can't remember what I learned. And even worse, sometimes I can't remember basic things like which way to flip the turn signal lever to signal left or right when I am driving.

I went up to 350 mg and it worked great (for the bipolar), but I could barely function at my job. So I've lowered it slowly to 150. My brain works a bit better, but still not well. Today in a meeting I was explaining something important and realized a couple minutes later that I was totally wrong -- I'd remembered incorrectly. So I had to interject later and explain that I'd been wrong. Things like this are very embarrassing and ruin my credibility at work.

But as I said the Lamictal has been amazing in other aspects. Ultimately I don't know if trading my brain for that is worth it, but for now it is because no other medication has worked. I worry though that even if I stop it in the future, my brain may not be able to recover, from lack of use.

Thank you all for your information. I am relieved to know I am not alone.

I've been on Lamictal for about 4 years (generic now), I did great on 200mg of the name brand but had to go to 300mg on the generic - but with the cost difference I was thrilled. I never had any issues with the generic vs the name brand, as I have read others have dealt with.

I am posting because I just talked to my Dr. today about the memory issue. For me it is the complete inability to memorize passages, verses, words to music, etc. In fact last summer I was working with a group of students, we committed to memorize a section of about 10 bible verses and I could not do it - I tried EVERYTHING, it was horrible and embarrassing! My Dr. said that it is a side effect that some people experience and when people go off the med, things get back to normal. Back to normal for me is being completely crazy, so abnormal is just fine! I have also noticed a difficulty recalling specific words when I am teaching, I have to search my brain for the word, which is annoying - it reminds me of President Bush.

That's it, YEAAAA for Lamictal - I'm also on 300mg Wellbutrin, this is the perfect combination for me! And easy to remember 300 mg of both = )

I have been on lamictal for about 7 months. I was not happy with the side effects I was experiencing (no sleep, bad motor skills, brain working slow) plus I was still having fits of rage and suicidal thoughts. I finally had enough and last week told my doctor that I wanted to get off to see if I felt any difference, because I pretty much felt the same on the 200mg than before I started. I'm slowly being weened off and now I am down to 100mg. So far I have not been getting up in the middle of the night as much and actually slept a total of 7 hours and only woke up once in the middle of the night for like 2 minutes versus the waking up every 1 to 2 hours and sometimes not being able to go back to sleep at all. My conversation ability has been returning and I'm not so nervous to talk and lose my train of thought or try to search for the right word. I've been dealing with a difficult situation in my life and I actually feel like I'm handling it better now than when I was on the full dosage . The only downside so far which is probably withdrawal is that I'm extra sleepy and I've been having to take 2 hour naps during the but I have a feeling that will go away. Besides my body might be making up for lost time from the 3-4 hours of sleep I was getting. I'm looking forward to being off of it soon.

"Bipolar cocktail" is an excellent way to articulate my medication regimen as well lol. I've been on Wellbutrin for about 8 years, and recently increased my dosage of Lamictal dramatically. (I'm on Lexapro too, but I don't think it's relevant to this situation.) Immediately after the increase in dosage, I started having greater difficulty with my cognitive abilities, a whole lot of trouble speaking (that pulling the word out of my head issue), short-term memory worsened beyond the little ability I had left from the rest of the side effects of my other medications, and other examples of brain mushiness :) Anyway, I recently brought this up to my doctor- she said these symptoms sound more like side-effects of Wellbutrin, and Lamictal is supposed to have few to none except a rash. But I haven't had a change in my Wellbutrin dosage in something like 5 years. Has anyone heard anything similar to this from their doctor? It doesn't make as much sense to me as it being a side-effect of Lamictal does...

"Bipolar cocktail" is an excellent way to articulate my medication regimen as well lol. I've been on Wellbutrin for about 8 years, and recently increased my dosage of Lamictal dramatically. (I'm on Lexapro too, but I don't think it's relevant to this situation.) Immediately after the increase in dosage, I started having greater difficulty with my cognitive abilities, a whole lot of trouble speaking (that pulling the word out of my head issue), short-term memory worsened beyond the little ability I had left from the rest of the side effects of my other medications, and other examples of brain mushiness :)

Anyway, I recently brought this up to my doctor- she said these symptoms sound more like side-effects of Wellbutrin, and Lamictal is supposed to have few to none except a rash. But I haven't had a change in my Wellbutrin dosage in something like 5 years. Has anyone heard anything similar to this from their doctor? It doesn't make as much sense to me as it being a side-effect of Lamictal does...

