Lipitor and lef org

I had 95% occlusion of the major artery in my heart July 2007 with no symptoms except slight shoulder pain on 3 occasions. They did a cath and inserted 2 stents. Started with Lipitor 10 mg. and my LDL dropped from 75 to 112. The MD wanted to double the dose, but I refused because of intermittent nocturnal nausea. MD switched me to another statin and I had immediate muscle involvement and severe nausea at night. She wanted me to try another statin drug and I refused. After a 2 month period of no statins, she put me back on Lipitor 10 mg. daily. I decided to cut the pill in half and take it twice a week, then move to every other day and gradually go to 10 mg. daily. Immediately, the nocturnal nausea started again. Last night I awoke at 2 a.m. with nausea, sweating, sore muscles around my rib cage. Still no sleep at 4:30 a.m., so I got up and tried to eat something. This has been the pattern every night since I went on Lipitor.

I don't know if I can take this any more.

CK

I am a 35 yr old male and have been taking lipitor about 7 yrs. I have a genetically high cholesterol and it has been up to 275. On lipitor its around 175. Over the years I have been on this drug I went from being a normal weight and active to pretty much lethargic and sedentary due to lack of energy and gained ~50 lbs. I couldn't sleep. I got random nausea and fogginess in my brain to the point I could not remember how to perform my job. I usually had minor aches and was bloated. the past year everything has gotten much worse. For a year now, I have been getting large rashes on my body that itch severely and no medications have worked to alleviate them. I found out recently from my doctor that I have a genetic marker in my cholesterol that makes me 3 times as likely to have a heart attack. Its a portion of the cholesterol, i think its called LDL-b or something like that. Anyways, My doctor prescribed zetia to help with my cholesterol since the lipitor wasn't doing it alon. I begin feeling very sick when taking the zetia and after a week or two stopped it. The problems didn't end. As long as I remained on the lipitor, the problems seemed to continue. Its like the zetia released a dam of problems. I stopped the lipitor 4 days ago and have noticed that I feel energy coming back to me and the rash is starting to go away, but I ache severely all over. My shoulders, forearms, and legs are so sore and painful that I can't do anything about this except sleep so I don't feel the pain. I am also very weak feeling and I notice stiffness in my fingers and my grip is very weak compared to how it normally is. I have nausea and stomach cramps and constipation. I feel miserable. I notice its worse in the morning and gets a little better towards the afternoon. I typically took my lipitor in the morning. I do not know if there is a relationship here. Please advise on any help you can provide.

KMJ
07-30-08

I would encourage every patient on statins to read the recent article (Feb. 2008) by Dr. Peter Langsjoen, MD/Cardiologist: http://www.lef.org/magazine/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm

The following information from this article is pertinent to complaints of muscle pain/weakness and fatigue:

"All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. This has nothing to do with diastolic blood pressure, but rather represents impairment in the relaxing or filling phase of the cardiac cycle. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. Thus, if diastolic dysfunction is severe, it can result in congestive heart failure. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10."

I hope this information will be of help to patients suffering adverse reactions from statins..

I am a male of 67 years old. I took Lipitor for a year, and after a few months of taking it, I felt muscle pains in my arms and shoulders, as well as my back. I felt weak and could hardly put my socks on by myself. I told my family doctor that I thought the problem was caused by LIpitor. He said it couldn't be possible, but he couldn't figure out what was wrong, so he sent me to a rheumatologist, who gave me an initial diagnosis of polymyalgia rheumatica. I went back for a checkup, and although the sed rate was normal, the C-reactive protein was elevated. He felt his diagnosis was an accurate one. He prescribed prednisone for me. I had some doubts about it, since I am diabetic, and was concerned about the elevated blood sugar it might cause. Well, it did elevate my blood sugar, and I weaned myself off it within three months. My blood sugar went back to normal, and while the prednisone helped the symptoms of muscle pain and aches, after I stopped it, the pain returned with a vengeance.

About a year passed after discontinuing the prednisone, and I felt worse and worse. Any time I engaged in physical activity, such as yard work, I was almost incapacitated for two or three days. I felt weaker and weaker, and by now, my activity is about ten per cent of what it was three or four years ago. I am unable to do anything physical without paying a heavy price.

I would tell the doctor that I felt the problem was caused by the Lipitor. He would dismiss my comments, saying that the pain should have gone away after discontinuing Lipitor. He sent me back to the rheumatologist with results of recent blood tests. Both the sed rate and C-reactive protein were normal. The rheumatologist touched my back and other areas, which caused me to jump. He said it might be fibromyalgia. I told him again that I thought it was caused by the Lipitor. He said the same thing my GP had said: if it had been the Lipitor, the pain would have gone away when I stopped taking it. I know the Lipitor caused the pain, because I tried red yeast rice for a couple months. The pain increased to almost unbearable, so I discontinued the red yeast rice. If I were not susceptible to the pain from the Lipitor, would the red yeast rice have increased the pain?

So here I am with a fuzzy diagnosis from the rheumatologist, and no clue from my family doctor (that he will verbalize, at any rate). My life has gone steadily downhill. I used to be a strong, active person, but now I can do very little, and my strength is a shadow of what it formerly was. What can I do?