Lipitor and muscle pain

I'm a 47 year old male, with no medical problems except high colersterol. I took lipitor for a few months. After the first month, I noticed the general weekness in my legs and stiffining of my achilies tendon. By the third month, these problems continued to worsen. My achilies tendon would be so tight, I had to stretch my foot for a few minutes before getting up in the morning. Then, after getting up, I'd walk like Frankinstein for awhile. My achillies tendon was sore all day, and my legs were weak. My legs felt like there wasn't any blood or strenght in them; I felt like an old man who's leg were atrophing.

Anyway, I was playing tennis one night, and a friend noticed I wasn't moving. My wife remarked that I was on Lipitor, and we think it's hurting my legs. This friend knew of several people, including his father, that had experience the exact same problem. I quit taking Lipitor that very day. Since then, I've talked with others, and many have had this same side affect.

Please note, two guys in my office are taking Lipitor with no problem, so, it not universal. However, I believe it more common that the medical establishment is reveling. From what I've briefly read, Lipitor block the production cholesterol, but also blocks the production of CoQ10, dolichols and other vital liver biochemicals needed for healthy muscels and tendons.

I've been off Lipitor for a couple months, and my legs and achilies tendon are good. Not a 100%, but good. I still experience moderate stiffness in my achilies tendon the morning after playing tennis and very stight stiffness otherwise. During the day, my achilies tendon feels fairly normal, and my leg strengh feels normal.

I'm not a hypochondriac; however, I have no doubt, this drug is dangerous and causes muscle and tendon stiffness and damage.

I have been on Lipitor for a year. I could walk ten miles without leg Fatigue before lipitor but walking a mile is killing me I know it is the lipitor I cant find a doctor who admits this plus I am limited to Medicare doctors only. Is there a doctor that can advise me how to stop the use so I can walk my miles which should be better for my heart? I can change my diet.

I am 39 years old and work for an interventional cardiology medical device company in Tokyo, and so know the importance of controling one's cholesterol, keeping the LDL's low and the HDL's high. About two years ago, my doctor put me on 10 mg of Lipitor. Several months later I herniated a disc in my neck between C6&C7. From that point onward, I attributed all of my neck and back pain, and newly acquired total body muscle and joint pain, to the herniated disc, it made the most sense. Over the last seven months, I have really worked on my diet and began to exercise more (even though quite painful) and was able to lower my cholesterol. This resulted in my doctor lowering my Lipitor prescription from 10 mg to 5 mg. I noticed a slight alleviation of the pain I felt in my hip joints and calves. About two weeks ago I took myself off Lipitor completely and found further improvements in my total body muscle and joint pain. It's still there but greatly improved. In retrospect, I now believe the Lipitor may have been the culprit (or at least a contributing factor) to my herniated disc due to muscle degeneration in the neck, and all of the subsequent muscle pain, especially in my hips and calves. I fully understand I am not going to die from calf-pain, but may from heart disease. However, I have found my quality of life has improved tremendously over the last few weeks. Less irritability, better sleep, less pain, clearer head. I feel like I have lost two years of my life on Lipitor via personal suffering and lack of ability to do much of anything with my wife and two young daughters. We all need to take charge of our own health and therefore I encourage anyone who feels completely different after taking Lipitor to engage your physician, and make sure its the right option for you. If damage has been done to my musculature I hope I can reverse it. It is evident to me that some serious clinical studies should be done to investigate Lipitor's effect on muscle degradation and hope others will consider carefully whether or not do go on this drug. If you do, monitor yourself closely.

The Health & disability commissioner in NZ has received my complaint of criminal negligence re my former doctor. They have now asked my former doctor for a please explain his version of events. The police have written to me saying they are seeking medical advice re criminal/negligence/failing to carry out professional duties complaint. Whilst I agree with everyone's feelings on big pharma, it is my very firm opinion that the doctor is the "retailer" and it is the doctor's direct responsibility to us the customer/patient to monitor and inform us of all safety concerns. Big pharma in covering their butts have warned the doctors to warn the patients. Of the 8 doctors including an anesthetist I have spoken with socially and in consultation, not a single doctor could name any adverse effects with statins beyond mild muscle pain. Given the warnings from pharma on the labels that is wholly shameful & negligent. An effective way to help others avoid being maimed like us, is to fight back from the bottom. The FDA and CARM in NZ take no notice, litigation is expensive and drawn out so neither really helps future innocent victims. I encourage everyone where negligence is fairly on the table to take your complaints to your country's police and medical discipline bodies enough of these complaints will soon have the doctor's "reading & obeying instructions" which would go a long way to preventing more tragic victims.

I have used Lipitor and/or other satins for many years. I had to get off a generic a year ago and went back to Lipitor. I believe it caused my tinnitus and muscle and nerve issues all over my body. I recently stopped taking it and now 4 weeks later I am getting some relief. I did find something that has really lowered my triglycerides and my cholesterol. It is a brand new diet supplement that contains a new source of omega 3 and antioxidants. contact me and I will give more info on this wonderful all natural wellness product. It really helped me.

CRIMINAL NEGLIGENCE COMPLAINT FILED. I copped the worse of everything and almost croaked with statins. 20 months since stopping the poison, I'm still not right but vastly improved. Medsafe in New Zealand twice posted to prescribes ".. . . warn the patient of muscle pain and if muscle pain or weakness occurs cease the medicine immediately ... "they also warned prescribes "20% of adverse reactions being reported included mental disorder including violence and anger .... "Apart from all my pain, I suffered severe mental disorder and violence to others. I repeatedly presented painful muscle cramps to the doctor, who repeatedly told me age, arthritis, salt in diet etc. I went to my doctor frightened at the nasty way I was treating my wife of 30+ years, telling him it was so bad one of us was going to have to move out until the problem was sorted. he was sympathetic and told me none of his patients had said this to him before, probably true, but Medsafe had. Today in writing I hand delivered a written complaint of criminal negligence to our police and the New Zealand medical council, the doctor ignored clear written instructions putting my life at risk and those around me with my violence and dangerous driving, heres hoping others may be saved. There is a new report out from JACC journal of American cardiology stating the wonderful strengthing and healing power of fish oil, google it. We personally know of about 20 customers, friends and family who have been poisoned, a couple have indicated they will consider following and laying criminal negligence charges.Saturday afternoons are visiting days for prisons in New Zealand if the after hours doctors are closed. I'll post when I hear from the police. This very dangerous practice has to be stopped for the sake of humanity.

Cholesterol slightly elevated Dr. recommended 10mg dosage. Began experiencing neck and shoulder pain, dizziness, nausea, foot stiffness and leg numbness up to the lower thigh. Voluntarily stopped the medication after four months. All noticed side effects disappeared except for the foot stiffness and leg numbness. It has been 2 1/2 years and these remaining side effects are constant. Not optimistic for recovery. Anyone else with similar symptoms?

I've been on lipitor and other generic forms of it for the last 8 years since the age of 26. I started on 10mg then 20mg and later 40mg. About 4 years ago I started with severe stomach cramps. The pain is so bad that I have to go home in the middle of the day, I can't walk or sit straight the pain is that bad and NOTHING helps. On a scale of 1 to 10 I would probably put this at a 7 or 8. I would also be nauseous and be really tired. I have had countless opinions and tests done and doctors keep telling me it is an "enigma" and there's nothing wrong with me. We've treated it through coeliac diet, exercise, lots of water, but it never helped. About a week ago I stopped drinking my meds by pure chance. I have not had one incidence of stomach ache. My doctor tells me that it's not possible for the lipitor to be the cause. I am sure he's wrong. Has anyone had a similar experience?

