Lipitor and statins

I posted several months ago on this string and wanted to update. I had bloodwork done for the 1st time since I quit the 20mg of Lipitor in August. LDL went from 123 to 210. Total Chol went from 191 to 285. HOWEVER all shooting pains I had been experiencing in legs, feet, and chst are GONE! Went back to my Dr. today, told her that same result and my serious objection to taking any kind of statin and she prescribed CRESTOR while telling me it was more potent than Lipitor! WTF!!!

I refuse this course, am drinking 30 - 40 ozs. of water each day now like I should have been, doubled my CoQ10 to 200mg/day, finally getting back into the gym to lose weight and get the HDL up from the level of 36 it is now. also started to drink the new yogurt type "shot" of Promise for cholesterol that provides 2 grams of plant sterols per day.

I will not take statins ever. I WILL find a natural way to keep my Chol under control. I've also been convinced that you don't have to be at or under the 200mlg of total chol to be healthy. Look at your C Reactive Protein and Homosiytes (sp?) If they are in range you should be good.

I know Lipitor was the cause of my rupturing each of my Achiller tendons a year apart while playing tennis in my late 40's Muscle pain soon followed.

About eight years ago I felt heaviness in my chest along with some pain/discomfort when doing hard physical labor and occasionally in the hot-tub. Following my doctor’s advice and an angiogram, a stint was placed and medication administered – Lipitor and plavix I also went through a 6-month program for cardiac recovery including dietary changes and a proper exercise program. About six month following that I gradually just stopped taking my Lipitor and plavix and returned to my old eating routine and other life-style. I don’t smoke (never did) and don’t drink or otherwise indulge in any recreational drugs. I’ve never been hypertensive with blood pressures typically at 115/68. I maintain a trim and healthy appearing body just naturally or genetically. I eat lots of red meat, not a lot of vegetables, drink gallons of orange juice, and eat much more junk-food than I should. About six years after that (near heart attack) event I was given a “stress test” by my physician… I was then 61 and tested at the level of a 38 year old! Two years after that I had a significant heart attack out in the middle of nowhere! It took almost 6 hours to get me to an emergency room in Spokane, Washington (that’s a story of its own). That was on a Thursday – I was back to work full-time the following Monday (four days later). This time around with more drugs than I could swallow in one gulp! Lipitor, Plavix, Coumadin, aspirin, and carvedilol. The combination or amount was more than I could tolerate and I was weaned off all but the Lipitor and aspirin within a year. My heart has returned to nearly full-function and I have no physician imposed restrictions. All that said, I’ve been gradually developing muscle soreness (pain, actually) in my fore-arms and legs. I’ve been growing more lethargic and tired with each passing month. I’m now 65 and feel that the Lipitor is inhibiting my health… I want to get off it and be “normal” again. Or is it just being sixty five? Can I just quit taking the drug? Leaving only aspirin for blood thinning and the hope of a better diet for cholesterol control.

Hi I started taking Lipitor when I was about 41 and gradually noticed a big toe becoming numb. Then later another toe became numb. I had just started swimming about this time with fins and thought at first it may have been caused by them. But then I stopped swimming and the numbness continued. I visited a Neurologist a couple of years ago who tested for everything and found some peripheral nerve damage to the feet. I said the only thing I could think of was Lipitor. He said here was no conclusive evidence it causes this but explained how nerves are made of Lipids and lipitor limits the production of lipids. I stopped taking it but later my GP said I need to go on something for my cholesterol. He put me on Crestor. I took a Lipitor the other week and my toes tingled that night. So I am convinced it is Lipitor. I am not sure how to reverse the damage though.

No hearing loss in family history. Doctor put my father on 80 mg Lipitor, 1-1/2 years latter he started having trouble hearing. I was taking 40 mg Lipitor after 2 years my left ear went bad, 9 months latter my right ear went bad the same exact way. The ears went bad with a tinny sound to all when the hearing came back the 3 kHz area was very low. I have just put this together the recently. This is not a coincidence, I am sure Lipitor caused this. I also think this caused me to go through Hell from hard bump break outs on my body, had me spend thousands hunting for a parasite that was not there. It was not a rash, small bumps with a hard center.

I am a 65 year old female taking 20mlg of lipitor for almost 10 years. All of a sudden I started having severe pain, shaking and weakness in the calf muscle. The pain is unbearable. Doctors after doctors including a cardiologist, rhoumatologist and internist don't know the reason. I have stopped lipitor for 3 days. I cry and pray to god to help me everyday. I cannot exercise which is my passion for many years. I am hoping the lipitor is the reason and not something else. I have to wait and see. But I suspect it is.
SR
I do have nausea, depression and low back pain and arthritis and frequent headaches.

Went off simvastatin in March, all pain went away within a couple of months, but muscle weakness in legs remained. In October, found out my cholesterol is sky high, over 325. So Dr. wanted to try Crestor 5 mg. Within 1 week, I had overwhelming fatigue, could hardly stay awake during the day and the weakness in my legs was getting worse. So I just went off Crestor. Frustrating!!

Get off the Lipitor, me and me husband, both had the severe joint pain. The pain moved from one joint to the next. It would be in the shoulder, then the next day or so, it would move to our feet, then to the hand and wrist. It would swell , so bad, that it felt like, that part of the body was going to burst !!! My husband was on LIPITOR for 1 1/2 years, before it hit him. Doctors thought it was gout, and my husband was walking on a walker ,at 49 years old, and never being unhealthy. I was on LIPITOR for only one month, after a stint was put in my heart. Believe me, it is not the stint , it is the LIPITOR. I knew what it was when it got in my joints, so I went off it right away. It still takes about 2 weeks to get it out of your system. I now know of other people, who are on LIPITOR, that have severe muscle cramps. If this is happening to you, then you can not take anything with STATINS , in it. If you are allergic to STATINS, it can cause another muscle disorder , that can destroy your muscle tissue.

I have extreme thumb spasms, often both thumbs at the same time. i had an episode a few weeks ago of a severe pain in my hip running down my leg. I was in bed all weekend as a result and needed a cortisone shot to help relieve the pain. I forgot a name right after they tell me and I am only 50 years old. I lose my balance and sometimes almost fall and have vertigo every now and then. I wonder if all these symptoms are from lipitor. I have been on it for at least 3 years.

