Lamictal and irritability

I've been on 200 mg Lamictal for 2 months now, after 4 month titration up from 25mg; Going off Lithium 900mg titration to 450mg this week. Since 1st day of lower Lithium, all the common Lamictal symptoms went from mild to extreme. Whole body muscle aches (like 24 hours after a heavy weightlifting workout) worse in neck & back/shoulders/calves, bad headaches, swelling in hands & feet, extreme blurred vision, loss of memory, halted speech while trying to figure out what to say, fuzzy. I called the Clinic to simply ask which NSAID (aspirin? ibuprofen? Excedrin? naproxin?) to use to manage the pain. They all freaked and made me come in for a blood test to check Lithium levels. I explained I wasn't "overly" concerned about it at this point, but just looking for a recommendation, and that they may be over-reacting (even though I did appreciate their concern). I also reminded them that I had just **decreased** Lithium when it happened, so I wasn't having a Lithium Toxic attack (I'm well-versed in that, having been on Lithium for 7 years). It didn't do much good to tell them I thought their diagnosis was a little off. I'll find out the blood test results today, but I'm pretty sure I know what they'll be. They also wanted me to see my PCP since it could be something else. Again, the problem was a ramp-up of existing symptoms the next morning after I lowered Lithium (the only change), so I'm conviced everything centers around that. I think they're a little inexperienced with this med. (Lamictal/Lamotrigine) and if they'd just read this blog they'd probably learn a lot. They had never heard of the muscle ache side effect. Pretty hard to believe after reading all of your comments! My theory is that Lithium was somehow holding back the side-effects of Lamictal and now they're expressing themselves more fully. I haven't read anything like this on any internet discussion, so maybe my body is very different. But maybe my experience will give someone else some insight in a similar situation.
I might also mention something that happened to me I have only seen (kinda) in one other "blog" about follicle (sweat gland) cysts. Yeah, I definitely got the jawline acne starting at the Lamictal 50mg level & increasing at 100mg. But I also got my first ever "cyst" that concerned me and sent me to my dermatologist for the first time in 30 years (I'm 47 and saw the old guy when I had acne at 17!). It started as a blind pimple on my chest the week I increased Lamictal to 200mg (final dose), but didn't go away. It continued to grow (not diminish) over 4 weeks to 3/8 inch round/pink/solid/itchy/burn-when-rubbed. So off to the "Doctor" like my father used to do on a regular basis (I know I'm getting old now) and scalpel/pop/stitch it was out. But it was real, not my imagination or hypocondria, and the timing of its appearance was right when Lamictal changed to full steam. Since acne appears to be a common effect with so many, it seems it's not unreasonable that this occurs occasionally as well to others. Let me be the 2nd to mention it. No "official" verification, but....
I'm not bagging on Lamictal, and have been very hopeful that this would be better than Lithium. It has eliminated the GastroIntestinal problems I had on Lithium, but I am getting discouraged that it has all the brand new symptoms that are discussed in this blog. Your "stuff" is real. I wish the Docs/Nurses/Case Workers would spend 5 minutes checking your comments out. It might bring about a better informed conversation than the shiny Glaxo flyers provide. That is all.

Blurred vision, 15 lb weight gain, irritability, insomnia, excess hair growth (exacerbating my PCOS), nausea, nightmares, fuzzy thinking, bad memory, lose train of thought mid-sentence. Been on 100mg for 3 months. Doctor upped to 200mg but after 3 days on it and 3 days of no sleep, I dropped back down. Helps a bit with my depression, but I feel sort of numb. Not as bad as on some, but not good.

I have been taking Lamictal for about 2 months now. Started at 25mg and now at 150mg. I also take 10mg Lexapro and 1 mg of Ativan daily. I was diagnosed with bipolar-2 about 3 months ago. I'm not sure if this is the right combo for me. Most of my problem is with severe irritability followed by moderate anxiety and mild depression. I have never had a Manic episode just Hypomania which the doctor said is my anger and Irritability. I have been on every SSRI (anti-depressant) for the last 12 years, which does help the depression, but it increases the anger and irritability. Another Dr told me I am not bipolar-2, I just have GAD (generalized anxiety disorder). Not sure what to do anymore, the Lamictal is giving me bad headaches and dizziness and nausea. So now I take Meclizine for the those symptoms. Is there just one pill to help all these symptoms? Has anyone had any luck with Buspar??