Was on Lipitor 2 years ago and had to come off because of side effects - sever muscle pain.. Prescribed Niaspan instead .. 2 months ago my cholesterol rose to 7.1 and my doc put me straight back on Lipitor - 10mg.. Feeling lousy - neck pain, leg pain, dizziness, fatigue ... head feels fuzzy all the time and get sudden twinges in my chest.. Had stress test done last week and all ok.. Also have severe digestive problems. Going to wait until 2 full months done and going to get bloods done again

I have been taking 40mg lipitor for over 9 years now.

I have had back issues since an injury to one disc (L4?), and had microdiscectomy in 2001? Took about two years to actually get close to normal.

The last few years, I have had multiple issues with shoulder pain, wrist pain, elbow pain, lower back pain, Upper rump muscle pain , and now both hips are killing me (the shoulder, upper rump muscles and hips are by far the worst). And I am now so weak in my lower back muscles, that it feels like I will (and do) pull out my back.

I have seen NO many doctors I can't even name them all. I have had operations, multiple injections (cortisone) taken pain meds, etc. Nothing has helped and in the last year and a half, I have gotten steadily worse. To the point where I can't really do much of any activity. Sleeping at night is painful. Can't lie on left shoulder, and can't lie on either hip for more than a few minutes. If I fall asleep on my side, the pain wakes me up. When I try to walk, 80% of the time, I end up with a pain in my upper right rump (sacroiliac area), that I MUST sit down to get the intense pain to go away, which it does. But comes right back when I walk again.

I have had x-rays, MRIs etc, and never reveals all that much. Disc issues, yes. NOt much else.

Recently, I have begun to get a nasty clicking (catching) on my left jaw (joint?). Not really painful, but something definitely wrong. My dentist sent me to his Chiro. I went and liked him right away. I had gone to another chiro for years and I believe in them. But this one is the best I have seen.

Anyway, one of the FIRST things he suggested, was that it was POSSIBLE that the Lipitor is causing all of my problems. Put me on COQ10, and doing multiple adjustments and treatments. I will be seeing my regular doctor 5/26, and my chiro wants me to see if he will take me off lipitor and put me on Niaspan instead.

I guess my question is: Can Lipitor be fine with me for so long, and then in such a short period of time, turn me into a compete wreck from the pain and wasting away of my body/muscles? I've told doctors for over a year now that there is SOME connection as to all these issues and pain. One Doctor, of course, gave me the "you are getting old" bull. Yes, I am 56 yrs old. But I understand the process of getting old, vs the complete failing of ones body.

Also, IF it is the Lipitor, can it possible all go away? Or should I expect some damage forever?

One more thing, the last ortho I went to the other day for a second opinion, wants me to do a EMG, to see if there is muscle damage. I was not planning on doing it, but wonder now, should I? He was not doing it because of lipitor, as he never even talked about that to me. I had shoulder operation and have not had the results I feel I should have had.

My mother, who is in her early 70's, is diabetic and had high cholesterol. She had been taking Lipitor and the doctor increased her dosage. She was experiencing muscle pain for some time, especially when she woke in the morning. The muscle pain worsened and her muscles became very weak. She had been complaining to her doctor for some time. It took a chiropractor to suggest it was the Lipitor. Her doctor finally ordered blood work and her enzyme levels were at 9500. She was immediately hospitalized, tests run and IV's given to flush the Lipitor from her system. She was expected to slowly recover. After weeks, her levels dropped to 6500 then began to rise. Her doctor now says her muscle damage is permanent and plans to give her prednisone to stop the inflammation. This muscle damage is a terrible "side effect" for a drug that was supposed to help her. She can hardly get up or down from a sitting or lying position, can hardly walk and her lifestyle has been severely curtailed. She is also exhausted all the time.

I was put on Lipitor 10mg 2 weeks ago after my bloodwork from my yearly physical came back that my cholesterol went up again. Levels are HDL 61 LDL 176. After the first week I called my MD to advise that I was having chest pain and muscle pain in my legs and forearm. He said to cut the dose in half which I did last Thursday. Yesterday all of a sudden I had heart flutters the entire day! I am a 43 female who goes to the gym 3 times a week doing 30 minutes of cardio and weights. I eat right and overall I am in great shape except having high cholesterol. My blood pressure is great, had a stress test and echo last year both negative for any problems. I called my doctor today and advise that I was still having fluttering in my chest and that I am stopping the Lipitor. What good is being on a medicine that helps with one problem but then causes others that you may need more medication for???
I have been feeling like crap ever since being put on Lipitor and I believe that it is the medication that is giving me the problems. Last year my MD put me on Zocor and I stopped that after having the muscle pains. I am now hoping that things will get back to normal and I plan on telling my doctor that these "statin' medicines are not for me and there has to be something else.

777
I've been noticing that you as well as bobby are continuously replying to many of the posting. I stopped taking lipitor in December after having chest pains for 10 months which included being hospitalized for 2 days of testing. I'm still having the chest pain although I believe it's getting better. There was a week in the beginning of this month that I had no pain at all but now it's back. My question to you and bobby is you keep saying you still have some side affects for months but fail to list them. What are they and with your experience, why does Lipitor cause chest pain? What have you found out in your research? Is this drug causing damage to the interior lining of the arteries? Is this why many people are getting the pains from?

My dr. put me on Lipitor. I took it for 4 months. At the 4 month mark, I was SO depressed, I couldn't function. Crying constantly, no concentration..almost like I was in a trance most of the time. I had problems finding the correct words to use, was paranoid about everything and everyone. I actually thought I must be in the early stages of Alzheimer. Honestly..I didn't know what was wrong with me. I had an actual "pain" in my heart and pins and needles feelings in my fingers and hand on the right side. My forearm became terribly "achy". I went back to the dr. and she said.."oh, I think you're depressed!" Gave me a prescription for celexa (anti-depressant, and sent me on my way. I went home..decided that I WAS NOT going to take an anti-depressant and began to do a little research on the lipitor. Amazingly..I couldn't believe the info that I found with people who had the same symptoms as me! I stopped taking it immediately and within 2 days..my depression and paranoia went away. However I am left with such weakness and pain in my rt. forearm and bicep as well as both shoulders. I went back to the dr. and explained what I had done (guess I shouldn't have mentioned about what i had read on the internet) Because she wouldn't believe that the lipitor would cause that and also said that I had been off of it long enough now(4 months at that point), that any pain that i was experiencing would be all gone! She wouldn't believe me and made me feel like I was crazy!! So..now not sure what to do. Will the pain go away, I wonder? Is there a way to "detoxify" one's self to rid us of all the bad stuff or is the muscle damage permanent and does it keep on going and just keep destroying the muscles, even though we've stopped taking the stupid stuff?? I wish someone could come up with an answer, because I don't know who to go to ask. I can't believe how weak my arms have become since taking it. Will it ever improve I wonder?

January 26, 2009
I stopped taking 20mg of Lipitor for the following reasons: arm and muscle pain, wrist pain, neck and shoulder pain, knee pain, foot pain, arm weakness when raising my arms, mental fuzziness. I
Withdrawal symptoms : headache, eye ache, increased neck pain.
My goal is to see if the dosage symptoms decrease within two weeks and maybe I will try 10mg of Lipitor and see if that amount produces the same symptoms. My doctor directed me to a Rheumatologist as recent blood work showed inflammation in the arthritis panel. I am waiting to see if being off Lipitor for two weeks might reduce my arthritis symptoms .
I had a stint put in March 2008 and I am on Plavix (75mg), Lisinopril (10mg) and Lipitor (20mg).