I have been on 20 mg Lipitor for years, and as I also have Rheumatoid Arthritis, all my symptoms have been blamed on that. I have been diagnosed with Fibromyalgia and put on Lyrica because of the muscle aches and depression. My lower back, hurt in a car accident when I was 17 years old, had gotten so much worse that I had 12 steroid shots in my lower spine a couple of years ago. They didn't help my back at all, but my blood sugar went from normal to diabetic levels, and I am now on Byetta to try to lower it.
I am a 56 year old woman who was the math specialist in a school district until last December when I had to retire early. My back pain was so severe that I could no longer go from school to school carting materials. I could barely make it from the parking lot to my office. Mentally I was not ready to retire, but physically, I was (and am) a wreck. I have severe muscle pain in my shoulders, sometimes one or the other, but always present. I have tingling in my right hand, especially in my fingertips, and have trouble gripping and drop things easily. In the last few months the pain in my right thigh and calf has gotten unbearable. I thought at first it was sciatica, but I have had sciatica before, and this isn't the same, although there is tingling, burning , but the pins and needles is so deep in the muscles I have just sat and cried, or wanted to scream. I have wished I could just cut my leg off. And...I am on some pretty heavy duty pain killers for the RA: a small dose of prednisone plus Enbrel, Methotrexate, and Vicodin, and this pain is cutting right through all these meds. I get severe headaches, I went off Lipitor for 5 days and seemed a little better, but then went back on, and it came back.
Since I no longer work, I sleep longer, am exhausted ALL the time, have terrible mental fog, am clumsy, cannot stand for more than a minute or so without wanting to scream, cannot walk more than a few yards...just getting to the car is an ordeal. I tell people that I can only shop in shoe stores and furniture stores...the only stores with places to sit down.
I no longer cook or clean, cannot play with my granddaughter, even holding a book to read can be too much, and I love reading. I feel I am just dying bit by bit as I lose parts of myself.
My doctor is really into lowering cholesterol, and has put me on Zetia in the past few months...and it has been in this time that the pain in my leg has gotten unbearable. He wants my cholesterol to be between 50-60, and has said that the Zetia along with the Lipitor will do that. Is this normal or in any way reasonable??? I am having a full blood workup done tomorrow morning, and I want to go off the Lipitor starting the day after.
I came across this web site tonight while looking up Lipitor side effects, and I am shocked. I have so many of these symptoms, and there are so many I had no knowledge of at all. I knew about the muscle aches, but that's all. I hope someone can help me with what supplements and vitamins I should be taking. I started taking CoQ10 a month or so ago. What else should I be taking for my health? I know vitamin C and fish oil, but don't know how much or anything else. Right now I am just stunned with the thought that all of these problems that have left me unhappily retired, exhausted and in constant pain can all be caused from a drug I have been taking to help me be healthier.

If you take lipitor, you will be interested in this.

I have taken it upon myself to do my own studies into cholesterol and heart disease. I painstakingly studied various countries comparing rates of heart disease to cholesterol levels in each country.

From the Data, I can honestly say that I find no relationship between total serum cholesterol and heart disease. More surprising is the data showing higher cholesterol levels associated with less disease and longevity.

Just started today with 40 mg dose of Sortis (Swiss-branded Lipitor).
60-90 minutes later, I am very dizzy, sweating, funny taste in mouth.

I am done... no more. My cholesterol is normal, but recommended as complementary treatment with Glucophage, as I am very slightly diabetic.

I am still spaced out as I write this note. Called the MD to tell him that I the one dose is all that will enter my body.

To send a report to the FDA about Lipitor and the side effects, go to ****** Hopefully, if enough people will complain about this dangerous drug, the FDA will ban it and it will be off the market.

4 months ago started on preastatin 20mg increased within 1 month to 40mg; could not stand up without help; stopped statins at that time. CPK done 157, this was done to show me I wasn't in danger of rhabdomylysis, I continue to suffer with swelling R leg and severe pain. Leg is still swollen 4 months later.....I am professional RN in ICU ,,can't really do my job as necessary...Should I file for disability; or does someone have an answer to provide relief for this malady???

My co worker 's husband was diagnosed with chest pain and heart disease two months ago.They inserted two stents.
They also started him on statins and other cardiac medicines.
Yesterday he went for a walk and came back home and suddenly dropped dead. The cardiologist said it wasn't heart related.
I remember reading how those stents were killing people. I am sure those statins didn't help either.

Moderately high cholesterol and BP 150/90. Was put on Lipitor 20mg and after a week felt more fatigued than usual but nothing much more than this. Had stress test and angiogram which showed 60-70% block in one artery as well as arrhythmia. Cardiologist bumped Lipitor up to 80 mg which I took for 2 weeks. But by then I was suffering most of the effects described in these postings: aches and pains, giddiness, nausea, extreme weakness and fatigue. I took myself off Lipitor and even after one day my head started to clear aches started to diminish, though urine still a reddish color suggesting a lot more flushing out required. And, best of all, the arrhythmia reduced from moderate/severe to mild (which it always used to be before taking Lipitor). This drug is not for me. I'd rather take my chances without it and rely on strict diet, weight loss, etc. It is surprising that the possible side effects are so understated in the manufacturer's descriptions.

I recently lost about 25 lbs and decided after about 8 years of 10 mg of lipitor, to go off of it, cold turkey. I consulted both my MD and my pharmacist about whether or not I should wean, and both declined.

I now feel that my sweats, hot flashes are out of control. I am so hot and tired. I feel as though I cannot do the daily functions that I am responsible for.

I truly had NO side effects that I know of ON the drug. I just figured I'd see how I do now that I lost some weight. I wonder if going OFF lipitor is dangerous?

If anyone knows, please reply!

Thank you!

15 years ago, at the age of 35, I had a major heart attack. After testing, the doctors decided I needed a quadruple bi-pass operation, followed by Lipitor, among other things. I was taking 20mg (the doctor ordered 40mg), but due to financial reasons I took only half. Everything was just great for 15 years. During a routine annual physical this year, my doctor noticed that my liver enzymes were off the chart high. He immediately had me discontinue the Liptor, but stay on all of my other medications. One month later, my liver enzymes were normal, and so was everything else; however, my cholesterol had climbed to 204, and I eat no meat, eggs, or other dairy products. They say my liver damage is permanent. Having had 4 lumbar surgeries and 1 cervical surgery to fuse disks in my spine, I have always attributed my back and other muscle pains to that. Now that I have been of the Lipitor for 3 months, I have not noticed in decrease in pain in these areas.

I have had all the side effects on 10 mg of lipitor for 13 years. My new doctor told me to get off "TOPROL" and take Bystolic (a new blood pressure reducer).

My doctor believes its the blood pressure medication and not the Lipitor.

Anybody has thoughts on this?

question that I have is that has there been any report for side effect sexual for either male or female? If so what was suggested?

I am a 43 year old male in good health that decided to get off lipitor about 3 days ago due to the advice of my physician. I have been on it for 3 years at 20 mg daily. I am an avid runner completing 3 marathons in the last 4years, but lately haven't been able to run more than a mile or so without feeling tightness in my abs, legs, hips, and most recently my hands and elbows have mild to moderate pain. I've been noticing this over the past few months or so. I always thought it was due to over training, but I am convinced these are not normal muscle soreness/strain and I am eager to share my results as to how I feel in a few weeks/months. Today, which is day 3 without the drug, I have INCREASED pain in my hand, and an overall fatigue feeling. Has anyone else noticed this upon stopping the drug? God help all of us. This can't be doing mankind any good other than making the drug companies rich, and unfortunately, most physicians believe that these statins are wonder drugs, and prescribe them like candy.

