Lupron and benadryl

My husband and I found out he had Meatastic prostate cancer 13 months ago..We went to the doctor because his lymph glands were hudge.. He has been on the Lupron injections ever since.. He had really bad hot flashes for the 1st few months but that has past, but now he is very moody and angry for no reason.. He yells and gets angry over the littlest things i think he is going crazy and he is driving me nuts, he has no desire for me and is rude and acts like he don't even like me sometimes.. it is torture to me..He has depression he doesn't enjoy anything like he use to.. whenever we go try to have fun he gets all stressed and makes the fun turn into miserable..He acts as if he has no problems..He has some big rashes on his legs and crack and I am pretty sure it is from the Lupron shot also.. he has a little aches and pains. Very tired all the time..just about a week ago we found out the Lupron shot is not working very well anymore, his psa level went up to a 15..I am thankful for the shot because i know it has saved him some time to be here.. I love him so much, but the way he is now has caused me to feel like he is a grouchy roommate on his period 24/7.. There is other things like casodex to take but i heard it does not work as well as the Lupron..Hopefully one of these days they can find something that works even better then Lupron without the side affects..The lupron Shot has helped many people live longer, but what about the quality of life he is miserable but I am sure he rather be alive and miserable.. Good luck to everyone with the Lupron shot, it is a trying time when they or you go through these changes and do not understand why you feel negative and unhappy..

I have been using Lupron for 10 days in preparation for IVF. I am so relieved to see that others have experienced similar side effects. I have had a constant nagging headache since starting the medication - not severe like a migraine, just highly annoying. I have had a few hot flashes, mostly during the night but also some during the day, which leave me feeling overall tired and "sick". The worst is the insomnia. While the hot flashes do wake me up, that is not the reason for the insomnia - it occurs every night regardless of hot flash. I can't sleep at all. Have tried benadryl but did not work at all - this is odd because it has always made me sleep any other time. Ativan does work, it's almost as if the insomnia is related to a jittery or panicked feeling. The nagging headache also seems to contribute to the insomnia. I am due to start ovarian stimulation drugs in another week, and I have read that this may alleviate the Lupron side effects. I hope so. I feel crazy and not at all like myself. I have been having horrible thoughts at night as I lie awake.