I am a male 45 years and used simivastin another statin for three and a half years. Over this time i had severe muscle pain at time then about 4 months ago the muscle pain in my legs came on with a vengeance. It started in both thighs then calfs got very tight sore ankles feet and eventually got in to my arms. A deep achey sort of a pain and an irritability that casesa feeling like a toxin in my inside elbows that makes me want to stretch all the time. I feel very weak compared to my former self. I tried many things to alleviate the pain but nothing really took the pain away or even decreased it much. sometimes i would lay and groan in agony. I especially noticed that draghts and weather changes made me feel worse????. I stopped taking the simivastin 6 weeks ago. I have not had a lot of improvement but must admit thet i have been trying to push my self over this and probably done more damage. My ck levels are normal but my liver enzyme is increased a little. I started also to take q10 and L- carnitine along with magnesium. I might be improving a little each day but nothing definite. I saw a rheumatologist who has no diagnosis and isn't to committal on whether the statin is to blame. He put me on celebrex which has finally given me some relief. Can anyone relate to the worsening of symptoms with cooler changes in weather? and is there anything else i could do to hasten recovery? Thank you to all contributors on this board although it is the first time i have contributed this board has been a scores of help to me.

I started taking Lipitor in 2004 and by 2008 was taking 40mg daily. I'm not sure exactly when certain symptoms manifested themselves, as looking back they now seem insidious, but I do know they became bad enough in 2008 I went off the drug myself, especially after reading postings like those at this website. After being off the drug for a month, it was clear to me the most of the symptoms dissipated, but it did have a residual affect. I realized I had suffered a loss of range of motion (ROM) in my left arm (frozen shoulder) and have been in physical therapy for over a month to restored 80% of it. I could not have done this while staying on Lipitor as I was experiencing “deep” muscle pain and weakness. I still have some weakness and pain in my left arm and shoulder and don’t know if it is permanent.

I am Hypothyroid and take Synthroid and am currently going through menopause and am on partial HRT. I took no other meds other than the Lipitor. At one point, I thought my symptoms were stress related, but realized my symptoms were causing the stress. Aside from the muscle pain, spasms, tingling and numbness experienced in my left extremities, I experienced gastro intestinal disturbances, occasional vertigo, some lower back problems and other aching in other extremities (like that of flu symptoms). I also suffered recurrent mental fogs, which I initially attributed to some lack of regular exercise (although I lead a relatively an active life), but that was not the case, as even after aerobic activity the tingling and pain would resume.

When I told my physician I had stopped taking the Lipitor (at that time for nearly a month), he didn't blink an eye. I agree with previous blog; the idea of statins are to lengthen your life, but what kind of life is it when you are in misery and nothing short of ceasing the medication brings relief?

I'm not advocating everyone "doctor themselves. Listen to your physician, but most importantly listen to your body and trust your instincts when it comes to these types of medications. Symptoms listed about scripts described as "rare" are usually not that rare at all. You are not crazy.

I took Lipitor for about 6 months. Right after I began taking it, my legs, especially my right leg began hurting. I got off the drug at 6 months because my legs hurt so badly I could not sleep at night. I just had X-rays of my right knee done, and I have almost no cartridge left on my right knee cap. I now may have to have knee replacement therapy. My doctor that put me on the lipitor said that it was not the lipitor that caused. I think it is very odd the pain began when I started the drug.

Hello I'm a 41 year old female, and I took Lipitor 20 mgs for 6 months about two years ago. When I called my doctor's office to complain about side effects they told me it couldn't be the Lipitor because I had been taking it for a month already, and would have had problems before that. I eventually took myself off of the drug 5 months later. Here are some of the side effects I experienced:
Itchy fingertips, increased blood pressure, 30lb weight gain, shaky hand writing, acne, poor driving skills, poor memory, hair loss, "frozen joints", IBS, incontinence, low grade fever, itchy feet, numb toes, numb hands, foggy brain, joint pain, muscle pain, foot pain, plantar pain, dizzy, jaw pain, back and neck pain, week ankles and wrists, nasal allergies, skin rashes, migraines, heartburn, Increase in Astham, heart palpitations, knee pain, difficulty standing up from sitting position, difficulty climbing stairs, water retention alternating in feet, hands, arms and legs, almost constant taste of bile in my mouth.
These are only the ones I can remember. Two years down the road everything but the muscle and joint pain and weakness is gone. even those have improved a lot. I stopped taking the Lipitor and lost all 30lbs I had gained on it, without dieting, in a months time. I still have two toes on each foot that are partially numb. I have trouble climbing stairs, and getting up from a sitting position. I can do both, but I move slowly while doing them. The pain in my muscles and joints drives me crazy, but I'm grateful that the rest of the symptoms have cleared up. My doctor never believed me about my symptoms, and neither does my new doctor really. Went to the emergency room for asthma that was not responding to my inhaler, and they were about to let me go home when I mentioned to the doctor that I had been on Lipitor. Suddenly a huge battery of tests were ordered including a CT scan and a stress test. When I asked the doctor why he said that they just wanted to be sure that it wasn't something other than asthma. Why did they do that after hearing about the Lipitor? Do they know something? Are there doctors who believe that statins are killing and seriously injuring people? I'm so angry. Even as I sit here typing I know when I stand up I will have massive amounts of pain that I will have to "walk off". My quadriceps have not recovered, and remain ridiculously weak.
If I can stop one other person from going through this I will be happy. Thanks everyone for taking the time to list your symptoms. It makes me feel better to know that someone believes me, and knows what I am going through.

I've been on 10 mg of Lipitor for approx 2yrs. A few months back I began experiencing severe constant right hip pain. A could walk through it, but had many sleepless nights due to the unrelenting deep pain. I had difficulty lifting my right leg without support from my arms. I'm 54 and otherwise in pretty good health. I stopped taking the Lipitor about 2 weeks ago and while I still have some pain it has decreased about 75%. I can sleep at night and am even pain free some of the time. If anyone has had a similar experience would appreciate knowing and if the pain eventually subsides and any suggestions to support the healing process.

I am a 62 yr. old female and in good health. In January 2007, my doctor ordered a cholesterol test and the results indicated a number of 237..."bad" cholesterol was not horrible, "good" cholesterol was very good. The doctor put me on 20mg of Lipitor without any hesitation... After a week or so, I started having horrible leg and muscle pain, so when I went back in 3 months (cholesterol 181), I told him I couldn't take this med, so he put me on Zocor. Really bad joint pain with this one, so I went back again in 3 months(cholesterol about the same) and told him again that this one had similar side effects and diarrhea. He then put me on Crestor...took this med, but was so lethargic and in a fog, my family told me to get off of that one. Went BACK to the Dr. in 3 mos., told him I couldn't take this one...he put me on prescription strength fish oil (6 per day) saying that this one should not have side effects. Other than some gastric/intestinal rumblings and some diarrhea, it was ok, but when I had my cholesterol checked it had gone up HIGHER than when I started this whole ordeal, so he put me on Welchol...saying that this one was not absorbed in the blood...blah,blah, blah... Still had the gastic/intestinal issues, SO when I went back 3 mos. later in March 2008 (cholesterol 200)and having already stopped this one myself, I told him I was NOT going to take any more meds for this "issue," and I would manage it with diet and exercise. I told him that this was supposed to be the best time in my life, and I was tired of feeling so poorly. He blatantly told me that if I did stop taking the cholesterol "you'll probably have 10 good years and 10 "crappy" years, and he was visibly angry about MY personal health decision. I had at one point during that the 1 year + mentioned to him about the information that I had been reading online...he pooh-poohed the whole "internet" thing, indicating that he had better information (I"M THE DOCTOR" syndrome!). Needless to say, I don't trust him, BIG PHARMA, or anyone else who says that these statin drugs are NOT harmful...My husband has since stopped taking Lipitor, due to our children and me noticing lapses in his memory. These drug companies and doctors are totally ignoring the side effects and health issues of the unsuspecting public. Hopefully, the truth will emerge, but how long it takes...who knows??????? I am glad I'm not on them anymore...I feel GOOD, and I know that whatever aches and pains I have ARE from aging and not drugs!!