I am a 51 y/o white female that has been on Lipitor for 2 years. I am 5' 1" and when I had to go on it my cholesterol was 267 I weighed 112 lbs. I was shocked.... my doctor told me weight had nothing to do with cholesterol. She kept a close watch on me and my cholesterol came down...... and then my ex-husband of 17 years and I re-connected and got back together and I moved so I had to get another primary care physician. I took all my meds to her, she also kept a close watch on everything. At this time my cholesterol is down to 109 and I asked if I could stop taking it, as I take quite a lot of meds, due to different things and if I could stop anything it would be great, but she said it I stopped it, my cholesterol would go right back up. So since I am not experiencing any side effects I'm okay with continuing it.

I surely hate to hear what you all are experiencing with your Lipitor..... could your doc try another cholesterol medication?

The only one of my meds that is giving me any problem is TOPAMAX........ that we are using as a Migraine preventative! HORRORS!!! Today is pretty good day. But my cognitive abilities are in the trash... I say the wrong word when I mean something else...... I search my mind looking for a memory...... I am also on disability since 2002 because of the Migraines....... I have has them since 1978, but they got progressively worse over the years until I was sick more days per week, sometimes more than 7-10 days at the time, having to be in the hospital being rehydrated and on IV pain meds.......... and as awful as the TOPAMAX is.....it has been reduced the migraines to approx 2 per month and they do not last nearly as long.

So sorry, I got waaay off topic, but I know that it is not the Lipitor that is giving me the side effects as it the last med I had to go on and I had no new side effects....... but that TOPAMAX is kicking my behind.

I'm a 38 y/o woman. For 7 yrs I knew my cholesterol has been high. I refused to take cholesterol medication and decided to diet and exercise but that didn't work. I've had 2 children in the past 3 yrs. In May of this year I started having chest pains and palpitations. I had blood tests done. I was given Inderal and also prescribed Zocor 20mg for my cholesterol. It was 243 with and LDL of 178. I took Zocor for a week. I felt so awful. I was weak, I lost my appetite. I was constantly tired. I couldn't even carry my 10 month old son, yet alone care for him. I informed my physician and she changed it to Lipitor 20mg. I thought I was doing fine. I checked my levels again after a month. My cholesterol was 113 and LDL 58. I trusted the doctor knew what she was doing. At the same time I also was taking Omega 3's. I asked my doc to lower the dosage to 10mg. From the time I was taking Zocor and the start of Lipitor. I was feeling tingling and numbness in my arms, hands, fingers, toes, feet and legs. I also was having muscle pain. I asked my doctor about that. She mentioned because of my heart palpitations, it could be symptoms of anxiety and panic. I had feeling of pins and needles throughout my body, not knowing when it would occur. I had muscle pain in my arms and legs and neck pain. I went online to see the side effects of Lipitor and came across this website. I decided to do an experiment. I stopped taking Lipitor 9 days ago. I was on statins for almost 4 months. I don't have the feeling of tingling and numbness, but I still have pins and needles and muscle pain. I have to say, I feel so much better. I hope to get better. I 'd really like to know, how long does the medication stay in your system? What are the effects of getting off it so suddenly. I'd love to feel myself again.

I am a 51 year old male. November 2007 jaw pain sent me to the hospital where they found a 99% block in my right coronary artery, yep 4 stent's. Three month late the same this time 2 stent's and two weeks later 2 more. I now have 8 stent's. My DR. put me on several meds including Zocor. The zocor made me very tired and headaches. He change it to Lipitor 10mg. I have been on it for 7 months and a few day's ago I have notice pain in both knee's and hip. I once again find it hard to concentrate, feel sluggish and have headache's. I NEVER have headache's. Stopped taken the Lipitor, hope the pain goes away. It a shame that the medical field is so quick to put us ALL on drug's, how about herb's instead. I'm going to look into a natural way to lower my cholesterol.

I was given 40mg Lipitor for elevated cholesterol. I took it until I started having muscle weakness .I am a retired nurse of twenty five years, and knew this symptom was not correct. So I stopped taking the medication and told my doctor of this.He did not protest in any way.My symptoms now include;two torn ligaments, sob,mental deficits, muscle wasting, night sweats, weakness,h/a's, and more. I have not taken Lipitor for two years now. Damage is done.My doctor said it should be out of my system by now. Is this a cover up?

I have been on lipitor about 4 yrs. I am a runner and keep tract of my times. I have been losing about 4% of my speed each year and have recently had a large amount of muscle fatigue. Today a ran a 940 pace and thought I was not going to make it home. Three years ago my average pace was 805. Could the 20mg dosage be causing this problem?

I was prescribed Simvastatin 40mg four weeks ago and had horrendous side effects almost immediately eg deep depression, diarrhea, bad stomach aches and night cramps in my legs. Last week my doctor prescribed Lipitor 10mg and I feel no better in fact probably worse. The worst side effect for me is the stomach aches and constant diarrhea and complete lack of appetite. There can be absolutely nothing in my stomach any more. Does anyone else have these symptoms? After reading peoples experiences on here I feel I should stop taking this medication immediately!

Karen

I had 95% occlusion of the major artery in my heart July 2007 with no symptoms except slight shoulder pain on 3 occasions. They did a cath and inserted 2 stents. Started with Lipitor 10 mg. and my LDL dropped from 75 to 112. The MD wanted to double the dose, but I refused because of intermittent nocturnal nausea. MD switched me to another statin and I had immediate muscle involvement and severe nausea at night. She wanted me to try another statin drug and I refused. After a 2 month period of no statins, she put me back on Lipitor 10 mg. daily. I decided to cut the pill in half and take it twice a week, then move to every other day and gradually go to 10 mg. daily. Immediately, the nocturnal nausea started again. Last night I awoke at 2 a.m. with nausea, sweating, sore muscles around my rib cage. Still no sleep at 4:30 a.m., so I got up and tried to eat something. This has been the pattern every night since I went on Lipitor.

I don't know if I can take this any more.

CK

I ran across this site today and THANK GOD that I found it!! My mother wasn't initially given Lipitor because the first statin that her doctor prescribed made her very nauseous. He switched to 40mg of Lipitor about 2 weeks ago and she still gets extremely nauseous and have begun coughing and experiencing cold like symptoms. Her vision is EXTREMELY blurred; so much that she can't perform her job, and her previously prescribed eyeglasses are useless. She had been experiencing pain in her legs during walks that never seemed to get better. We NEVER associated it with Lipitor or the other statin until I decided to dig a little deeper.