Yes I too have been noticing recent disabilities regarding brain function. Ive only been on lamictal for 5 mths and there has been remarkable improvement for its intentional purpose but I feel like such a dumbass.
I am a 4.0 student who is obsessed with A's and have been on the deans list for 3 yrs. However, recently I cant spell, take notes without immediately forgetting what my professor said, loose my point, or like just now, I completely forgot what I was trying to say. I have trouble speaking and finding the right words and its extremely difficult to think through anything because I loose what it is I was previously thinking! GGGRrrr.... Does that make any sense?

I am however seriously relieved to find I am not the only one having these issues and that its not mental regression or lack of intelligence.

Also, since being on Lamictal I have never experienced any skin problems, but 3 days ago I started tanning (which I know is already horrible for you) and today I have red blotches between my chest and on my back. These are places I normally burn a little bit when I start tanning again, but now there are welps and they burn and itch like crazy. Does anyone know if UV exposure causes this in Lamictal patients? Could it also possibly be a reaction to the tanning lotion?

Thanks
Itchy in Houston

I have been on Lamictal for Bipolar II for a little over two years now. The first side effect I really noticed was that I had zero desire to exercise anymore. I used to be pretty athletic, loved to go on hikes, now I could care less. Also, my brain is mush. I am a former honors/ Dean's list student; I had one professor in college tell me I was the only person in class who would ever be able to write professionally, and I have been trying to write the same novel for three years now. I forget how to spell words and how to formulate sentences. I can never find the right word. I forget what the plot is, what I wrote in the last chapter, so I am constantly re-reading what I wrote. I started to think that I had ADD because I couldn't focus on anything, and I couldn't remember if I had always been this way or not. Granted, I think I have always had a bit of a problem with executive functioning- organizing, prioritizing, completing tasks- but it has always been more of a problem with keeping my house clean, etc, NEVER with writing. Also, I have always been very good at remembering names, dates, events in history- the random sort of information that makes a person stellar at Trivial Pursuit- and all I can say now is, 'Uhhh... oh, man, I KNOW THIS.' Also, I am becoming incredibly antisocial, which I think probably has something to do with the fact that I no longer know how to talk. (A sidenote: I'd say chances are good that I have Asperger's; socializing has always been a challenge for me. My point here is that I'm wondering whether Lamictal is making the things I have problems with worse, ie, executive functioning, socialization..., etc. I used to be able to overcome these impairments intellectually; now that my brain doesn't function the way it used to, it's way harder to compensate.) I had a conversation with my husband the other day about all of it, whether he thought Lamictal was truly helping me. He told me that I no longer seem interested in doing anything anymore; that I am no longer sharp like I used to be; that I lack the vitality I used to have; that I no longer get excited about anything anymore. Now I know that Lamictal is a mood stabilizer, that I am on it to stabilize my moods, so obviously there are no longer going to be the highs that there once were. But now I feel so flat and dumb I just don't know. By the way, I have worked my way down to 75mg at night from 200mg. (Which is an improvement, I'll give you that- before I was scared to drive because I'd practically forget I was driving, that's how crappy my short term memory was.) Just so you know, I don't feel depressed, so it's not that my dose is too low and I'm experiencing depression. I just don't feel much of anything at all anymore.

Reading over some of these posts and wanted to share my experience w/Lamictal. Been on it over 2 year, 400mg/day. Sever bipolar with mixed & rapid cycling episodes. Oh YEA...I have side effects too: blurred vision that comes and goes, super klutziness, confusion, hard to complete sentences sometimes (just can't find the words sometimes for the simplest sentence!), dizziness, prone to broken blood vessels under the skin when bump into something or carry loaded grocery bag over my arm, jittery, short term memory loss, feeling really stupid like my brain isn't working sometimes. BUT...I will stay on this med because it rally works for me and the above effects are and bad, just frustrating. It took me a good 5-6 months for the meds to work as they should. Be aware that it won't make things perfect, mood swings and even moderate episodes can be expected. I am pretty much in a constant state of mild/moderate mania (2 hr sleep/night, hi energy, talk to fast, mind racing,etc), which is fine for me, as it really curbed the depression (maybe only 1 day every 2 months now and its NOT a BAD downer) I have found the drug is a good "stabilizer" keeping me mostly in a normal to moderate swing...never any severe swing. If the side effects are not unbearable, stick with the med, just be patient. It sure works for me. Learn to laugh at the klutziness and stupid moments and understand its the med and you. GOOD LUCK TO YOU ALL!