Hi, I am a 45 year old male with high cholesterol. prescribed 20mg. of Lipitor to control it. Am having a strange twitching muscle in my right calf since I started the meds. Forearms hurt, trouble sleeping, twitching in my sleep, apparently, tiredness. I'm worried about going off it. My dad died of a heart attack. Would it hurt to try going off it for about 3 months?

I posted several months ago on this string and wanted to update. I had bloodwork done for the 1st time since I quit the 20mg of Lipitor in August. LDL went from 123 to 210. Total Chol went from 191 to 285. HOWEVER all shooting pains I had been experiencing in legs, feet, and chst are GONE! Went back to my Dr. today, told her that same result and my serious objection to taking any kind of statin and she prescribed CRESTOR while telling me it was more potent than Lipitor! WTF!!!

I refuse this course, am drinking 30 - 40 ozs. of water each day now like I should have been, doubled my CoQ10 to 200mg/day, finally getting back into the gym to lose weight and get the HDL up from the level of 36 it is now. also started to drink the new yogurt type "shot" of Promise for cholesterol that provides 2 grams of plant sterols per day.

I will not take statins ever. I WILL find a natural way to keep my Chol under control. I've also been convinced that you don't have to be at or under the 200mlg of total chol to be healthy. Look at your C Reactive Protein and Homosiytes (sp?) If they are in range you should be good.

I know Lipitor was the cause of my rupturing each of my Achiller tendons a year apart while playing tennis in my late 40's Muscle pain soon followed.

I am wondering if the plantar foot pain that my husband is suffering for 6 months could be from lipitor that he is taking for several years now. Has anyone have this problem?

I have been on 20 mg Lipitor for years, and as I also have Rheumatoid Arthritis, all my symptoms have been blamed on that. I have been diagnosed with Fibromyalgia and put on Lyrica because of the muscle aches and depression. My lower back, hurt in a car accident when I was 17 years old, had gotten so much worse that I had 12 steroid shots in my lower spine a couple of years ago. They didn't help my back at all, but my blood sugar went from normal to diabetic levels, and I am now on Byetta to try to lower it.
I am a 56 year old woman who was the math specialist in a school district until last December when I had to retire early. My back pain was so severe that I could no longer go from school to school carting materials. I could barely make it from the parking lot to my office. Mentally I was not ready to retire, but physically, I was (and am) a wreck. I have severe muscle pain in my shoulders, sometimes one or the other, but always present. I have tingling in my right hand, especially in my fingertips, and have trouble gripping and drop things easily. In the last few months the pain in my right thigh and calf has gotten unbearable. I thought at first it was sciatica, but I have had sciatica before, and this isn't the same, although there is tingling, burning , but the pins and needles is so deep in the muscles I have just sat and cried, or wanted to scream. I have wished I could just cut my leg off. And...I am on some pretty heavy duty pain killers for the RA: a small dose of prednisone plus Enbrel, Methotrexate, and Vicodin, and this pain is cutting right through all these meds. I get severe headaches, I went off Lipitor for 5 days and seemed a little better, but then went back on, and it came back.
Since I no longer work, I sleep longer, am exhausted ALL the time, have terrible mental fog, am clumsy, cannot stand for more than a minute or so without wanting to scream, cannot walk more than a few yards...just getting to the car is an ordeal. I tell people that I can only shop in shoe stores and furniture stores...the only stores with places to sit down.
I no longer cook or clean, cannot play with my granddaughter, even holding a book to read can be too much, and I love reading. I feel I am just dying bit by bit as I lose parts of myself.
My doctor is really into lowering cholesterol, and has put me on Zetia in the past few months...and it has been in this time that the pain in my leg has gotten unbearable. He wants my cholesterol to be between 50-60, and has said that the Zetia along with the Lipitor will do that. Is this normal or in any way reasonable??? I am having a full blood workup done tomorrow morning, and I want to go off the Lipitor starting the day after.
I came across this web site tonight while looking up Lipitor side effects, and I am shocked. I have so many of these symptoms, and there are so many I had no knowledge of at all. I knew about the muscle aches, but that's all. I hope someone can help me with what supplements and vitamins I should be taking. I started taking CoQ10 a month or so ago. What else should I be taking for my health? I know vitamin C and fish oil, but don't know how much or anything else. Right now I am just stunned with the thought that all of these problems that have left me unhappily retired, exhausted and in constant pain can all be caused from a drug I have been taking to help me be healthier.

Eight years ago I started with 10 mg. Lipitor and took it without problems for about five years. Doctor wanted me to change to Crestor and within four months I could hardly walk, shuffled my feet and had pain in muscles. Switched back to Lipitor two years ago and this week began to experience muscle pain so I stopped taking it three days ago. Any time I am in a prone position, or sitting, the leg pain is incredible. Walking there is minimal discomfort. Tried a massage today to no avail. Any way to alleviate this withdrawal reaction, if not, when might it dissipate?
J. in Pain

Boy, after reading all the negative testimonials on Lipitor, I will throw mine in the garbage. That is what they are meant for. I have severe headache, and muscle pain, and foggy head, and I have only been on the crap for 2 months. I believe a lot of people's health is being ruined, and a lot of deaths are happening as well because of Lipitor and other statins. Mark my word, one day this drug will be withdrawn from the market, and the poor Pharmacutial companies will be in huge trouble.. They have the world convinced that we all need statins to bring cholesterol down.. The era when my parents lived , and lived long lives, and on farms, with butter, bacon, lots of fats, and never heard the word STATIN. I think every one that is writing to this forum and complaining about LIPITOR, should make a phone call to PYzier and tell them your side effects, that is the only way anything positive will come from this forum.. thank you for listening... I have called Pyzier and told them as well.

I'm a 38 y/o woman. For 7 yrs I knew my cholesterol has been high. I refused to take cholesterol medication and decided to diet and exercise but that didn't work. I've had 2 children in the past 3 yrs. In May of this year I started having chest pains and palpitations. I had blood tests done. I was given Inderal and also prescribed Zocor 20mg for my cholesterol. It was 243 with and LDL of 178. I took Zocor for a week. I felt so awful. I was weak, I lost my appetite. I was constantly tired. I couldn't even carry my 10 month old son, yet alone care for him. I informed my physician and she changed it to Lipitor 20mg. I thought I was doing fine. I checked my levels again after a month. My cholesterol was 113 and LDL 58. I trusted the doctor knew what she was doing. At the same time I also was taking Omega 3's. I asked my doc to lower the dosage to 10mg. From the time I was taking Zocor and the start of Lipitor. I was feeling tingling and numbness in my arms, hands, fingers, toes, feet and legs. I also was having muscle pain. I asked my doctor about that. She mentioned because of my heart palpitations, it could be symptoms of anxiety and panic. I had feeling of pins and needles throughout my body, not knowing when it would occur. I had muscle pain in my arms and legs and neck pain. I went online to see the side effects of Lipitor and came across this website. I decided to do an experiment. I stopped taking Lipitor 9 days ago. I was on statins for almost 4 months. I don't have the feeling of tingling and numbness, but I still have pins and needles and muscle pain. I have to say, I feel so much better. I hope to get better. I 'd really like to know, how long does the medication stay in your system? What are the effects of getting off it so suddenly. I'd love to feel myself again.