I asked her if her doctor had told her to take CoQ10 whilst taking these statins and he's NEVER mentioned it!! As of today, my mother will no longer be taking these "medications". Reading these posts has been eye opening, to say the least. Thanks!!

For the last 2 yrs I had a horrendous cough that plagued me night & day. My Dr. didn't know what was causing the cough, couldn't give me any cough medicine to alleviate the condition. In addition to coughing, I would lose my voice. I went to an ENT specialist. She found me to have pre-polyps on my vocal chords, diagnosed me with 'vocal chord dysfunction' & told me surgery would be useless as the pre-polyps would reappear. This last June, I had a bout with bronchitis, severe enough to seek medical aid from the Emergency room Dr.'s. While there, the Dr. treating me asked about my cough. After listening to my list of aggravations, he asked if my Primary Dr. had told me that 'coughing' is a side effect of Lipitor. NO! I hadn't been told that!! --But, I QUIT taking Lipitor that day, haven't taken it since & though I still cough, somewhat, it's NOTHING compared to what I'd been suffering--for two years!!..

46 yr old male and was started on Lip. about a month ago. Overall cholesterol level was 116!! Within 3 weeks I began having soreness move across my legs and hips to begin with, Just a drained feeling. Then leg cramps in my left legs. The drained feeling intensified until I went back to my Dr. last week who immediately ordered me to stop taking any more. I had been off about 4 days when I began have severe pain, lost all color, was not able to get out of bed, could barely talk or walk and was taken to the Doctor's office this past Sat.. I was not able to set up.My wife had to basically talk for me because I was in so much pain, could not communicate, was feeling like I was leaving my body. I do not and have not taken any narcotics or alcohol, but I was given "the field sobriety test", or what I would call it, as I am retired from law enforcement and have given thousands..... But never one for lipitor!!!

I told the Dr. I do not want no drug, I want an answer. I was told to come back on Monday as the Lab. folks wouldn't be in until then. I would not have to wait.

I have used this facility for many years, but I am totally shocked. I feel I have came as close to dying as any situation I have ever been in. I have never hurt to bad. I have never have so many leg cramps. I have never woke up each morning feeling like I have never slept a minute but have been working my butt off chopping wood or digging ditches or climbing mountains all night, simply exhausted.......I will always advise people about this drug....

I have been on Lipitor for about 4 years. Now I have an arthritic right knee and the left knee has a little bit of arthritis. My arthritis started getting really bad in both legs my left leg was just as bad as my right leg. Muscle pain was tremendous and getting up and down stairs. furniture, and the car. Then the day before Memorial Day I could hardly move, I thought I was losing both my legs. I could only walk a little bit. No energy. I too had blurred vision with this drug but the doctor said that it probably was just my diabetes. I hurt from the shoulders all the way down to the ankles..It felt like every muscle group was involved. Earlier this year the doctor put my Lipitor up to 40 mg from 20 mg even through my ldl was only 93. My last ldl was 67. The doctors say your cholesterol cannot go to low but I am wondering with all the side affedts I had. I took myself off Lipitor on Memorial Day this year and I feel better. The pain is gone except for the arithritic pain but it is not as bad as what it was on Lipitor. Soo I am done with statins I will lose weight and exercise.

I started using lipitor from my doctor, it lowered my cholesterol all around but I started to have lower back pains. At first I thought it might be prostate cancer, but after having to MRI's done they found no cancer, thank god. But I went to an orthopedic surgeon to see what the problem was. He looked at the mri's and saw lower dics hitting my nerve endings. He also thought that it might be muscle problems so he gave me 3 epidurals and that helped for a while took away about 50% of my pain, but I still have the pain, It is hard for me to get comfortable when I sit or even when I am sleeping. I don't want to think that it is the lipitor that is doing it to me but after talking with others I feel it is time to talk to my doctor about it. My doctor said that lipitor is the safest one that will do very little harm to my liver. I am not a doctor so I would not know.. My cholesterol level was 246 at one time now it is 175. I am now facing possible spine fusion to help correct my disc problem. But will also ask doctor to prescribe something else.

Alan

Due to the large amount of people who suffer devastating side effects from Lipitor and other statins, I would like to encourage each and everyone of you to tell your story on home video and post that video on****** This will be one of the best ways to alert the world to the dangers of this drug.

I would encourage every patient on statins to read the recent article (Feb. 2008) by Dr. Peter Langsjoen, MD/Cardiologist: http://www.lef.org/magazine/mag2008/feb2008_Alleviating-Congestive-Heart-Failure-With-Coenzyme-Q10_01.htm

The following information from this article is pertinent to complaints of muscle pain/weakness and fatigue:

"All statin drugs block the biosynthesis of both cholesterol and CoQ10, which explains statins’ common side effects of fatigue, muscle pain and muscle weakness, and a worsening of heart failure. When CoQ10 levels are lowered by statin drug therapy, one of the first changes to occur is a weakening of heart muscle function, known as diastolic dysfunction. This has nothing to do with diastolic blood pressure, but rather represents impairment in the relaxing or filling phase of the cardiac cycle. After heart muscle contracts, it takes a great deal of cellular energy, or ATP, to re-establish the calcium gradients such that muscle fibers may relax. Thus, if diastolic dysfunction is severe, it can result in congestive heart failure. In 2004, a study published in the American Journal of Cardiology showed that diastolic dysfunction (heart muscle weakness) occurred in 70% of previously normal patients treated with 20 mg a day of Lipitor® for six months. This heart muscle dysfunction was reversible with supplemental CoQ10."

I hope this information will be of help to patients suffering adverse reactions from statins..

On lipitor for 1 1/2 years.... starting taking yoga a month ago. Had ache in knee and leg which then went to toe on other leg. Thought it was overstretching from yoga. Pain moved to hips and lower back. All very painful but worst was yet to come. Pain moved to neck and shoulders. Could not move head. Excruciating SOBBING pain. I was in so much pain for weekend. Everyone wanted me to go to emergency room but I wanted to stick it out til Monday.

PS... went on web. Saw this is lipitor side effect. never would have expected that after 1 1/2 yrs on a 10 mg dose.

Went to pain management doctor ... got Soma (muscle relaxant), an oral steroid and Percoset. Relief was almost instant.

Called my cardiologist. He says it is the Lipitor.

No more statins for me.
And back to yoga.

Over 6 years ago, the following Petition was submitted to the FDA. I would encourage every patient being treated with statins to read it and bring it to the immediate attention of their physician:

CITIZEN PETITION TO CHANGE THE LABELING FOR
ALL STATIN DRUGS (MEVACOR, LESCOL, PRAVACHOL, ZOCOR, LIPITOR, AND ADVICOR) RECOMMENDING USE OF
100-200mg PER DAY OF SUPPLEMENTAL CO-ENZYME Q10 TO REDUCE THE RISK OF STATIN-INDUCED MYOPATHIES (INCLUDING
CARDIOMYOPATHY AND CONGESTIVE HEART FAILURE). http://www.fda.gov/OHRMS/DOCKETS/dailys/02/May02/052902/02p-0244-cp00001-01-vol1.pdf
May 24, 2002
Petitioner:
Dr. Julian M. Whitaker, M.D.