I've been on Lamictal for about 5 months now. I recently have had some horrible side effects. I've had the acne, brain fogginess and weight gain all along. About a month ago I was hospitalized for having a blood phosphorus level of 0.6 which is dangerously low. The symptoms around that day were nausea, feeling like I couldn't breathe, hyperventilation, heart rate of 120-130, tingling sensations from my nose to my toes, diarrhea and almost blacking out. Of course, the ER doc thought I was having a panic attack and told me to breathe into a bag and try to breathe slowly. NOT from a panic attack. Granted, I was panicking because I was scared. Has anyone experienced this low phosphorus problem?? I will be coming off of Lamictal in the next week. Hasn't made my depression, panic attacks or sex drive any better. thanks.

I have been on Lamictal for approximately 7 years. The product initially seemed to work a bit on controlling my seizure activity, and did provide a bit more confidence in social situations. At this point I was taking 400mg per day, and had little side effects other than the absent mindedness, and occasional problems with vertigo.
Briefly, about a year ago, I began having an increasing number of partial and general seizures, and was brought up to a dosage of 700mg per day. It was at this point that I began noticing what could only be called "hard-core" side effects. These included days where I was just totally confused, paranoid, suicidal, having an unrelenting feeling of not being able to breath, feeling bloated in my abdomen, and regularly being struck with a very irregular, very scary, rapid heart beat.
At this point, I am taking 600mg per day, and am still having most of these side-effects, but in decreased frequency. My neurologist never mentioned any of these possible symptoms, and doesn't seem overly concerned about any of the problems that I have mentioned in the past. With this in mind, it is somewhat relieving to see that there are others out there who are noticing similar effects.
If anyone can explain the difficulty breathing thing a bit more, it might help me wrap my brain (no pun intended) around this whole mess. I'm not sure if it's related to a decrease in blood pressure - I've been monitoring mine and haven't seen any irregularities. Or if it's related to a decrease in the amount of oxygen in the circulatory system due to the drug itself, or as a side-effect of the shallow breathing I have read about in other posts here.

I was on Lamictal for 4 years and after the first year I suddenly started having all kinds of teeth and gum problems for no discernible reason. But since Lamictal has the possible side effect of "sores or blisters on the inside of the mouth" I wondered if it could be related.

I did a Google search and am coming up with no experts yet, but lots and lots of posts connecting anticonvulsant meds, particularly Lamictal, Topamax, Neurontin, and Depakote, with dental problems. Dilantin is well known for causing gum disease and breaking down tooth enamel, loosening of teeth, and even breaking down of jawbone tissue.

I don't think the experts have connected the dots yet, but is anyone else having this problem?

lamictal controls seizures if you take it at the right time. i am on 200 at night and 200 in the morning plus epilim. sometimes i just sit and cry wen im trying to concentrate on reading books i have to study or trying to remember work i learnt at school which has left my brain. im failing school not matter how hard i try, i study all the time then the next day i have forgotten it. im so young and i havnt even started my future yet and i may have screwed it already. failing exams because i forgot wat i learnt the night before hurts so bad. its hard to say "hey everyone the reason i failed is because lamictal screws my memory" i know thats what it is. i was extremely intelligent before i started taking it, but now im a failure. i guess deep inside i know really im not a failure, but lamictal makes me one. : ( p.s add a constant hand tremor and sudden jerking movements every now and then.

I was diagnosed as being Bipolar a few days ago as Ive been on different types of anti depressants for years, I'm 23 now, and its NEVER helped me. The Doctor prescribed Seroquel and Lamictal. The Seroquel was supposed to be temporary until the Lamictal kicked in but after having HORRIBLE side effects from the Seroquel I quit it after only one night. Today was the first day of the Lamictal starter pack and besides feeling a little out of it and irregular heartbeat once in a while, thats all that I've noticed. But after reading all of your stories I really do not want to continue it. But the anti depressants don't help so I don't know what else to do. I'm not even sure that I am Bipolar. I do have self destructive habits like excessive shopping, stealing, partying etc. There are times when I'm ok and times where I am depressed but never to the point where I cant get out of bed. But I don't work or go to school. I quit all my jobs and I dropped out of school. I feel anxious a lot of the time, helpless, just really lost.....I dunno whats wrong with me. I wish I knew for sure because I would hate to continue the Lamictal and risk the more serious side effects for a disorder that I may not even have. I just wish someone could look into my brain and tell me for sure.