I am a 54 year old male who started taking Lipitor about 4 years ago. It seemed OK at first, but over the next several years I began to have increasing amounts of joint pain after exercise. Nor muscle pain, joint pain. And it seemed to be a result of exercise. By the time I stopped it, I was hurting after everything, not just exercise. I felt better within the first two weeks, but it took about 4 months for me to be able to exercise vigorously again. Over the years I seemed to have forgotten how much vitality I used to have. I am a physician, and because of the long lag time until I felt better, I wondered whether improvement might have related to other factors, so after about 5 months I decided to restart Lipitor. It surprised me that after just one dose, I got back all of the joint pain and fatigue when I was at my worst on Lipitor. I was really hurting. Needless to say, I didn't take any more.

Coincidentally, a physician friend of mine who had statin induced polyneuropathy had a similar experience. After his symptoms went away he found that after only one dose the entire polyneuropathy came back.

Stopping and restarting the drug is a way to test the correlation between the drug and the side effect. For such a large spectrum of side effects to recur after only a single dose, it argues that the problems that my friend and I had was due to some sort of immune memory response. I have not seen this in the medical literature.

I am off it now for about 8 months and am able to comfortably play singles tennis and jog - much more energy (and I took 200 mg of CoQ10 a day with the Lipitor).

I was given 40mg Lipitor for elevated cholesterol. I took it until I started having muscle weakness .I am a retired nurse of twenty five years, and knew this symptom was not correct. So I stopped taking the medication and told my doctor of this.He did not protest in any way.My symptoms now include;two torn ligaments, sob,mental deficits, muscle wasting, night sweats, weakness,h/a's, and more. I have not taken Lipitor for two years now. Damage is done.My doctor said it should be out of my system by now. Is this a cover up?

I have been on lipitor about 4 yrs. I am a runner and keep tract of my times. I have been losing about 4% of my speed each year and have recently had a large amount of muscle fatigue. Today a ran a 940 pace and thought I was not going to make it home. Three years ago my average pace was 805. Could the 20mg dosage be causing this problem?

I am taking lipitor for 3 months and sinds one week i have pain in my left arm and a constant twinkle in my left hand. i stop now for 3 days and wait to see the results

I am a 46 y/o male whom took lipitor 20mg for about 10 days. It was the first medication taken for me aside from occasional antibiotics. Within a week I began to develop severe nausea, weakness, postural dizziness and worst of all, chest pain at rest! I took my last dose last Saturday 8/9/08. Because of the chest pain, I went to the ER on 8/10/08 and discharged the next day after I ruled out for an MI and a negative exercise stress test. My chest pain recurred on 8/12. This AM awoke with nausea, dizziness and chest pain again. I'm going to have an adenosine stress test this PM. I consulted a pharmacologist yesterday about the metabolism of Lipitor and she told me indeed these side effects are not uncommon and in my case, Lipitor will not be eliminated from my body until probably this Sunday or early next week. Anyone experience what I'm feeling?

I HAVE BEEN ON LIPITOR FOR ABOUT A MONTH NOW AFTER HAVING 3 STENTS PUT IN I AM A 50 YEAR OLD MALE THAT HAS ALWAYS BEEN ACTIVE IN SPORTS, MY LIPITOR SIDE EFFECT ONLY STARTED A FEW DAYS AGO, I HAD SEVERE PAIN IN MY RIGHT SHOULDER SO BAD I COULD HARDLY USE MY ARM THE PAIN GOT SO BAD LAST NIGHT, WE WENT TO THE ER, NO PROB FOUND JUST INFLAMMATION, SO THE DR PRESCRIBED MOTRIN 800 AND A MUSCLE RELAXER, WHICH DID GIVE ME SOME RELIEF IN ABOUT 25 MINUTES .
TODAY WHILE SHOPPING I NOTICED A PAIN NOW IN MY LEFT SHOULDER AND NOW THROUGH THE DAY IT IS JUST ABOUT AS BAD AS THE RIGHT ONE THEN AFTER DOING THIS RESEARCH I WILL AS OF RIGHT NOW STOP TAKING MY LIPITOR I WILL POST MY UPDATE TAKE CARE

I am a 35 yr old male and have been taking lipitor about 7 yrs. I have a genetically high cholesterol and it has been up to 275. On lipitor its around 175. Over the years I have been on this drug I went from being a normal weight and active to pretty much lethargic and sedentary due to lack of energy and gained ~50 lbs. I couldn't sleep. I got random nausea and fogginess in my brain to the point I could not remember how to perform my job. I usually had minor aches and was bloated. the past year everything has gotten much worse. For a year now, I have been getting large rashes on my body that itch severely and no medications have worked to alleviate them. I found out recently from my doctor that I have a genetic marker in my cholesterol that makes me 3 times as likely to have a heart attack. Its a portion of the cholesterol, i think its called LDL-b or something like that. Anyways, My doctor prescribed zetia to help with my cholesterol since the lipitor wasn't doing it alon. I begin feeling very sick when taking the zetia and after a week or two stopped it. The problems didn't end. As long as I remained on the lipitor, the problems seemed to continue. Its like the zetia released a dam of problems. I stopped the lipitor 4 days ago and have noticed that I feel energy coming back to me and the rash is starting to go away, but I ache severely all over. My shoulders, forearms, and legs are so sore and painful that I can't do anything about this except sleep so I don't feel the pain. I am also very weak feeling and I notice stiffness in my fingers and my grip is very weak compared to how it normally is. I have nausea and stomach cramps and constipation. I feel miserable. I notice its worse in the morning and gets a little better towards the afternoon. I typically took my lipitor in the morning. I do not know if there is a relationship here. Please advise on any help you can provide.

KMJ
07-30-08

I have been on Lipitor for about 4 years. Now I have an arthritic right knee and the left knee has a little bit of arthritis. My arthritis started getting really bad in both legs my left leg was just as bad as my right leg. Muscle pain was tremendous and getting up and down stairs. furniture, and the car. Then the day before Memorial Day I could hardly move, I thought I was losing both my legs. I could only walk a little bit. No energy. I too had blurred vision with this drug but the doctor said that it probably was just my diabetes. I hurt from the shoulders all the way down to the ankles..It felt like every muscle group was involved. Earlier this year the doctor put my Lipitor up to 40 mg from 20 mg even through my ldl was only 93. My last ldl was 67. The doctors say your cholesterol cannot go to low but I am wondering with all the side affedts I had. I took myself off Lipitor on Memorial Day this year and I feel better. The pain is gone except for the arithritic pain but it is not as bad as what it was on Lipitor. Soo I am done with statins I will lose weight and exercise.

I started taking Lipitor 12 years ( 1997 ) ago as my Cholesterol was at 315. I was always athletic but had a crappy diet. My Cholesterol dropped to 200 within a year. However, in 2001 I ruptured my left Achilles playing tennis. Thought nothing much and that I hadn't stretched enough. Recovered from that and started playing tennis again in 2002. Within three weeks of playing again, I ruptured my RIGHT achilles! At that point I started to question the effect of Lipitor on muscles/tendons with various medical "professionals". ALL said it was nothing to do with medication. I quickly developed a tingling/numbness in both feet that doctors said could not be happening but it WAS!

I've had MRI's, nerve conduction tests, wondered if it was diabetic, alcohol, etc. Finally found sites such as this where real life experiences validated my concerns over this statin. I told my Dr. I was quitting Lipitor last Monday, she had no problem with that. This is Saturday night and I'm sitting here with a NOTICEABLE decrease in my numbness/tingling in both feet that I've had for the past TWELVE YEARS!!

I hope that the statin did cause my "mild sensory polyneuropathy" as was diagnosed in 2002. As of right now, it seems to be getting better in less than one week! I can flex my toes with NO pain and my feet don't feel like dead weights.

I WILL NEVER USE A STATIN AGAIN!

I would encourage every patient on statins to read the recent article (Feb. 2008) by Dr. Peter Langsjoen, MD/Cardiologist: http://www.lef.org/magazine/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm

The following information from this article is pertinent to complaints of muscle pain/weakness and fatigue:

"All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. This has nothing to do with diastolic blood pressure, but rather represents impairment in the relaxing or filling phase of the cardiac cycle. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. Thus, if diastolic dysfunction is severe, it can result in congestive heart failure. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10."