This Petition is based on the clinical findings of Dr Peter H. Langsjoen, MD, who also reported it to the FDA as follows:

Statins kill people - lots of people - and they wound many, many more. All patients taking statins become depleted in Coenzyme Q10 (CoQ10), eventually - those patients who start with a relatively low CoQ10 levels (the elderly and patients with heart failure) begin to manifest signs/symptoms of CoQ10 deficiency relatively rapidly - in 6 to 12 months. Younger, healthier people who's only "illness" is the non-illness "hypercholesterolemia" can tolerate statins for several years before getting into trouble with fatigue, muscle weakness and soreness (usually with normal muscle enzyme CPK tests) and most ominously - heart failure. In my practice of 17 years in Tyler, Texas, I have seen a frightening increase in heart failure secondary to statin usage, "statin cardiomyopathy". Over the past five years, statins have become more potent, are being prescribed in higher doses, and are being used with reckless abandon in the elderly and in patients with "normal" cholesterol levels. We are in the midst of a CHF epidemic in the US with a dramatic increase over the past decade. Are we causing this epidemic through our zealous use of statins? In large part I think the answer is yes. We are now in a position to witness the unfolding of the greatest medical tragedy of all time - never before in history has the medical establishment knowingly (Merck & Co., Inc. has two 1990 patents combining CoQ10 with statins to prevent CoQ10 depletion and attendant side effects) created a life threatening nutrient deficiency in millions of otherwise healthy people, only to then sit back with arrogance and horrific irresponsibility and watch to see what happens - as I see two to three new statin cardiomyopathies per week in my practice, I cannot help but view my once great profession with a mixture of sorrow and contempt.

I am a 60 yr old woman, and have been on statins for several years, most recently 40 mg. I have been getting more and more side affects over the years that I kept attributing to age, overweight, lack of exercise. After reading so many of these postings, I stopped the statin in March. Some of the side affects i.e. the aches in my arms, hands went away fairly quickly. But my legs still ache so much and the muscles in them seem to be weak, I have a hard time standing up from a sitting position. Do any of you know if it sometimes takes this long for symptoms to go away or is it possible that they won't???

Lipitor an all Statins deplete the natural enzymes from your muscles.
Your Heart is a muscle. I haved been on Lipitor for a number of years
with many of the side effects posted here. I have had Heart Failure fo
a year now and the best doctors could not help me. My son recently
researched an found a possible solution the indicated Statins deplete
th heart muscled of COQ10 a natural enzyme in the Heart Muscle.
This depletion over time can caused Heart failure due to weak walls.
Since my doctors could offer no solution, I decided to try it for 90 days.
I am off Lipitor an taking 400mg of COQ10 per day.
I am now in day seven an have slept in my own bed with my wife for the first time in a year. I am less restless, an have ha no recurrence of Heart Failure. The drug companies know the problems but thy have
deep pockets an the best lobby to get laws passed and FDA approvals.

They have now received approval to get kids on Statins so they can
make even more money before the patient run out. Thy should be ashamed but they are not!!

Because of a “Global economy” - I suspect ingredients (even for Brand names) are coming from China or being manufactured in India with poor to non-existent quality control standards, and is the primary reason for the majority of Adverse Reactions to the Statins in general. Please take time to submit your complaint directly to the FDA, and hope they investigate and take action (see bottom of page for web sites to submit complaint).

My own recent experience with statins: After 3-weeks of being on generic Simvastatin 80mg for elevated LDL, I experienced significant fatigue, shortness of breath with tightness around my chest and a bout of Gout in my left foot. I would encourage patients/consumers to directly send their complaint to the web sites listed at the very bottom, if you are either a U.S. (FDA Form 3500) or Canadian resident. Also, if your physician is unresponsive to your negative experience with Statins (generic or Brand Name), inform him/her that you refuse to continue with this drug, and that you have sent an adverse reaction complaint to the FDA/Canadian equivalent. Provide both your doctor and pharmacy with a copy of the FDA Form 3500 if you’re a U.S. resident, so they know you're serious. Lastly, I'm back to feeling normal, after I "demanded" my physician switch me to generic Pravastatin 40mg (2 tabs a day - 80mg), manufactured by Teva Pharmaceutical - corporate HQ Israel with manufacturing facility in Pennsylvania. By the way, a 90-day supply of this quality-controlled drug is available at Walmart Pharmacy for $10. I hope this helps, especially seniors on a fixed income.

U.S.A.
http://www.fda.gov/opacom/backgrounders/problem.html

CANADA
http://www.hc-sc.gc.ca/dhp-mps/alt_formats/hpfb-dgpsa/pdf/compli-conform/gui-44_consumer_complaint-plainte_consommateur-eng.pdf
Contact Name: Drug Compliance Verification and Investigation Unit Tel: (613) 952-9906 Fax: (613) 954-0941 E-Mail: DCVIU_UVCEM@hc-sc.gc.ca

This is an update from my first posting earlier this year. I still have localized pain in my neck and shoulder area sometimes extending down my arms to my fingertips. I am 58 years old and stopped taking Lipitor 5 months ago. I am always in discomfort but the very severe pain comes in waves at least 3-4 times a month and lasts for about 1-2 days. I have noticed an improvement since stopping Lipitor but my cholesterol count is on its way up so I am trying to control that. Not an easy task but at least I am not totally debilitated as I was in January and February. I am totally off all meds and vitamins as of this writing. I am trying to cleanse myself and start over with diet and exercise. Hang tough ... this is definitely the battle of your life!!! KooKoo

Glad I took the time to read the noncommercial posts! During my thyroid check last year bloodwork showed high cholesterol. I was put on Crestor in addition to having my Synthroid dose adjusted. A few weeks later I was absolutely miserable. Couldn't get out of bed. Everything hurt. My doctor thought I was "depressed" and asked if I wanted anti-depressants. Not needing to add another pill to my daily repertoire - I declined. Six weeks later I am feeling worse and just want to lay down and cry. The doctor had no idea why I would be feeling that way and was convinced it was either depression or thyroid issue. I was getting ready to leave for a trip to Mexico that had been planned a year in advance and was non-refundable - and I didn't have the strength to even pack the stupid suitcase. The trip was a bust - I laid in a pool chair just feeling crappy. What a waste!