This is a total nightmare and i need advice! I was on Lamictal for a year and about six months into my health began to slowly deteriorate. It started with shortness of breath and heart palpitations and eventually attacked every system of my body. My symptoms are muscle pain, spasms and knots to the point that i can't turn my neck sometimes, joint pain (mostly knees), stabbing floating pain everywhere, headaches, frightening tingling in my extremities and a few times my entire body, sore throat, flu-like feelings, stomach cramps, bloating and heartburn. The list goes on. I have been off of it now for two weeks. My psychiatrist has never seen this type of reaction before and is not convinced it is the Lamictal. I have been to every single type of doctor and the ER twice, had extensive lab work, CT scan and two MRIs. I have been off Lamictal now for two weeks and am not feeling much relief. I am so scared and frustrated and please need advice. Has anyone else experienced this? Does it ever go away? I feel like I am literally living a nightmare with no-one to turn to for advice because no-one seems to know ANYTHING!!!!

My son is diagnosed bipolar II mixed episodes. My son is on 1500 mg of Depakote, which the doctor increased as he was starting him on Lamictal. He also introduced and increased Seroquel. His personality is flat, his hands shake, he's gained 40 pounds and he sleeps after every dosing and naps in between. I was the one who suggested the Lamictal because I've read so many success stories about this drug. But I didn't realize that the doctor was planning to increase the Depakote. My son responds well to Depakote but it doesn't help in regard to his severe depressions or his irritability. Is there a way to sort out what is causing what?

Hello! I've been taking Lamictal for about 6 years now. I'm diagnosed as BP II and have the most difficulty with depression. I currently take 500 mg-- 400 mg at night and 100 mg in the morning. I have to say that Lamictal has been very good to me for the most part. As long as I don't put myself into extremely stressful positions-- such as my last job-- I do quite well. I also take a combination of supplements with Lamictal which seem to give the extra push that I needed to completely get out of my last depression. I take 1000 mg EPA (fish oil), B-100 Complex, Folic Acid, Cal-Mag, multivitamin (high quality, organic), Vitamin D (at least 1000 mg) and a few others.

I notice that when I take it at night if I don't go to sleep right away, my mouth and tongue will tingle. Sometimes when I take it in the morning, I feel foggy and dizzy and sometimes get vertigo. Every now and then the side effects seem to get worse, which I am not sure about. I started searching on the internet because I've been noticing that the "tip of the tongue" problem has been occurring more and more often. I often cannot think of the word I want, simple things even. As others have mentioned, I also have difficulty with memory. I am still very successful, currently pursuing a 2nd Master's Degree, but have noticed that achieving the same level of quality of work takes a lot more effort than during my previous degrees.

I do have some periods of anger/irritability and have recently been sleeping a lot, though it probably has a lot more to do with the time of year-- winter with less light-- than anything else.

I am particularly worried about my memory loss and inability to sound "well-spoken" in a setting which demands that of me. It is frustrating! I don't want to do any lasting harm on my brain. After increasing to 500 mg from 400 mg, I have noticed more of these brain issues, but I'm also doing so much better mood wise!

I take Lamictal with Wellbutrin 300 XL for bipolar with OCD tendencies. Some side effects are doubled due to this. Leg pain, especially my hips, forgetfulness (talk about annoying!), off balance and a bit clumsy, and some irritability. HOWEVER, my mood swings are almost non-existent. I still get sad/mad/depressed but it doesn't linger for days/weeks like it used to. I don't like the side effects and they do affect my quality of life but not nearly as much as my condition used to. I simply try to do things to make up for the side effects - stretching, taking things slower, forgiving myself when I forget things and not being afraid to tell people that I forgot something (tho IMO it isn't any of their business why).

I used to take Lamictal 150mg at night, no problems, but started feeling anxious in the afternoon/evening. My Dr. Rx'd 300mg lithium at night to see if it would help the anxiety, but I had very fitfil, unrestful sleep to the point where I was not sleeping much and very tired all day. So, the Dr. took me off lithium and substituted Tripletal 300mg in the evening. That worked, but I was still a little depressed & she increased my Lamictal to 200 mg at night. I started waking up after about 4 hours with horrible nightmares. I thought the nightmares were from Trileptal because that was a new med, but even after I discontinued it, I still get the nightmares/panic feeling that wakes me at night. I took 2mg Lunesta for a while to help me sleep, but then I slept too much 10-12 hrs. I take the Lamictal now in the morning & don't get those nightmares & I sleep fine now, but I feel anxious & dizzy and have trouble concentrating, again about 2-4 hours after I take it in the morning. Dr. says I can take ativan to help the anxiety, but I feel like I need to get off Lamictal and try something else. Maybe lithium will help if try to take it now witout the Lamictal.

Bi-polar II: recent diag. after years of chronic depression. on 25 mg for 1 week so far, just weaned off Effexor. Experiencing odd "brain pulses" and "white noise", irritability and ANGER, feeling persecuted. Could be mitigation of physical pain from acute bursitis flare. Hoping side effects will dissipate and I won't be such a bitch.