I hope this information will be of help to patients suffering adverse reactions from statins..

I am a male of 67 years old. I took Lipitor for a year, and after a few months of taking it, I felt muscle pains in my arms and shoulders, as well as my back. I felt weak and could hardly put my socks on by myself. I told my family doctor that I thought the problem was caused by LIpitor. He said it couldn't be possible, but he couldn't figure out what was wrong, so he sent me to a rheumatologist, who gave me an initial diagnosis of polymyalgia rheumatica. I went back for a checkup, and although the sed rate was normal, the C-reactive protein was elevated. He felt his diagnosis was an accurate one. He prescribed prednisone for me. I had some doubts about it, since I am diabetic, and was concerned about the elevated blood sugar it might cause. Well, it did elevate my blood sugar, and I weaned myself off it within three months. My blood sugar went back to normal, and while the prednisone helped the symptoms of muscle pain and aches, after I stopped it, the pain returned with a vengeance.

About a year passed after discontinuing the prednisone, and I felt worse and worse. Any time I engaged in physical activity, such as yard work, I was almost incapacitated for two or three days. I felt weaker and weaker, and by now, my activity is about ten per cent of what it was three or four years ago. I am unable to do anything physical without paying a heavy price.

I would tell the doctor that I felt the problem was caused by the Lipitor. He would dismiss my comments, saying that the pain should have gone away after discontinuing Lipitor. He sent me back to the rheumatologist with results of recent blood tests. Both the sed rate and C-reactive protein were normal. The rheumatologist touched my back and other areas, which caused me to jump. He said it might be fibromyalgia. I told him again that I thought it was caused by the Lipitor. He said the same thing my GP had said: if it had been the Lipitor, the pain would have gone away when I stopped taking it. I know the Lipitor caused the pain, because I tried red yeast rice for a couple months. The pain increased to almost unbearable, so I discontinued the red yeast rice. If I were not susceptible to the pain from the Lipitor, would the red yeast rice have increased the pain?

So here I am with a fuzzy diagnosis from the rheumatologist, and no clue from my family doctor (that he will verbalize, at any rate). My life has gone steadily downhill. I used to be a strong, active person, but now I can do very little, and my strength is a shadow of what it formerly was. What can I do?

This is a follow up to my July 5th post, I am the 42 male, it has been almost two weeks since I stopped Lipitor, all the side effects are completely gone. Muscle pain, numbness in the fingers etc..It looks like it takes at least a couple weeks for the substance to completely exit the system. I know not everybody is the same, but at least this give hope that there are cases where the condition is reversible.

Here are some more side effects that I encountered during my ordeal with Lipitor. A week after I started the medication, I started experiencing blurry and decreased vision, this used to go away and come back sometimes, I could swear I always had 20/20 although I never went to eye doctor, but I never needed glasses all my life, if fact any type of glasses will blurry my vision and make me dizzy. I had my first eyes exam a couple days after I discontinued Lipitor, guess what? I have 20/20 vision.
More details about the back and right arm pain, not only the pain was unbearable, I felt my muscles sagging and they did not have any strength, this thing sucked the life out of my muscles, it made me very tired and easily irritable. My fist victim was my little baby ( my beautiful 4 year old), her daddy couldn’t hold her anymore, I even avoided staying close to her, because anyone who touches that right arm will make it feel like another deep stab to the arm deep into the bone. I have never experienced pain like this. I knew about toothache when I had a cavity at 23, but it was fixed and went away, I even experienced the pain of a broken arm at 16, but this thing was something else. The other victim is my wife, I stopped doing stuff, I used to be a very active dude, I do stuff on weekends with family and even every day after work ( you name it, park, boating, swimming pool, malls etc..). It felt like I was dying one piece at a time, going down the tubes fast with no clue of what was wrong with me.

My doctor started me on Lipitor over a year ago. I started having muscle pain in my shoulders but didn't equate it to the meds until I was watching television one day and a Lipitor commercial came on. It said that some people experience muscle pain.....I thought HALLELUEH THAT'S WHAT IT IS.....I stopped talking the meds and went to see my doctor who immediately changed my meds to Zocor.....guess what? The same thing happened. Went to see her again and she switched to Crestor.....same thing happened....so I started doing my own research and was amazed at what I learned and bewildered as to why my doctor was acting like I was some whining baby.

No problem, I say to myself and stopped the meds. That was last November, in January I had my yearly physical and blood tests were ordered for me in December......guess what.....my triglycerides were still high so my doctor orders Antara. It didn't say "cor" anything so I'm thinking it's not the same stuff. No, it wasn't the same stuff it was WORSE!! Within three weeks I was crying I was in so much pain. I called her and got her nurse practitioner who says that my doctor said to stop taking the pills and the pain will go away. I call back and say, "you don't understand, I can't sleep, I can't move, I can't function the pain is so bad." After several calls back and forth, and let me tell you I NEVER call my doctor unless something is incredibly wrong and that is less than rarely. Well, my doctors partner tells the nurse practioner that they will not prescribe narcotics for me. WHAT? Who asked for narcotics? I needed relief from this pain.....I would have gone for amputation!!!

So I change docs...more blood work.....high triglycerides, I refuse to take any statins. She says she has something for me that will not cause muscle pain and hands me samples of Welchol.....this one took less than a week for increased muscle pain...again I wanted to trust, but guess what i learned when I went to the Welchol site? The first side effect listed? Muscle pain.

Called the new doctors office to let them know that I was experiencing pain again and was told to stop the Welchol (which I had already done) and take Red Yeast Rice and have bloodwork done in 3 to 6 months and come back to see her. Oh no! Not without research and guess what? A side effect of Red Yeast Rice? Muscle pain.

It has been 4 months since I stopped taking the Antara and took Welchol for a week in that 4 months. Sometimes my shoulders/neck and arms don't hurt too much. Unfortunately most times they do. Both doctors insist that the pain cannot be from the drugs because the drugs have left my body. The new doctor said I probably have myolgia just because I'm 52 and that it's just a coincidence that it happened while taken the drugs but then goes on to agree that I must be "sensitive" to statins. Both doctors treat me like I'm stupid and nuts all balled up in one. I am frustrated and in pain most of the time. I have been trying to find out how long to expect this pain and am dismayed to learn that it can be years or never go away.

Yes I have high triglycerides (so does my mother and she experiences the same kind of pain so refused to take statins) and I've been warned that not taking statins could cause pancreatitis and/or heart problems. My question to that is - "then my choice is chance the heart stuff or live an incredibly painful life?"

I'll take my chances and pray for the best because right now my quality of life stinks!!

Found this on a web site listed at the end.
Very scary!!! COQ10 is a must when taking any statin drugs your body needs it for your
muscles. Other statin drugs may be better.

Numerous adverse side effect reports have implicated Lipitor as a possible cause for severe neuromuscular degeneration. Some people who have been using Lipitor for two years or more report symptoms similar to multiple sclerosis or ALS - Lou Gehrig's Disease - in which they are losing neuromuscular control of their bodies.

For instance, in an article entitled "Life After Lipitor" that appeared in the newspaper Tahoe World on January 27, 2004, Tahoe City (California) resident Doug Peterson began having serious neuromuscular problems after taking Lipitor for two years. He began losing muscular coordination and slurring words when he spoke. Then he lost balance, followed by loss of fine motor skills - he had difficulty writing. He went from doctor to doctor, trying to figure out what could be happening. Finally one doctor suggested that he stop taking Lipitor, and the downward health spiral stopped and his health is now slowly improving.