Funny thing - nobody stopped to consider I've had a thyroid problem for 20 years and this horrid nightmare just started after I started taking Crestor! A few weeks later I stopped the Crestor entirely and after a couple of months I felt back to normal. Now, three years later - I've been talked into taking Lipitor. In my naivety (because I explained to the doctor that Crestor made me ill) I trusted that it would be different. It's taken three weeks for me to put two and two together - but here I am again - muscle aches - can't get out of bed. Everything just hurts. My knees, arms, mostly shoulders and in between. With all that is an overall lethargic feeling. Lipitor stops today -and if the pattern continues and I feel better in a few weeks - it's no statins for me ever again. I'll just have to eat like I'm supposed to and hope for the best!

My doctor started me on Lipitor over a year ago. I started having muscle pain in my shoulders but didn't equate it to the meds until I was watching television one day and a Lipitor commercial came on. It said that some people experience muscle pain.....I thought HALLELUEH THAT'S WHAT IT IS.....I stopped talking the meds and went to see my doctor who immediately changed my meds to Zocor.....guess what? The same thing happened. Went to see her again and she switched to Crestor.....same thing happened....so I started doing my own research and was amazed at what I learned and bewildered as to why my doctor was acting like I was some whining baby.

No problem, I say to myself and stopped the meds. That was last November, in January I had my yearly physical and blood tests were ordered for me in December......guess what.....my triglycerides were still high so my doctor orders Antara. It didn't say "cor" anything so I'm thinking it's not the same stuff. No, it wasn't the same stuff it was WORSE!! Within three weeks I was crying I was in so much pain. I called her and got her nurse practitioner who says that my doctor said to stop taking the pills and the pain will go away. I call back and say, "you don't understand, I can't sleep, I can't move, I can't function the pain is so bad." After several calls back and forth, and let me tell you I NEVER call my doctor unless something is incredibly wrong and that is less than rarely. Well, my doctors partner tells the nurse practioner that they will not prescribe narcotics for me. WHAT? Who asked for narcotics? I needed relief from this pain.....I would have gone for amputation!!!

So I change docs...more blood work.....high triglycerides, I refuse to take any statins. She says she has something for me that will not cause muscle pain and hands me samples of Welchol.....this one took less than a week for increased muscle pain...again I wanted to trust, but guess what i learned when I went to the Welchol site? The first side effect listed? Muscle pain.

Called the new doctors office to let them know that I was experiencing pain again and was told to stop the Welchol (which I had already done) and take Red Yeast Rice and have bloodwork done in 3 to 6 months and come back to see her. Oh no! Not without research and guess what? A side effect of Red Yeast Rice? Muscle pain.

It has been 4 months since I stopped taking the Antara and took Welchol for a week in that 4 months. Sometimes my shoulders/neck and arms don't hurt too much. Unfortunately most times they do. Both doctors insist that the pain cannot be from the drugs because the drugs have left my body. The new doctor said I probably have myolgia just because I'm 52 and that it's just a coincidence that it happened while taken the drugs but then goes on to agree that I must be "sensitive" to statins. Both doctors treat me like I'm stupid and nuts all balled up in one. I am frustrated and in pain most of the time. I have been trying to find out how long to expect this pain and am dismayed to learn that it can be years or never go away.

Yes I have high triglycerides (so does my mother and she experiences the same kind of pain so refused to take statins) and I've been warned that not taking statins could cause pancreatitis and/or heart problems. My question to that is - "then my choice is chance the heart stuff or live an incredibly painful life?"

I'll take my chances and pray for the best because right now my quality of life stinks!!

I have been taking LIPITOR for about 1.5 years and have been feeling the cotton head but thought it was allergies. for about 8 months or so I have been feeling pain on the left side of my chest and upper back by the shoulder plates. I've told my doctor and had several tests done incl. MRI, C-scan, etc. Once I even had to go to the emergency room thinking I was having a heart attack. But the doc. said the EKG was normal and that it might be muscular. I have not read that anyone else is having the chest symptoms. This is very scary to me. Lately I feel my neck getting stiff and I am also constantly tired and keep waking up at night and have a hard time going back to sleep. I don't seem to have the arm or leg pains that most people here seem to be suffering from but am now convinced it's LIPITOR since it is the only prescription medicine I am taking. I would appreciate hearing from someone who has had the same symptoms I've described above. I stopped taking Lipitor about 4 days ago and do feel already less tired but the upper body pain is still present.

I wrote the message below on March 9th, 2008, but I think it might be useful if I repeat it.

Please educate yourself.

Are you really sure that it`s high cholesterol that is causing heart disease?

All statins have similar side effects!!
_________________________

It`s very disturbing to read all these stories. I really feel for you.

My experience comes from seeing what happened to people close to me.

They all took statins.

I started to look for information on statins, and other medications in 2004 and it continues to this day although two of my relatives are dead.

I have nothing to do with the health or pharmaceutical industry.

I saw the suffering and it made me very angry.

I am an ordinary lady in her sixties who live in Sweden.

The situation is almost the same here as in the U.S.

There is very little discussion about risks/benefits with this kind of medicatications - or others.

I think it`s a good idea to turn to the Internet and books to get other views about the cholesterol issue.

Is it really true that it`s the cholesterol that is causing heart disease?

Are you sure?

Please visit:

*******

******

*****

Also search articles etc on "Stopped our statins" and on the names of the different authors below.

Also read:

The Cholesterol Myths (Uffe Ravnskov)

The Great Cholesterol Con (Antony Colpo)

Book with the same title (Malcolm Kendrick)

Overdosed America (John Abramson)

The Truth about the Drug Companies (Marcia Agnell)

Malignant Medical Myths (Joel M. Kauffman)

There are many more.

Please look on the Internet for more information about each book.

It´s good to have some other information than the one given by doctors because most of them have been "educated" by the pharmaceutical companies themselves - and why should they talk about risks, side effects etc. They are interested in profits.

Finally - here are some side effects that I have seen:

pains in legs, hands, elbows, shoulders, knees, hips, cracking noise in ribs, muscle weakness, loss of hair, head ache, burning, tingling sensations in hands and feet, numbness, difficulties to swallow, loss of taste, ringing noise in ears, cramps, insomnia, irritation, depression, difficulty with short-term memory and then advancing into more serious problems.

These side effects - for 3 different people - all over 65 - did not come at once.

All of them had taken statins for years (Zocor)

It doesn´t matter which product -all statins have similar side effects.

Search for "Stopped our statins" on Google. It´s a very informative site and under "print articles" there are som articles that you can take along to your doctor for discussion.

I particularly like the one from Weston Price Foundation
and explains the different statin studies and side effects. .

My relatives also had some other medications which makes it even easier for doctors (and patients) to say that it`s just old age.

I am happy for those who get problems right away because then there maybe a chance for the patient and the doctor to see that there is a connection.

You really have to look out for yourself and the people around you!

Good Luck.