Hello! I've been taking Lamictal for about 6 years now. I'm diagnosed as BP II and have the most difficulty with depression. I currently take 500 mg-- 400 mg at night and 100 mg in the morning. I have to say that Lamictal has been very good to me for the most part. As long as I don't put myself into extremely stressful positions-- such as my last job-- I do quite well. I also take a combination of supplements with Lamictal which seem to give the extra push that I needed to completely get out of my last depression. I take 1000 mg EPA (fish oil), B-100 Complex, Folic Acid, Cal-Mag, multivitamin (high quality, organic), Vitamin D (at least 1000 mg) and a few others.

I notice that when I take it at night if I don't go to sleep right away, my mouth and tongue will tingle. Sometimes when I take it in the morning, I feel foggy and dizzy and sometimes get vertigo. Every now and then the side effects seem to get worse, which I am not sure about. I started searching on the internet because I've been noticing that the "tip of the tongue" problem has been occurring more and more often. I often cannot think of the word I want, simple things even. As others have mentioned, I also have difficulty with memory. I am still very successful, currently pursuing a 2nd Master's Degree, but have noticed that achieving the same level of quality of work takes a lot more effort than during my previous degrees.

I do have some periods of anger/irritability and have recently been sleeping a lot, though it probably has a lot more to do with the time of year-- winter with less light-- than anything else.

I am particularly worried about my memory loss and inability to sound "well-spoken" in a setting which demands that of me. It is frustrating! I don't want to do any lasting harm on my brain. After increasing to 500 mg from 400 mg, I have noticed more of these brain issues, but I'm also doing so much better mood wise!

I have experienced a lot of weight gain since I started taking Lamictal a year-and-a-half ago. I'm glad I hear others have experienced the same thing, as I thought it was just from what I was eating. I have gained over 40 pounds since I started taking the medication.

I also understand that Zoloft (which I take as well), alone or in combination with other meds, can can cause you to sweat a lot. I have been sweating way more than normal in the last year (since I started the Zoloft). I thought it was due to the weight gain, but apparently it's the meds.

Oh, the joys of brain medicine!

I have been taking Lamictal for just over a year. Some of the side effects have been noticable for a few months, but others seem to just be appearing and getting worse. I have loss of balance and coordination, my vision is gettng worse, I have a hard time concentrating and finding the right words, I forget how to spell common words, I have short-term memory loss and feel spacey. I can always figure it out, but it takes longer. I began doing Pilates every day about 3 months ago and still cannot get the routine down and it is just as hard for my muscles as it was in the beginning. I can't seem to lose weight and have horrible acne on my face. I had 2 seizures before beginning Lamictal and am suppose to be on it for 2 years before trying to go off. Without insurance though, I am unable to do follow-ups w/ my neurologist and she seems unconcerned and unsypathetic to my situation, not giving me the time of day. She never even told me all of these side effects could develop, much less that they might begin long after I started taking Lamictal. Has anyone had these side effects after having taken the Lamictal for so long then stopped taking the Lamictal? Will these side effects go away after I stop taking it??

I have been on Lamictal for about 5 months, I take 50mgfor bypolar disorder, my eyes see double, blury, and dry to the point they hurt. I go to bed with a head ack and weak with a head ack. I am afraid to drive because my brain does not work right. My legs all the way to my feet a swollen. I am mad at the world all the time. My husband children stay there ditance. I have turned in to a Bitch. I am wing my self of Limictal. Ihave never been this misrealbe before. I also Lithuim, and Tegratal I think I will do ok with out the head ack. Ronnie

Bi-polar II: recent diag. after years of chronic depression. on 25 mg for 1 week so far, just weaned off Effexor. Experiencing odd "brain pulses" and "white noise", irritability and ANGER, feeling persecuted. Could be mitigation of physical pain from acute bursitis flare. Hoping side effects will dissipate and I won't be such a bitch.

Due to a head injury,I am succeptable to seizures.I have been taking Lamictal for over a year. Initially I started with 300 mgs daily.It did not work effectively,so my doctor raised the dosage to 400 milligrams per day.I asked the doctor what are the side effects?He replied that tere are none. He said in fact "it stimulates the brain."I replied "how could any medication that deters seizures not have any side effects"??
At this point I am frequently constipatedI get rashes.I also am extremely forgetful terrible memory & cannot get my words out that I had no problem with while taking dilantin.I stopped dilantin, although it worked effectively, due it's terrible side effects& constantly having gum problems