These adverse effects have begun appearing in peer-reviewed medical journals, and numerous people have reported similar symptoms at public adverse effect reporting websites such as medications.com. People have reported "trouble swallowing, trouble talking and enunciating words, feeling fatigued all the time, neck aches," "motor neuropathy which mimics ALS," "Blinding headaches, nausea, vertigo, disorientation, memory loss, extremely dry eyes, pain and stiffness in my neck and calf muscles, abominal pain," and "Muscle pain, weakness, spasms, buzzing in right leg. Can't hold arms or head up in vertical position for 2 minutes without extreme pain and weakness."

How could Lipitor potentially cause this kind of harm to so many different parts of the body? Lipitor is a "statin" drug which inhibits the production of cholesterol in order to lower LDL cholesterol counts. By limiting the production of cholesterol, Lipitor may be indirectly causing membrane degeneration in neural and muscle tissue.

The problem is this: cholesterol is essential in your body for many functions. It forms part of what is called the cell membrane - the outer layer of every cell in your body. It helps transport and pack the major components of the cell membrane, called "phospholipids," that are made from essential fatty acids (EFAs). Without sufficient cholesterol we would die, because our tissues are constantly being repaired and replaced with new cells.

Our body produces several thousand milligrams of cholesterol per day to carry out these essential functions, and each day the excess of cholesterol is supposed to be naturally recycled. If your body doesn't have enough new cholesterol each day, you cannot repair and replace your cell membranes and they will eventually degenerate.

The continual recycling of cholesterol happens naturally when you have sufficient ascorbate, another name for vitamin C. Excess cholesterol is naturally converted to bile acid and then excreted. But if you don't consume enough vitamin C (about 2000-3000 milligrams per day for an adult), cholesterol builds up in your bloodstream. It is here that doctors make a critical error: instead of telling you to take more vitamin C, they prescribe Lipitor.
If Lipitor and other similar statin drugs are in fact indirectly causing neural and muscular degeneration, this is a very serious matter indeed.

There are twenty million people in the U.S. on Lipitor alone, and probably millions more on other statin drugs (Zocor, Pravachol, Mevacor, Altocor, Lescol, Crestor, etc.). Are they all going to become victims of cell membrane degeneration and nervous system problems? There are few long-term studies that bear out the safety of these drugs, and side effects such as "muscle pain or weakness" are just classified as a reason for some to stop the medication rather than an indication of something very wrong with the drug.

What is most horrifying about this problem is that cholesterol balance can be achieved without drugs, simply and safely by taking 2000-3000 milligrams of vitamin C per day for an adult. Unfortunately, vitamin C was misclassified as a micronutrient in the 1930s and 1940s, rather than an essential nutrient involved in dozens of body processes. Our health authorities recommend that we take only 60 milligrams per day, barely enough to prevent scurvy.

It is my hope that people on Lipitor and other statins learn that they do not need to take these potentially harmful drugs.

For more information about the connection between vitamin C and the prevention of cardiovascular disease, see the article Natural Therapy for Cardiovascular Disease, or visit the research website of Dr. M.
******

I have been taking 10 mg.lipitor for 3 years or more....I seem to loose track of time because my memory is so bad....I ache and hurt all the time...I have severe back pain...Sometimes my back hurts so bad I cannot do any of my housework....All of my muscles just ache and hurt...I am 47 and I am steadily going downhill with my health....I feel nauseas for no reason...I have headaches...I told my doctor all of these symptoms and she has run all kinds of tests...They all come back normal...She has no idea why I have no energy and why I feel the way I do....She set me up for a stress test because I was complaining with chest pains...That test was normal...She set me up a sleep study...I am now sleeping with a cpap machine with the pressure set at 11.4...After going through all of these tests, I still feel like crap...I was sure after the sleep study things were going to get better...Then I started having such bad pains in the bottom of my feet...I could just be laying in bed and my feet would be throbbing with pain....and when I would try to get out of bed I could hardly walk...After about 5 or 10 minutes I could walk okay but the pain was still there....This is when I started looking around on the internet to see if I could find out what my problem was...I found this site and begin reading all of the side effects of lipitor...I knew right away that this was most likely my problem...I stopped taking lipitor 3 days ago....The only difference I can tell so far is that the pain in my feet is not as bad...I can hardly wait for the next morning because I am so anxious to see how I am going to feel...I am just wondering how long will it take for me to get back to my old self....oh I forgot about my stomach pain...The bottom of stomach hurts so bad at times...I told my doctor and she examined me and ran more tests but found nothing....My doctor does not know I have stopped taking lipitor...I have read that taking vitamin c or fish oil will help with lowering cholesterol..Does anyone know if this really works???

Trying to figure out if my back pain is like others. The pain is in the lower left side and groin area of both hips. I have trouble reaching my feet to put on shoes and socks. Ive been on Lipitor 20 for about 5 years and have never had a problem before. This started about 6 months ago and even with heat and stretching it seems to get worse. It hurts when I stand for any length of time. It hurts to walk or run. It hurts very badly if I try to straddle something like an ATV or a horse. When I sleep (if I can) I sometimes have to put a pillow between my legs and lay on my side because it hurts a lot to bring my legs together. Feel free to email me at ******

Let me begin by telling you that I am a nurse with 28 years experience. My father is 76 years old with a history of cardiac problems. He has been on Lipitor for 8 years. In the past two months he has developed muscle pain that had gotten to the point he could hardly walk. His doctor diagnosed him with "arthritis." His joints did not hurt and I questioned his diagnosis. What he has is fibromyalgia. Muscle dysfunction caused by Lipitor. We have taken him off of the drug and he is improving. In place of Lipitor he now takes 2000 milligrams of vitamin C daily. Vitamin C is a natural way to control cholesterol. In my opinion I suggest anyone taking symvistatin in any form should stop immediately. It is a very dangerous drug. If you think this is what you have please request your physician order the following two tests.....CPK and serum myogluten levels. Cholesterol is very important to muscle function and that is why it is produced by the body. Zocor, Lipitor, ( symvistatin) inhibits the production thus lowering the level. Let me add that prior to this condition onset my dad was riding his bike 3 plus miles a day and could out walk me any day of the week. This drug has disabled him. We are hoping for a full recovery but that is yet to be seen.
Thank you ******

I am 54, I was diagnosed with diabetes type l in 2003. I started showing high cholesterol levels about 2 years ago. When it reached 280 I was prescribed Lipitor 10 mg at first after no improvement it was increased to 20mg. I was very much against this. I have problems with muscle pain, and dizziness.
I checked into an alternative from a doctor who is an MD but prefers natural solutions if possible. I stopped the Lipitor without the knowledge of my primary physician and started taking fish oil 3600mg daily in the evening.
9 weeks later both my cholesterol and triglycerides were normal. I told him about the fish oil, but he wanted me to continue the Lipitor, because diabetics should be on some type of statin medication to help protect the heart. I have visited a couple of sites and haven't anyone talking about liver function problems. I have had an ultra sound for my liver which showed some problems, I am still waiting on some of the tests to return. I also have an appointment to schedule a liver biopsy. When reading my first lab results his first words were." Your results are uncommonly abnormal, stop taking the Lipitor, I am going down and get an ultra sound set up for you." "You might be thinking it could be the diabetes causing this. My diabetes is completely under control, and haven't tested high sugar levels since first diagnosed. I don't drink or smoke. I would like to know if others have had problems with liver function tests being abnormal. Please everyone remember my doctors first response to the abnormal tests stop the Lipitor immediately, it wasn't let's run some other tests to see the cause, because you need the Lipitor as protection for your heart. This medication works in the liver which we only have one of, and it is an extremely vital organ for maintaining health on several levels.