Found this on a web site listed at the end.
Very scary!!! COQ10 is a must when taking any statin drugs your body needs it for your
muscles. Other statin drugs may be better.

Numerous adverse side effect reports have implicated Lipitor as a possible cause for severe neuromuscular degeneration. Some people who have been using Lipitor for two years or more report symptoms similar to multiple sclerosis or ALS - Lou Gehrig's Disease - in which they are losing neuromuscular control of their bodies.

For instance, in an article entitled "Life After Lipitor" that appeared in the newspaper Tahoe World on January 27, 2004, Tahoe City (California) resident Doug Peterson began having serious neuromuscular problems after taking Lipitor for two years. He began losing muscular coordination and slurring words when he spoke. Then he lost balance, followed by loss of fine motor skills - he had difficulty writing. He went from doctor to doctor, trying to figure out what could be happening. Finally one doctor suggested that he stop taking Lipitor, and the downward health spiral stopped and his health is now slowly improving.

These adverse effects have begun appearing in peer-reviewed medical journals, and numerous people have reported similar symptoms at public adverse effect reporting websites such as medications.com. People have reported "trouble swallowing, trouble talking and enunciating words, feeling fatigued all the time, neck aches," "motor neuropathy which mimics ALS," "Blinding headaches, nausea, vertigo, disorientation, memory loss, extremely dry eyes, pain and stiffness in my neck and calf muscles, abominal pain," and "Muscle pain, weakness, spasms, buzzing in right leg. Can't hold arms or head up in vertical position for 2 minutes without extreme pain and weakness."

How could Lipitor potentially cause this kind of harm to so many different parts of the body? Lipitor is a "statin" drug which inhibits the production of cholesterol in order to lower LDL cholesterol counts. By limiting the production of cholesterol, Lipitor may be indirectly causing membrane degeneration in neural and muscle tissue.

The problem is this: cholesterol is essential in your body for many functions. It forms part of what is called the cell membrane - the outer layer of every cell in your body. It helps transport and pack the major components of the cell membrane, called "phospholipids," that are made from essential fatty acids (EFAs). Without sufficient cholesterol we would die, because our tissues are constantly being repaired and replaced with new cells.

Our body produces several thousand milligrams of cholesterol per day to carry out these essential functions, and each day the excess of cholesterol is supposed to be naturally recycled. If your body doesn't have enough new cholesterol each day, you cannot repair and replace your cell membranes and they will eventually degenerate.

The continual recycling of cholesterol happens naturally when you have sufficient ascorbate, another name for vitamin C. Excess cholesterol is naturally converted to bile acid and then excreted. But if you don't consume enough vitamin C (about 2000-3000 milligrams per day for an adult), cholesterol builds up in your bloodstream. It is here that doctors make a critical error: instead of telling you to take more vitamin C, they prescribe Lipitor.
If Lipitor and other similar statin drugs are in fact indirectly causing neural and muscular degeneration, this is a very serious matter indeed.

There are twenty million people in the U.S. on Lipitor alone, and probably millions more on other statin drugs (Zocor, Pravachol, Mevacor, Altocor, Lescol, Crestor, etc.). Are they all going to become victims of cell membrane degeneration and nervous system problems? There are few long-term studies that bear out the safety of these drugs, and side effects such as "muscle pain or weakness" are just classified as a reason for some to stop the medication rather than an indication of something very wrong with the drug.

What is most horrifying about this problem is that cholesterol balance can be achieved without drugs, simply and safely by taking 2000-3000 milligrams of vitamin C per day for an adult. Unfortunately, vitamin C was misclassified as a micronutrient in the 1930s and 1940s, rather than an essential nutrient involved in dozens of body processes. Our health authorities recommend that we take only 60 milligrams per day, barely enough to prevent scurvy.

It is my hope that people on Lipitor and other statins learn that they do not need to take these potentially harmful drugs.

For more information about the connection between vitamin C and the prevention of cardiovascular disease, see the article Natural Therapy for Cardiovascular Disease, or visit the research website of Dr. M.
******

age 72 had MI angioplasty and stent.On lipitor for 3years but recently noticed increase in muscle and joint pains and then lightheadedness and walking unsteady and tending to go slightly from side to side.Also a tendency to have nasal congestion.I am an MD and will stop the statin and assess the progress.

My mother started on Lipator about a year ago, she's been having shakes that last about 30 seconds in her legs and one arm. The shakes come and go and she can go a month without them but they seem to have gotten worst. She also has a hard time walking 4 out of days a week, she feels like her legs aren't under her. She is always tired and has restless leg,sometimes at night. She has respiratory problem that also seems to have gotten worst in the past year.
She is seeing a nuro but a cat scan, eeg and blood have all come back ok. Do you thing these are common problems with Lipator?

Hubby had angioplasty last month for 95% blockage and still has 75% blockage in two other arteries. Doctors put him on a handful of drugs (blood thinners, blood pressure meds, fish oil, aspirin) including Lipitor. Hubby has gone from healthy to being in constant pain, mostly in the legs. He had knee replacement last year and cant believe that this hurts worse! Also, his urine is darker and he has to 'go' more often. It's only been 1 month, but after reading up on the drugs, I've told him to refuse to take any more of the statins. I love him and want him around a long time, PAIN FREE. What's with these doctors?
For all of you who are suffering and wanting to get off the statins, increase your exercise to as much as you can stand, and then some! You'll not need the drugs anymore. Hubby and I are doing this as well as increasing our intake of legumes (my homemade bean soup for starters). I'd much rather he farts than cries in pain! Good luck to all and God bless you.

I have just read Maxineps very long text about the benefits of statins.

I totally disagree that the benefits far outweigh the risks.

Besides - don´t be sure that it`s hig cholesterol that is causing heart problems and therefore should be lowered.

There are other opinions by professional people all over the world, but they don´t have the financial resources that the pharmaceutical companies have and therefore it`s more difficult for them to reach out with their message.

The best thing you can do is to educate yourself on this issue and here are som books/addresses that I recommend..

The Cholesterol Myths (Uffe Ravnskov) + www.ravnskov.nu + www.thincs.org

The Great Cholesterol Con (Antony Colpo)

Book with the same title (Malcolm Kendrick)

Malignant Medical Myths (Joel M. Kauffman)

Overdosed America (John Abramson)

The side effects of statins are much more common than is suggested.

They are often thought to be problems of aging both by the patient and by the doctor.

So, please trust yourself.

It`s your body and you know best how you are feeling.

Can Statins Cause Chronic Low-Grade Myopathy?
Statins (hydroxymethyl glutaryl coenzyme A reductase
inhibitors) are highly effective drugs for reducing serum
cholesterol and low-density lipoprotein cholesterol levels.
Clinical trials have shown that they also reduce risk for
coronary heart disease events, coronary procedures, and
stroke by about one third (1). Millions of people in the
United States and worldwide are being treated with statins.
In clinical trials and in clinical practice, statins have proved
to be remarkably safe.
The one notable side effect of statin therapy is myopathy.
A small fraction of patients who are treated with
statins will develop severe myopathy (2). In the worst cases,
severe myoglobinuria, acute renal failure, and even death
can occur. The incidence of severe myopathy is low, perhaps
1 in 1000 patients (2). Predisposing factors for severe
myopathy appear to include advanced age, relatively low
body weight, female sex, certain medications, use of multiple
medications, multisystem disease, and acute illnesses
or major surgery (3). If statins were avoided or used in low
doses in these circumstances, it is likely that the incidence
of severe myopathy could be greatly reduced.
Less severe forms of myopathy undoubtedly occur. In
some patients, fatigue and muscle pain and weakness develop
with moderately high serum creatine kinase levels
but not acute renal failure. In these cases, the myopathy
resolves when statin therapy is discontinued.
Still more patients report various muscle symptoms—
fatigue, pain, and muscle weakness—but have normal creatine
kinase levels. These symptoms probably are unrelated
to statin therapy in many patients. In middle-aged and
older people, muscle, joint, and tendon symptoms are very
common. Naturally, if a patient takes a medication that is
believed to produce muscle problems, symptoms are often
attributed to the medication. On the other hand, the major
controlled clinical trials have not detected a higher prevalence
of muscle symptoms during statin therapy versus placebo
(1). This failure of detection has generally led clinical
trialists to conclude that statin-associated myopathy with
normal creatine kinase levels essentially does not exist or
that, if it does exist, it cannot be detected above the “background
noise” of muscle symptoms in the general clinicaltrial
population.
Many physicians in clinical practice nonetheless believe
that they can identify a subset of statin-treated patients
who have a unique set of statin-related muscle symptoms.
Some patients clearly relate the onset of muscle
symptoms to initiation of statin therapy. These symptoms
may abate after discontinuation of therapy, only to reappear
when statin therapy is restarted. The number of such
patients is not large, and thus it may have been impossible
to identify them in large clinical trials.
In this issue, Phillips and colleagues (4) report on a set
of studies in four patients who had muscle symptoms during
statin therapy that resolved during placebo use. Quantitatively
measured muscle weakness also resolved during
placebo use. Muscle biopsies were performed in three patients
during statin therapy and then during placebo use.
Several pathologic changes were seen on biopsy specimens
obtained during statin therapy: increased lipid content of
mitochondria, fibers that did not stain for cytochrome oxidase
activity, and ragged red fibers. The authors suggest
that these patients had statin-associated myopathy with
normal serum creatine kinase levels.
Despite the study’s small size, we cannot dismiss these
observations as random variation in muscle structure.
However, these highly suggestive results are clearly preliminary.
The number of patients was small, and all appropriate
controls were not used. Nonetheless, this study is novel
because it used quantitative measures of muscle strength
and muscle biopsy to address the question of myopathy
with normal creatine kinase levels during statin therapy.
To be confirmed, the current data would have to be
extended to many more patients in whom muscle symptoms
are closely correlated with statin use. Reproducibility
of symptoms during therapy and symptom resolution after
discontinuation of statin therapy would be necessary. A
definitive study would have to be carefully designed and
executed. It would need to be double-blinded and placebocontrolled
and include sufficient numbers of patients to
provide a valid statistical comparison. In addition, investigators
would have to carefully consider the appropriate
selection of patients. The development of a registry of candidate
patients at multiple sites could facilitate a multicenter
study.
Is a carefully controlled, sizable study of this type
worth the investment of time and effort? To date, no evidence
indicates that prolonged statin therapy leads to permanent
muscle damage or progressive myopathy in patients
with normal creatine kinase levels. Controlled
clinical trials attest to the general safety of statins, and
symptomatic side effects appear to be limited to a relatively
small proportion of treated patients. In addition, no therapy
prevents or treats statin-induced myopathy, short of
withholding the drug. On the other hand, statins are being
prescribed to millions of people, and are usually continued
throughout the patient’s lifetime. It is certain that statins
cause myopathy in some patients. For these reasons, a valid
argument can be made for a more extensive study of lowgrade
myopathy in patients treated with statins.
In the meantime, physicians should recognize the great
benefit of statin therapy in high-risk patients and their
documented safety for most patients. For high-risk persons,
the proven efficacy for preventing cardiovascular disease
outweighs the unlikely possibility of permanent muscle
damage. Phillips and colleagues’ preliminary results
certainly do not provide adequate information on the spec-
Editorial
www.annals.org 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 617
trum, scope, or prognosis of myopathy with normal creatine
kinase levels during statin therapy. For these reasons,
prescription of statins for eligible patients should continue
despite the current results. Moreover, before discontinuing
therapy, physicians should carefully evaluate any patient
receiving statins who reports muscle symptoms. In most
cases, the symptoms will be found not to be consistent
with chronic myopathy, and often they will not be related
temporally to statin treatment. High-risk patients in particular
should not be deprived of major cardiovascular risk
reduction just because they display symptoms not clearly
documented to be closely related to statin therapy.
Despite these comments, the actions of statin on muscle
metabolism and structure deserve further investigation
to clarify the confusing area of low-grade myopathy apparently
associated with statin use in a few patients.
Scott M. Grundy, MD, PhD
University of Texas Southwestern Medical Center at Dallas
Dallas, TX 75390-9052
Current Author Address: Scott M. Grundy, MD, PhD, Center for
Human Nutrition and the Departments of Clinical Nutrition and Internal
Medicine, University of Texas Southwestern Medical Center at Dallas,
5323 Harry Hines Boulevard, Y3.206, Dallas, TX 75390-9052.
Potential Financial Conflicts of Interest: Honoraria (from Merck &
Co.; Pfizer, Inc.; Bristol-Myers Squibb; and Bayer); Grants (from Merck
& Co. and Pfizer, Inc.)
Ann Intern Med. 2002;137:617-618.
References
1. Executive Summary of The Third Report of The National Cholesterol Education
Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment
of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA. 2001;
285:2486-97.
2. Staffa JA, Chang J, Green L. Cerivastatin and reports of fatal rhabdomyolysis
. N Engl J Med. 2002;346:539-40.
3. Pasternak RC, Smith SC, Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant
C. ACC/AHA/NHLBI clinical advisory on the use and safety of statins (1)
(2). J Am Coll Cardiol. 2002;40:567-72.
4. Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, et al.
Statin-associated myopathy with normal creatine kinase levels. The Scripps Mercy
Clinical Research Center. Ann Intern Med. 2002;137:581-5.
© 2002 American College of Physicians–American Society of Internal
Medicine
Editorial Statins and Low-Grade Myopathy
618 1 October 2002 Annals of Internal Medicine Volume 137 • Number 7 www.annals.org