My doctor increased my Lipitor from 10 mg to 40 mg after my physical in January. My cholesterol was only 182 and my LDL was good. I am now being checked for rhabdomyolysis - a rare but serious complication from the muscle pain and weakness caused by the Lipitor. I never had these problems while taking 10 mg and I have no idea why he increased my dosage so much. I am miserable with neck, shoulder, and back pain and have been for a month. I thought I had hurt myself at the gym and have even been seeing a chiropractor for the pain. My urine is very dark, indicating possible kidney damage and I am so tired I can hardly make it through the day. My depression has worsened despite doubling the dose of my anti-depressant and I have no motivation to do anything. I am looking for an alternative to statin therapy, as I am a 38yo insulin-dependant diabetic and am at a higher risk for cardiovascular disease. Any suggestions out there on alternatives?

Can Statins Cause Chronic Low-Grade Myopathy?
Statins (hydroxymethyl glutaryl coenzyme A reductase
inhibitors) are highly effective drugs for reducing serum
cholesterol and low-density lipoprotein cholesterol levels.
Clinical trials have shown that they also reduce risk for
coronary heart disease events, coronary procedures, and
stroke by about one third (1). Millions of people in the
United States and worldwide are being treated with statins.
In clinical trials and in clinical practice, statins have proved
to be remarkably safe.
The one notable side effect of statin therapy is myopathy.
A small fraction of patients who are treated with
statins will develop severe myopathy (2). In the worst cases,
severe myoglobinuria, acute renal failure, and even death
can occur. The incidence of severe myopathy is low, perhaps
1 in 1000 patients (2). Predisposing factors for severe
myopathy appear to include advanced age, relatively low
body weight, female sex, certain medications, use of multiple
medications, multisystem disease, and acute illnesses
or major surgery (3). If statins were avoided or used in low
doses in these circumstances, it is likely that the incidence
of severe myopathy could be greatly reduced.
Less severe forms of myopathy undoubtedly occur. In
some patients, fatigue and muscle pain and weakness develop
with moderately high serum creatine kinase levels
but not acute renal failure. In these cases, the myopathy
resolves when statin therapy is discontinued.
Still more patients report various muscle symptoms—
fatigue, pain, and muscle weakness—but have normal creatine
kinase levels. These symptoms probably are unrelated
to statin therapy in many patients. In middle-aged and
older people, muscle, joint, and tendon symptoms are very
common. Naturally, if a patient takes a medication that is
believed to produce muscle problems, symptoms are often
attributed to the medication. On the other hand, the major
controlled clinical trials have not detected a higher prevalence
of muscle symptoms during statin therapy versus placebo
(1). This failure of detection has generally led clinical
trialists to conclude that statin-associated myopathy with
normal creatine kinase levels essentially does not exist or
that, if it does exist, it cannot be detected above the “background
noise” of muscle symptoms in the general clinicaltrial
population.
Many physicians in clinical practice nonetheless believe
that they can identify a subset of statin-treated patients
who have a unique set of statin-related muscle symptoms.
Some patients clearly relate the onset of muscle
symptoms to initiation of statin therapy. These symptoms
may abate after discontinuation of therapy, only to reappear
when statin therapy is restarted. The number of such
patients is not large, and thus it may have been impossible
to identify them in large clinical trials.
In this issue, Phillips and colleagues (4) report on a set
of studies in four patients who had muscle symptoms during
statin therapy that resolved during placebo use. Quantitatively
measured muscle weakness also resolved during
placebo use. Muscle biopsies were performed in three patients
during statin therapy and then during placebo use.
Several pathologic changes were seen on biopsy specimens
obtained during statin therapy: increased lipid content of
mitochondria, fibers that did not stain for cytochrome oxidase
activity, and ragged red fibers. The authors suggest
that these patients had statin-associated myopathy with
normal serum creatine kinase levels.
Despite the study’s small size, we cannot dismiss these
observations as random variation in muscle structure.
However, these highly suggestive results are clearly preliminary.
The number of patients was small, and all appropriate
controls were not used. Nonetheless, this study is novel
because it used quantitative measures of muscle strength
and muscle biopsy to address the question of myopathy
with normal creatine kinase levels during statin therapy.
To be confirmed, the current data would have to be
extended to many more patients in whom muscle symptoms
are closely correlated with statin use. Reproducibility
of symptoms during therapy and symptom resolution after
discontinuation of statin therapy would be necessary. A
definitive study would have to be carefully designed and
executed. It would need to be double-blinded and placebocontrolled
and include sufficient numbers of patients to
provide a valid statistical comparison. In addition, investigators
would have to carefully consider the appropriate
selection of patients. The development of a registry of candidate
patients at multiple sites could facilitate a multicenter
study.
Is a carefully controlled, sizable study of this type
worth the investment of time and effort? To date, no evidence
indicates that prolonged statin therapy leads to permanent
muscle damage or progressive myopathy in patients
with normal creatine kinase levels. Controlled
clinical trials attest to the general safety of statins, and
symptomatic side effects appear to be limited to a relatively
small proportion of treated patients. In addition, no therapy
prevents or treats statin-induced myopathy, short of
withholding the drug. On the other hand, statins are being
prescribed to millions of people, and are usually continued
throughout the patient’s lifetime. It is certain that statins
cause myopathy in some patients. For these reasons, a valid
argument can be made for a more extensive study of lowgrade
myopathy in patients treated with statins.
In the meantime, physicians should recognize the great
benefit of statin therapy in high-risk patients and their
documented safety for most patients. For high-risk persons,
the proven efficacy for preventing cardiovascular disease
outweighs the unlikely possibility of permanent muscle
damage. Phillips and colleagues’ preliminary results
certainly do not provide adequate information on the spec-
Editorial
www.annals.org 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 617
trum, scope, or prognosis of myopathy with normal creatine
kinase levels during statin therapy. For these reasons,
prescription of statins for eligible patients should continue
despite the current results. Moreover, before discontinuing
therapy, physicians should carefully evaluate any patient
receiving statins who reports muscle symptoms. In most
cases, the symptoms will be found not to be consistent
with chronic myopathy, and often they will not be related
temporally to statin treatment. High-risk patients in particular
should not be deprived of major cardiovascular risk
reduction just because they display symptoms not clearly
documented to be closely related to statin therapy.
Despite these comments, the actions of statin on muscle
metabolism and structure deserve further investigation
to clarify the confusing area of low-grade myopathy apparently
associated with statin use in a few patients.
Scott M. Grundy, MD, PhD
University of Texas Southwestern Medical Center at Dallas
Dallas, TX 75390-9052
Current Author Address: Scott M. Grundy, MD, PhD, Center for
Human Nutrition and the Departments of Clinical Nutrition and Internal
Medicine, University of Texas Southwestern Medical Center at Dallas,
5323 Harry Hines Boulevard, Y3.206, Dallas, TX 75390-9052.
Potential Financial Conflicts of Interest: Honoraria (from Merck &
Co.; Pfizer, Inc.; Bristol-Myers Squibb; and Bayer); Grants (from Merck
& Co. and Pfizer, Inc.)
Ann Intern Med. 2002;137:617-618.
References
1. Executive Summary of The Third Report of The National Cholesterol Education
Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment
of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;
285:2486-97.
2. Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis
. N Engl J Med. 2002;346:539-40.
3. Pasternak RC, Smith SC, Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant
C. ACC/AHA/NHLBI clinical advisory on the use and safety of statins (1)
(2). J Am Coll Cardiol. 2002;40:567-72.
4. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, et al.
Statin-associated myopathy with normal creatine kinase levels. The Scripps Mercy
Clinical Research Center. Ann Intern Med. 2002;137:581-5.
© 2002 American College of Physicians–American Society of Internal
Medicine
Editorial Statins and Low-Grade Myopathy
618 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 www.annals.org

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